Broadband Fourier-transform silicon nitride spectrometer with wide-area multiaperture input

4 pags., 5 figs.Integrated microspectrometers implemented in silicon photonic chips have gathered a great interest for diverse applications such as biological analysis, environmental monitoring, and remote sensing. These applications often demand high spectral resolution, broad operational bandwidth, and large optical throughput. Spatial heterodyne Fourier-transform (SHFT) spectrometers have been proposed to overcome the limited optical throughput of dispersive and speckle-based on-chip spectrometers. However, state-of-the-art SHFT spectrometers in near-infrared achieve large optical throughput only within a narrow operational bandwidth. Here we demonstrate for the first time, to the best of our knowledge, a broadband silicon nitride SHFT spectrometer with the largest light collecting multiaperture input (320 × 410 µm) ever implemented in an SHFT on-chip spectrometer. The device was fabricated using 248 nm deep-ultraviolet lithography, exhibiting over 13 dB of optical throughput improvement compared to a single-aperture device. The measured resolution varies between 29 and 49 pm within the 1260-1600 nm wavelength range.Spanish Ministry of Science and Innovation (MICINN) (RED2018-102768-T, RTI2018-097957-B-C33, TEC2015-71127-C2-1-R (FPI Scholarship BES-2016-077798)); Community of Madrid-FEDER funds (S2018/NMT-4326); Horizon 2020 Research and Innovation Program (Marie Sklodowska-Curie 734331); H2020 European Research Council (ERC POPSTAR 647342); European Commission (H2020- ICT-26127-2017 COSMICC 688516); French Industry Ministry (Nano2022 project under IPCEI program); Agence Nationale de la Recherche (ANR-MIRSPEC-17-CE09-004

Impact of Low-Level-Viremia on HIV-1 Drug-Resistance Evolution among Antiretroviral Treated-Patients

to determine the emergence and evolution of DRAM during LLV in HIV-1-infected patients while receiving antiretroviral therapy (ART).Retrospective analysis of patients presenting a LLV episode defined as pVL between 40 and 500 c/mL on at least 3 occasions during a 6-month period or longer while on the same ART. Resistance genotypic testing was performed at the onset and at the end of LLV period. Emerging DRAM was defined during LLV if never detected on baseline genotype or before.48 patients including 4 naive and 44 pretreated (median 9 years) presented a LLV episode with a median duration of 11 months. Current ART included 2NRTI (94%), ritonavir-boosted PI (94%), NNRTI (23%), and/or raltegravir (19%). Median pVL during LLV was 134 c/mL. Successful resistance testing at both onset and end of the LLV episode were obtained for 37 patients (77%), among who 11 (30%) acquired at least 1 DRAM during the LLV period: for NRTI in 6, for NNRTI in 1, for PI in 4, and for raltegravir in 2. During the LLV period, number of drugs with genotypic resistance increased from a median of 4.5 to 6 drugs. Duration and pVL level of LLV episode, duration of previous ART, current and nadir CD4 count, number of baseline DRAM and GSS were not identified as predictive factors of resistance acquisition during LLV, probably due to limited number of patients.Persistent LLV episodes below 500 c/ml while receiving ART is associated with emerging DRAM for all drug classes and a decreasing in further therapeutic options, suggesting to earlier consider resistance monitoring and ART optimization in this setting

Prognostic impact of vitamin B6 metabolism in lung cancer

Patients with non-small cell lung cancer (NSCLC) are routinely treated with cytotoxic agents such as cisplatin. Through a genome-wide siRNA-based screen, we identified vitamin B6 metabolism as a central regulator of cisplatin responses in vitro and in vivo. By aggravating a bioenergetic catastrophe that involves the depletion of intracellular glutathione, vitamin B6 exacerbates cisplatin-mediated DNA damage, thus sensitizing a large panel of cancer cell lines to apoptosis. Moreover, vitamin B6 sensitizes cancer cells to apoptosis induction by distinct types of physical and chemical stress, including multiple chemotherapeutics. This effect requires pyridoxal kinase (PDXK), the enzyme that generates the bioactive form of vitamin B6. In line with a general role of vitamin B6 in stress responses, low PDXK expression levels were found to be associated with poor disease outcome in two independent cohorts of patients with NSCLC. These results indicate that PDXK expression levels constitute a biomarker for risk stratification among patients with NSCLC.publishedVersio

Pourquoi réaliser des analyses de sol?

Le sol est un capital à préserver impérativement. Depuis plusieurs décennies, de nombreux outils ont été mis en place pour aider l’agriculteur dans son mode de gestion du sol (aide au prélèvement, analyse de terre, amélioration des conseils de fertilisation, dispositifs pour limiter l’érosion, adaptation des travaux de sol…). L’agriculture de précision tend à se développer et pourtant, en Province de Luxembourg, 59 % des agriculteurs n’analysent toujours pas leurs terres

Gestion et entretien des gagnages : les analyses de sols

De nombreux gagnages herbeux ou cultures à gibier sont installés sur le territoire wallon. Cependant, il n’est pas rare de constater que leur entretien laisse parfois à désirer, et notamment en matière de fertilisation et de maintien de la fertilité du sol. Pourtant, ce dernier est un capital à préserver impérativement. Il est à la base de toutes les productions végétale