Adoption, profitability and future of leucaena feeding systems in Australia

Leucaena (Leucaena leucocephala ssp. glabrata) is a highly palatable and productive forage used mainly by beef producers on extensive properties in northern Australia. When sown into native or sown grass pastures, leucaena provides significant production, economic, environmental and social benefits. Adoption of leucaena was slow initially due to a range of technical, agronomic and landscape factors. These have now been largely overcome through extensive research, development, producer experience and other advances, resulting in around 130,000 ha of cultivated leucaena being utilized across northern Australia. A range of aspects will need to be addressed if the adoption of leucaena is to be accelerated into the future. These include environmental concerns, especially potential weediness, and a range of technological needs, including soil nutritional requirements, grazing and toxicity management, opportunities for companion fodder systems and conservation options. Advances in technology and the ongoing need for a high-quality, profitable and sustainable perennial forage will ensure the continued adoption of leucaena across northern Australia for the foreseeable future. © 2019, Centro Internacional de Agricultura Tropical (CIAT)

Adoption, profitability and future of leucaena feeding systems in Australia

Leucaena (Leucaena leucocephala ssp. glabrata) is a highly palatable and productive forage used mainly by beef producers on extensive properties in northern Australia. When sown into native or sown grass pastures, leucaena provides significant production, economic, environmental and social benefits. Adoption of leucaena was slow initially due to a range of technical, agronomic and landscape factors. These have now been largely overcome through extensive research, development, producer experience and other advances, resulting in around 130,000 ha of cultivated leucaena being utilized across northern Australia. A range of aspects will need to be addressed if the adoption of leucaena is to be accelerated into the future. These include environmental concerns, especially potential weediness, and a range of technological needs, including soil nutritional requirements, grazing and toxicity management, opportunities for companion fodder systems and conservation options. Advances in technology and the ongoing need for a high-quality, profitable and sustainable perennial forage will ensure the continued adoption of leucaena across northern Australia for the foreseeable future. © 2019, Centro Internacional de Agricultura Tropical (CIAT)

Comparing Biorefinery Processes at the Early Design Stage Using Large Block Analysis

ABSTRACT: The transformation of pulp and paper mills through the integration of biorefineries is increasingly considered essential to the future of many existing sites. However, evaluating the risk and return of different biorefinery process alternatives at the early design stage is challenging. There are many strategies and technologies that must be considered, each of which is typically accompanied by its unique risks, including high levels of uncertainty in capital and operating cost estimates often obtained from technology providers. The novel methodology presented in this study, called Large Block Analysis (LBA), comprises a systematic approach for addressing these important challenges at the early design stage. LBA is used to obtain relative cost estimates for six process/product combinations incorporating different Technology Readiness Levels (TRLs), for adding value to a hemicellulose stream extracted from hardwood chips. In this case study, it was found that the fixed capital costs obtained using the LBA method differed from the original costs by between 121 and −19%, and operating cost estimates differed by between 117 and −17% from the original. The results show that the most economically-viable options for the hemicellulose stream having reasonable technology risk included the production of (1) animal feed additives, (2) xylitol using a variant of the classical chemical process, and (3) furfural

Investigation into durable polymers with enhanced toughness and elasticity for application in flexible Li-Ion batteries

Next-generation wearable devices compel the development of lithium-ion batteries (LIBs) that can afford mechanical flexibility while remaining safe and stable energy sources. In conventional battery designs the electrode coatings are susceptible to fracture and disintegration when exposed to cyclic flexure. This results in capacity loss, resistance increases, and severely limits their cycle life. Polyurethane (PU) has been investigated as a battery binder but without research into the variety of chemistries available, and how they affect performance. This research investigates three different PU chemistries, each composed of a different polyol backbone–polyester, polyether and polycaprolactone. These are compared with PVDF, the most commonly used rigid binder in industry. The combination of electrochemical and mechanical characterization identified the importance of PU binder chemistry, particularly when the binder’s interaction with the electrolyte was considered. Both the polyester and polycaprolactone PU chemistries swelled significantly when placed in an electrolyte, compromising their conductive networks and mechanical advantages. In contrast, polyether PU was found to be a suitable binder for flexible batteries as it has strong adhesion and retains its properties even after swelling in the electrolyte. These findings present a promising polymer choice to facilitate the development of advanced and durable electrodes for flexible energy storage systems

Patent: Fusion Proteins for Treating Metabolic Disorders

The invention relates to the identification of fusion proteins comprising polypeptide and protein variants of fibroblast growth factor 21 (FGF21) with improved pharmaceutical properties. Also disclosed are methods for treating FGF21 associated disorders, including metabolic conditions

