La pesquisa en Castilla y Aragón: un caso curioso del Libre deis Feyts de Jaume I

In this autobiographical Libre dels Feyts, James I the Conqueror, King of Aragon, describes a juridical procedure which he instituted in 1267 against a gang of counterfeiters operating out of the town of Tarazona. This procedure, which the King calls an "inquisició", corresponds exactly to the "pesquisa" of the neighboring kingdom of Castile, although the Aragonese legal tradition was theoretically hostile to the "pesquisa" as a legal instrument. Here the various steps of James'trial of the counterfeiters are compared to the regulations governing the use of "pesquisa" in contemporary Alfonsine legislation.[fr] Dans son autobiographie le Libre dels Feyts, Jacques I le Conquérant, roi d'Aragon, décrit un procédé juridique qu'il a utilisé en 1267 contre une bande de faux-monnayeurs de la ville de Tarazona. Ce procédé, appelle "inquisició" par le roi, correspond pas à pas à la "pesquisa" du royaume voisin de Castille, bien que l'inquisition était théoriquement exclue de l'établissement juridique aragonais. Ici on compare les étapes du procès raconté par Jacques I avec les règlements sur la "pesquisa" dans la législation contemporaine d'Alphonse X le Sage

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

A Bibliography of the Legislative Works of Alfonso X el Sabio (1986) with update (1981-1990)

Annotated bibliography of the legislative works of Alfonso X, King of Castile and Leon 1252-1284, with update through 1990

Comentario de comentarios: Los naufragios de Alvar Núñez Cabeza de Vaca

Critique of the annotations of the Pupo-Walker edition (1992) of the Naufragios, including and edition of the "Relación breve" with facsimiles of the document

Disparatario del suroeste 1 (in English)

Occasional lexical observations on unusual words or phrases in the documents of the Hispanic Southwest