1,101 research outputs found
Higher Derivative Corrections to R-charged Black Holes: Boundary Counterterms and the Mass-Charge Relation
We carry out the holographic renormalization of Einstein-Maxwell theory with
curvature-squared corrections. In particular, we demonstrate how to construct
the generalized Gibbons-Hawking surface term needed to ensure a perturbatively
well-defined variational principle. This treatment ensures the absence of ghost
degrees of freedom at the linearized perturbative order in the
higher-derivative corrections. We use the holographically renormalized action
to study the thermodynamics of R-charged black holes with higher derivatives
and to investigate their mass to charge ratio in the extremal limit. In five
dimensions, there seems to be a connection between the sign of the higher
derivative couplings required to satisfy the weak gravity conjecture and that
violating the shear viscosity to entropy bound. This is in turn related to
possible constraints on the central charges of the dual CFT, in particular to
the sign of c-a.Comment: 30 pages. v2: references added, some equations simplifie
Correlation between mesio-distal teeth diameters and arch width
Objective: To verify the existence of a correlation between the mesio-distal size of teeth and the arch width by analyzing the data separately for maxillary and mandibular arch in patients with ideal occlusion. Material and Methods: 58 patients with ideal occlusion were studied, for a total of 276 files analyzed. Dental casts were then scanned using a professional scanner (Epson Perfection v 330) and images were obtained in TIFF format at 600 dpi. All single teeth measurements were carried out for all teeth of both arches using the VAM software (Vectra, Canfield Scientific, Fairfield, NJ, USA). The repeatability and reproducibility of the measurement method were evaluated using the Gauge R&R method. In case a correlation between tooth size and arch size is found to be significant, a linear regression analysis can be applied through the following statistical relationship: y=a+b*x, where y is the result (inter-molar distance “AvgB66” or inter-canine distance “Cusp 33”), and x the specific tooth. The a and b respectively represent the intercept (point of intersection between the line and the y axis) and the slope of the line that describes the regression ratio. Results: The statistical analysis highlights a significant correlation (p<1%) between the results of the mesio-distal measurements of each tooth and the two variables considered to define the size of each arch (“AvgB66” and “Cusp 33”). Based on these results, a numerical relationship "y=a+b*x" has been extrapolated. Thus, it is possible to calculate the estimated inter-molar or inter canine distance necessary to have the teeth aligned. Conclusion: The inter-canine and inter-molar distances can be estimated starting from measuring the mesio-distal diameter of a single tooth
Viscosity Bound and Causality in Superfluid Plasma
It was argued by Brigante et.al that the lower bound on the ratio of the
shear viscosity to the entropy density in strongly coupled plasma is translated
into microcausality violation in the dual gravitational description. Since
transport properties of the system characterize its infrared dynamics, while
the causality of the theory is determined by its ultraviolet behavior, the
viscosity bound/microcausality link should not be applicable to theories that
undergo low temperature phase transitions. We present an explicit model of
AdS/CFT correspondence that confirms this fact.Comment: 27 pages, 5 figures. References added, typos fixe
On the Temperature Dependence of the Shear Viscosity and Holography
We examine the structure of the shear viscosity to entropy density ratio
eta/s in holographic theories of gravity coupled to a scalar field, in the
presence of higher derivative corrections. Thanks to a non-trivial scalar field
profile, eta/s in this setup generically runs as a function of temperature. In
particular, its temperature behavior is dictated by the shape of the scalar
potential and of the scalar couplings to the higher derivative terms. We
consider a number of dilatonic setups, but focus mostly on phenomenological
models that are QCD-like. We determine the geometric conditions needed to
identify local and global minima for eta/s as a function of temperature, which
translate to restrictions on the signs and ranges of the higher derivative
couplings. Finally, such restrictions lead to an holographic argument for the
existence of a global minimum for eta/s in these models, at or above the
deconfinement transition.Comment: references adde
Drug Screening in Human Cells by NMR Spectroscopy Allows the Early Assessment of Drug Potency
