ViDA: a VlasovDArwin solver for plasma physics at electron scales

We present a Vlasov–DArwin numerical code (ViDA) specifically designed to address plasma physics problems, where small-scale high accuracy is requested even during the nonlinear regime to guarantee a clean description of the plasma dynamics at fine spatial scales. The algorithm provides a low-noise description of proton and electron kinetic dynamics, by splitting in time the multi-advection Vlasov equation in phase space. Maxwell equations for the electric and magnetic fields are reorganized according to the Darwin approximation to remove light waves. Several numerical tests show that ViDA successfully reproduces the propagation of linear and nonlinear waves and captures the physics of magnetic reconnection. We also discuss preliminary tests of the parallelization algorithm efficiency, performed at CINECA on the Marconi-KNL cluster. ViDA will allow the running of Eulerian simulations of a non-relativistic fully kinetic collisionless plasma and it is expected to provide relevant insights into important problems of plasma astrophysics such as, for instance, the development of the turbulent cascade at electron scales and the structure and dynamics of electron-scale magnetic reconnection, such as the electron diffusion region

Colorectal Cancer Stage at Diagnosis Before vs During the COVID-19 Pandemic in Italy

IMPORTANCE Delays in screening programs and the reluctance of patients to seek medical attention because of the outbreak of SARS-CoV-2 could be associated with the risk of more advanced colorectal cancers at diagnosis. OBJECTIVE To evaluate whether the SARS-CoV-2 pandemic was associated with more advanced oncologic stage and change in clinical presentation for patients with colorectal cancer. DESIGN, SETTING, AND PARTICIPANTS This retrospective, multicenter cohort study included all 17 938 adult patients who underwent surgery for colorectal cancer from March 1, 2020, to December 31, 2021 (pandemic period), and from January 1, 2018, to February 29, 2020 (prepandemic period), in 81 participating centers in Italy, including tertiary centers and community hospitals. Follow-up was 30 days from surgery. EXPOSURES Any type of surgical procedure for colorectal cancer, including explorative surgery, palliative procedures, and atypical or segmental resections. MAIN OUTCOMES AND MEASURES The primary outcome was advanced stage of colorectal cancer at diagnosis. Secondary outcomes were distant metastasis, T4 stage, aggressive biology (defined as cancer with at least 1 of the following characteristics: signet ring cells, mucinous tumor, budding, lymphovascular invasion, perineural invasion, and lymphangitis), stenotic lesion, emergency surgery, and palliative surgery. The independent association between the pandemic period and the outcomes was assessed using multivariate random-effects logistic regression, with hospital as the cluster variable. RESULTS A total of 17 938 patients (10 007 men [55.8%]; mean [SD] age, 70.6 [12.2] years) underwent surgery for colorectal cancer: 7796 (43.5%) during the pandemic period and 10 142 (56.5%) during the prepandemic period. Logistic regression indicated that the pandemic period was significantly associated with an increased rate of advanced-stage colorectal cancer (odds ratio [OR], 1.07; 95%CI, 1.01-1.13; P = .03), aggressive biology (OR, 1.32; 95%CI, 1.15-1.53; P < .001), and stenotic lesions (OR, 1.15; 95%CI, 1.01-1.31; P = .03). CONCLUSIONS AND RELEVANCE This cohort study suggests a significant association between the SARS-CoV-2 pandemic and the risk of a more advanced oncologic stage at diagnosis among patients undergoing surgery for colorectal cancer and might indicate a potential reduction of survival for these patients

MMS Observations of Protons and Heavy Ions Acceleration at Plasma Jet Fronts

International audiencePlasma jet fronts in the Earth's magnetotail are kinetic-scale boundaries separating hot fast plasma jets, generally attributed to reconnection outflows, from colder ambient plasma. Jet fronts are typically associated with a sharp increase of the vertical component of the magnetic field Bz, an increase of the plasma temperature and a drop of plasma density. Spacecraft observations and numerical simulations indicate that jet fronts are sites of major ion acceleration. The exact acceleration mechanisms as well as the dependence of such mechanisms on ion composition are not fully understood, yet. Recent high-resolution measurements of ion distribution functions in the magnetotail allow for the first time to study the acceleration mechanisms in detail. Here, we show several examples of jet fronts and discuss ion acceleration therein. We show fronts that propagate in the mid-tail magnetotail both as isolated laminar boundaries and as multiple boundaries embedded in strong magnetic fluctuations and turbulence. We also show fronts in the near-Earth jet braking region, where they interact with the dipolar magnetic field and are significantly decelerated/diverted. Finally, we study the acceleration of different ion species (H , He , O ) at different types of fronts and we discuss possible different acceleration mechanisms and how they depend on the ion species