46 research outputs found
The Photodetector Array Camera and Spectrometer (PACS) on the Herschel Space Observatory
The Photodetector Array Camera and Spectrometer (PACS) is one of the three
science instruments on ESA's far infrared and submillimetre observatory. It
employs two Ge:Ga photoconductor arrays (stressed and unstressed) with 16x25
pixels, each, and two filled silicon bolometer arrays with 16x32 and 32x64
pixels, respectively, to perform integral-field spectroscopy and imaging
photometry in the 60-210\mu\ m wavelength regime. In photometry mode, it
simultaneously images two bands, 60-85\mu\ m or 85-125\mu\m and 125-210\mu\ m,
over a field of view of ~1.75'x3.5', with close to Nyquist beam sampling in
each band. In spectroscopy mode, it images a field of 47"x47", resolved into
5x5 pixels, with an instantaneous spectral coverage of ~1500km/s and a spectral
resolution of ~175km/s. We summarise the design of the instrument, describe
observing modes, calibration, and data analysis methods, and present our
current assessment of the in-orbit performance of the instrument based on the
Performance Verification tests. PACS is fully operational, and the achieved
performance is close to or better than the pre-launch predictions
Case report: an unexpected link between partial deletion of the SHANK3 gene and Heller’s dementia infantilis, a rare subtype of autism spectrum disorder
International audienceAbstractBackgroundDeletions and mutations involving the SHANK3 gene lead to a nonspecific clinical presentation with moderate to profound intellectual disability, severely delayed or absent speech, and autism spectrum disorders (ASD).Better knowledge of the clinical spectrum of SHANK3 haploinsufficiency is useful to facilitate clinical care monitoring and to guide molecular diagnosis, essential for genetic counselling.Case presentationHere, we report a detailed clinical description of a 10-year-old girl carrying a pathogenic interstitial 22q13.3 deletion encompassing only the first 17 exons of SHANK3.The clinical features displayed by the girl strongly suggested the diagnosis of dementia infantilis, described by Heller in 1908, also known as childhood disintegrative disorder.ConclusionOur present case confirms several observations according to which regression may be part of the clinical phenotype of SHANK3 haploinsufficiency. Therefore, we think it is crucial to look for mutations in the gene SHANK3 in patients diagnosed for childhood disintegrative disorder or any developmental disorder with a regressive pattern involving social and communicative skills as well as cognitive and instinctual functions, with onset around 3 years
Autoantibodies to central nervous system neuronal surface antigens: psychiatric symptoms and psychopharmacological implications
Mucous Membrane Grafting Augmented with Topical Mitomycin C Application in Contracted Socket Repair Surgeries
Site 3 : CityGate 3., Biestebroeck area
The essay presents the results of the work of group 3 of the masterclass '(Deisigning) Urban Production', organised by Metrolab Brussels, which was held in Brussels between January and February 2020. Part I