Structure-based drug development is often hampered by the lack of in vivo activity of promising compounds screened in vitro, due to low membrane permeability or poor intracellular binding selectivity. Herein, we show that ligand screening can be performed in living human cells by “intracellular protein-observed” NMR spectroscopy, without requiring enzymatic activity measurements or other cellular assays. Quantitative binding information is obtained by fast, inexpensive 1H NMR experiments, providing intracellular dose- and time-dependent ligand binding curves, from which kinetic and thermodynamic parameters linked to cell permeability and binding affinity and selectivity are obtained. The approach was applied to carbonic anhydrase and, in principle, can be extended to any NMR-observable intracellular target. The results obtained are directly related to the potency of candidate drugs, that is, the required dose. The application of this approach at an early stage of the drug design pipeline could greatly increase the low success rate of modern drug development
Generating Temperature Flow for eta/s with Higher Derivatives: From Lifshitz to AdS
We consider charged dilatonic black branes in AdS_5 and examine the effects
of perturbative higher derivative corrections on the ratio of shear viscosity
to entropy density eta/s of the dual plasma. The structure of eta/s is
controlled by the relative hierarchy between the two scales in the plasma, the
temperature and the chemical potential. In this model the background
near-horizon geometry interpolates between a Lifshitz-like brane at low
temperature, and an AdS brane at high temperatures -- with AdS asymptotics in
both cases. As a result, in this construction the viscosity to entropy ratio
flows as a function of temperature, from a value in the IR which is sensitive
to the dynamical exponent z, to the simple result expected for an AdS brane in
the UV. Coupling the scalar directly to the higher derivative terms generates
additional temperature dependence, and leads to a particularly interesting
structure for eta/s in the IR.Comment: Plots and references added. Journal version of the pape
Facing up to bias in healthcare: The influence of familiarity appearance on hiring decisions
Associations between facial appearance and hiring decisions are well-documented within job literature as a source of decision misjudgment with economic and human costs. Notwithstanding, this aspect is yet to be investigated in healthcare. We collected 90 pictures of new-graduates nurses faces to be judged on different facial appearance-based traits by an independent sample. Six months after graduation, the same new-graduates were interviewed about their job situation. Binomial logistic regression was conducted to examine whether facial appearance ratings would predict the probability to be hired as nurse. Results showed that applicants with a face conveying a feeling of familiarity were more likely to be hired. Considering that people might be inclined to these biases during societal crises and the exceptional need to quickly recruit health professionals during COVID-19 pandemic, our study recommends special attention to prevent the influence of facial appearance-based evaluations not reflecting real skills to limit potentially adverse consequences
The effect of higher derivative correction on and conductivities in STU model
In this paper we study the ratio of shear viscosity to entropy, electrical
and thermal conductivities for the R-charged black hole in STU model. We
generalize previous works to the case of a black hole with three different
charges. Actually we use diffusion constant to obtain ratio of shear viscosity
to entropy. By applying the thermodynamical stability we recover previous
results. Also we investigate the effect of higher derivative corrections.Comment: revised versio
De Sitter Holography with a Finite Number of States
We investigate the possibility that, in a combined theory of quantum
mechanics and gravity, de Sitter space is described by finitely many states.
The notion of observer complementarity, which states that each observer has
complete but complementary information, implies that, for a single observer,
the complete Hilbert space describes one side of the horizon. Observer
complementarity is implemented by identifying antipodal states with outgoing
states. The de Sitter group acts on S-matrix elements. Despite the fact that
the de Sitter group has no nontrivial finite-dimensional unitary
representations, we show that it is possible to construct an S-matrix that is
finite-dimensional, unitary, and de Sitter-invariant. We present a class of
examples that realize this idea holographically in terms of spinor fields on
the boundary sphere. The finite dimensionality is due to Fermi statistics and
an `exclusion principle' that truncates the orthonormal basis in which the
spinor fields can be expanded.Comment: 23 pages, 1 eps figure, LaTe
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