Development of a Systems Immunology Approach to Explore Factors Influencing Vaccination Response in Belgian Blue Cattle

editorial reviewe

More Accurate Insight into the Incidence of Human Rabies in Developing Countries through Validated Laboratory Techniques

International audienceNo abstract availabl

Analgésie obstétricale (étude des effets de l'administration intraveineuse autocontrôlée de sufentanil en alternative à l'analgésie péridurale)

BESANCON-BU Médecine pharmacie (250562102) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Evaluation de la TEP-FDG dans le lymphome : analyse critique des examens des 21 premiers mois au CHU de Grenoble

La TEP-FDG étant accessible à Grenoble, depuis septembre 2002, cette étude rétrospective a pour but d'évaluer nos premiers résultats dans ses différentes indications concernant le lymphome en les comparant à la littérature. Concernant le bilan d'extension et l'évaluation de la maladie résiduelle, nos résultats sont proches de la littérature. Nos résultats concernant la réponse précoce au traitement ont conduit à proposer de nouveaux critères d'interprétation afin d'améliorer la sensibilité de l'examen. L'étude réalisée sur un faible effectif, concernant la valeur pronostique de la TEP-FDG avant greffe de cellules souches, donne des résultats prometteurs. L'analyse critique de nos résultats, pendant l'apprentissage de cette technique d'imagerie fonctionnelle, permet de proposer des critères d'interprétation mieux standardisés afin d'optimiser la place de la TEP-FDG dans le suivi thérapeutique des patients atteints de lymphome.GRENOBLE1-BU Médecine pharm. (385162101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Inauguration du monument eleve par l'Astrolabe a La Perouse a Vanikoro, 14th March, 1828 [picture].

Attributed to de Sainson by Rex Nan Kivell, apparently because of the existence of his lithograph of the same subject; revised attribution based on research by Dr Roger Collins.; Rex Nan Kivell Collection NK11641.; Exhibited: "Inauguration du Monument Eleve par L'Astrolabe", Museum of Sydney, Dec 2002 - April 2003; Exhibited: "Treasures Gallery", National Library of Australia, 10 July 2013 - 13 October 2013 and 22 March 2014 – 28 July 2014. AuCNL; (ANL)T2709; Exhibited: Discerning Eye, RNK Collection, Canberra 1992; Sydney 1992; Melbourne 1992-1993

Sendai Virus and a Unified Model of Mononegavirus RNA Synthesis

International audienceVesicular stomatitis virus (VSV), the founding member of the mononegavirus order (Mononegavirales), was found to be a negative strand RNA virus in the 1960s, and since then the number of such viruses has continually increased with no end in sight. Sendai virus (SeV) was noted soon afterwards due to an outbreak of newborn pneumonitis in Japan whose putative agent was passed in mice, and nowadays this mouse virus is mainly the bane of animal houses and immunologists. However, SeV was important in the study of this class of viruses because, like flu, it grows to high titers in embryonated chicken eggs, facilitating the biochemical characterization of its infection and that of its nucleocapsid, which is very close to that of measles virus (MeV). This review and opinion piece follow SeV as more is known about how various mononegaviruses express their genetic information and carry out their RNA synthesis, and proposes a unified model based on what all MNV have in common

ESRD-associated immune phenotype depends on dialysis modality and iron status: clinical implications

Abstract Background End-stage renal disease (ESRD) causes premature ageing of the immune system. However, it is not known whether hemodialysis (HD) and peritoneal dialysis (PD) similarly affect the T cell system. Methods The aim of our study was to analyse whether dialysis modality may mitigate ESRD-induced immune senescence. We explored a large population of patients (675 ESRD patients) and both confirmed and refined the results in a second cohort (84 patients). Results HD patients exhibited higher inflammatory monocytes counts (44/mm3 (1–520) vs 36/mm3 (1–161); p = 0.005). Patients on HD also had higher frequency of CD8 T cells (24% (7–61) vs 22% (8–42); p = 0.003) and reduced CD4/CD8 ratio. Such results were confirmed in the second cohort. Moreover, both CD4 + CD57 + CD28- (3.25% (0–38.2) vs 1.05% (0–28.5); p = 0.068) and CD8 + CD57 + CD28- (38.5% (3.6–76.8) vs 26.1 (2.1–46.9); p = 0.039) T cells frequencies were increased in HD patients. Telomere length did not differ according to dialysis modality, but was inversely related to ferritin levels (r = − 0.33; p = 0.003). There was a trend towards higher telomerase activity in PD patients (11 ± 13 vs 6 ± 11; p = 0.053). Thymic function was not different in PD and HD patients. Patients on PD before transplantation had a higher risk of acute rejection after kidney transplantation (HR, 1.61; 95%CI, 1.02 to 2.56; p = 0.041). Conclusions More pronounced inflammation with hemodialysis may induce premature aging of the immune system. This observation correlates with a lower risk of acute kidney rejection in patients previously on HD. Clinical consequences in patients maintained on dialysis should be determined. Trial registration Trial registration: NCT02843867, registered July 8, 2016