Limited Impact of the Protein Corona on the Cellular Uptake of PEGylated Zein Micelles by Melanoma Cancer Cells

The formation of a protein layer corona on the nanoparticle surface upon entry into a biological environment was shown to strongly influence the interactions with cells, especially affecting the uptake of nanomedicines. In this work, we present the impact of the protein corona on the uptake of PEGylated zein micelles by cancer cells, macrophages, and dendritic cells. Zein was successfully conjugated with poly(ethylene glycol) (PEG) of varying chain lengths (5K and 10K) and assembled into micelles. Our results demonstrate that PEGylation conferred stealth effects to the zein micelles. The presence of human plasma did not impact the uptake levels of the micelles by melanoma cancer cells, regardless of the PEG chain length used. In contrast, it decreased the uptake by macrophages and dendritic cells. These results therefore make PEGylated zein micelles promising as potential drug delivery systems for cancer therapy

Bentho-Pelagic Divergence of Cichlid Feeding Architecture Was Prodigious and Consistent during Multiple Adaptive Radiations within African Rift-Lakes

<b>Background</b> How particular changes in functional morphology can repeatedly promote ecological diversification is an active area of evolutionary investigation. The African rift-lake cichlids offer a calibrated time series of the most dramatic adaptive radiations of vertebrate trophic morphology yet described, and the replicate nature of these events provides a unique opportunity to test whether common changes in functional morphology have repeatedly facilitated their ecological success.<p></p> <b>Methodology/Principal Findings</b> Specimens from 87 genera of cichlid fishes endemic to Lakes Tanganyka, Malawi and Victoria were dissected in order to examine the functional morphology of cichlid feeding. We quantified shape using geometric morphometrics and compared patterns of morphological diversity using a series of analytical tests. The primary axes of divergence were conserved among all three radiations, and the most prevalent changes involved the size of the preorbital region of the skull. Even the fishes from the youngest of these lakes (Victoria), which exhibit the lowest amount of skull shape disparity, have undergone extensive preorbital evolution relative to other craniofacial traits. Such changes have large effects on feeding biomechanics, and can promote expansion into a wide array of niches along a bentho-pelagic ecomorphological axis.<p></p> <b>Conclusions/Significance</b> Here we show that specific changes in trophic anatomy have evolved repeatedly in the African rift lakes, and our results suggest that simple morphological alterations that have large ecological consequences are likely to constitute critical components of adaptive radiations in functional morphology. Such shifts may precede more complex shape changes as lineages diversify into unoccupied niches. The data presented here, combined with observations of other fish lineages, suggest that the preorbital region represents an evolutionary module that can respond quickly to natural selection when fishes colonize new lakes. Characterizing the changes in cichlid trophic morphology that have contributed to their extraordinary adaptive radiations has broad evolutionary implications, and such studies are necessary for directing future investigations into the proximate mechanisms that have shaped these spectacular phenomena

Unexpected selective gas adsorption on a 'non-porous' metal organic framework

A metal organic framework Cu(tpt)BF 4· 3 4 H 2O was synthesized as a potential carbon capture material, with the aim being to exploit the Lewis base interaction of the incorporated ligand functionalities with acidic gas. The material displays high thermal stability but an exceptionally low surface area; however, this contrasts starkly with its ability to capture carbon dioxide, demonstrating significant activated diffusion within the framework. The full characterization of the material shows a robust structure, where the CO 2 sorption is 120% greater than current industrial methods using liquid amine solutions; the thermal energy required for sorbent regeneration is reduced by 65%, indicating the true industrial potential of the synthesized material

The 6-minute walk test and other endpoints in Duchenne muscular dystrophy: longitudinal natural history observations over 48 weeks from a multicenter study.

IntroductionDuchenne muscular dystrophy (DMD) subjects ≥5 years with nonsense mutations were followed for 48 weeks in a multicenter, randomized, double-blind, placebo-controlled trial of ataluren. Placebo arm data (N = 57) provided insight into the natural history of the 6-minute walk test (6MWT) and other endpoints.MethodsEvaluations performed every 6 weeks included the 6-minute walk distance (6MWD), timed function tests (TFTs), and quantitative strength using hand-held myometry.ResultsBaseline age (≥7 years), 6MWD, and selected TFT performance are strong predictors of decline in ambulation (Δ6MWD) and time to 10% worsening in 6MWD. A baseline 6MWD of <350 meters was associated with greater functional decline, and loss of ambulation was only seen in those with baseline 6MWD <325 meters. Only 1 of 42 (2.3%) subjects able to stand from supine lost ambulation.ConclusionFindings confirm the clinical meaningfulness of the 6MWD as the most accepted primary clinical endpoint in ambulatory DMD trials