The Ursinus Weekly, October 12, 1967

Pulitzer winner speaks on economic insight • Students elect USGA committee to co-ordinate students, faculty • Tragedy shocks students; Death of senior mourned • Class officers elected; Frosh choose leaders • Chi Alpha sets program plans • UC freshman tops Curtain Club\u27s cast • Editorial • A hall is not a home • Radio-free Canada • A modest proposal, a satire: For preventing dissent and resentment on the Ursinus campus, and for increasing unity of thought • Poker flats open amid dissent; Latest in do-it-yourself dorms • Rebirth of learning anticipated: Fine arts added to curriculum • WRUC goes AM-FM, plans live sportscasts • Impact of EXPO • College Scholars Program to end cult of courses • Bears outplayed, outclassed in Hopkins debacle • Bears battered by Blue Jays following 6-6 tie with Mules • Booters sweep two in convincing style, soccer year bright • Intramural corner • Moser\u27s two goals assure hockey win • Jayvees open year with double shutout • Greek gleaningshttps://digitalcommons.ursinus.edu/weekly/1178/thumbnail.jp

The Ursinus Weekly, May 2, 1966

Demolition in store for Supply • New officers take over • Campus Chest proceeds break all records • Band concert • Free seating, love it or starve! • Job opportunities • Dr. Caroline Doane to teach at Miles College • Editorial: The student and the Draft • Dean\u27s List student ignores blindness: Penny Wright succeeds in college but history soothes her to sleep • Faculty members immortalized by Beta Sig\u27s poll • Three English Comp professors use New Key to stimulate frosh • Letters to the editor • Netmen win one of four • Trackmen lose to PMC, mile relay decisive • Lacrosse team drops 2nd in ten years • Women\u27s tennis team 1-3 on season • Greek gleanings • UC\u27s voice in Harrisburghttps://digitalcommons.ursinus.edu/weekly/1224/thumbnail.jp

The Ursinus Weekly, December 13, 1965

Dean explains Student Activities Committee • Clamer girls bring to campus the Sound of Christmas • Mary Griffiths reigns over Prom • Festivities fill U.C. holiday week • Tradition highlights 28th Messiah performance • H-ford prof to speak on Vietnam • Second student concert attended by UC students • Summer jobs abound in D.C. • Greeks hold kids\u27 Xmas parties • Editorial: Congratulations to the Agency; APO decorates campus; Nocturnal serenade • How does a Mr. become a Dr. ? Reporter traces progress of Professor to demonstrate long, arduous route • Is CMP integrated? No! Now wait! Just maybe • Page editor analyzes dining hall situation; Blames both sides for affair, but sees real hope ahead • Grapplers pin Delaware Valley team • Intramural corner • B-ballers set mark: Rout drew 109-78 as Troster scores his 1,000th point • Football banquet • Letter winners • Greek gleanings • Pledging fills campus with wacky sights as frats and sororities test new members: Girls model PJs, learn birthdays, decorate rooms; Men wear shirts, drink raw eggs, visit Syracusehttps://digitalcommons.ursinus.edu/weekly/1213/thumbnail.jp

The Ursinus Weekly, November 10, 1966

Delta Pi\u27s queen reigns at annual Homecoming • U.C. students aid delinquents • Founder\u27s Day emphasizes church relationship: Three honorary degrees conferred • U.C. poetry reading • CBS reporter to speak at Forum • Behind the scenes innovations • Faculty team at War College • Local businesses educate employees • Editorial: Salvation; The moon is down • On cinnamon and seething • Letters to the editor: If you can\u27t win fairly, cheat? • Book review • New faculty building announced; Program gains momentum • Freeland\u27s ghost laments disrespect for traditions • Lyndon Johnson in Collegeville? Recent visit proves possibility: Receives giant welcome from Polish • Dickinson tops Bears in fourth quarter, 13-10 • Booters blank Delaware; Lose to Swarthmore, Haverford • Alfred whips UC, 60-8 • Cross country team wins seven of first eight • Swarthmore ruins Homecoming, 21-6 • Hockey team undefeated; Trips W.C. 1-0 • Ursinus fares well at All College • Intramural report • Ursinus hockey team beats Wilson 3-0 • First and third teams combine to down Temple 5-0 • Greek gleanings • Chapel schedulehttps://digitalcommons.ursinus.edu/weekly/1193/thumbnail.jp

The Ursinus Weekly, January 10, 1966

Senate urges reading period before exams • The Freeland story • The Ursinus plan: To advance the quality of education at UC • UC receives $25,000 grant • Alumni fund hits new peak in contributions • Lantern contest proclaims winners • Roster changes • Examination schedule • We\u27ll not forget: A promise to Freeland; Old building to be razed to provide Library site • A senior\u27s view of Freeland: Can Library replace Freeland\u27s primacy? • An alumnus\u27 view of Freeland: Alumnus recalls Freeland as source of campus activities • Search into Ursinus history substantiates second oldest graduate\u27s assertion: Yes, Freeland was indeed everything • Delaware flattens UC: Rivell, Struthers only winners • Bears crush S\u27more; Fall to PMC • Intramural corner • Greek gleaningshttps://digitalcommons.ursinus.edu/weekly/1214/thumbnail.jp

The Ursinus Weekly, December 2, 1968

Arts Forum held; 4 foreign students featured on panel • Board OKs student members on committees; Student Senate endorses SFARC resolution • Camino real scheduled for December 6th • Mandrake concert is hit; Rock group shows profit • Editorial: Our play; The larger issue • Letters to the editor • Tradition vs. change • Herberg sees anomic moral crisis; Fun morality termed other directed • SFARC minutes • Opinion: Speaker fails to prove dilemma • Freeland Hall: Don\u27t let it be forgot • Senior looks at Freeland: Can Library replace Freeland\u27s primacy? • Search into history substantiates claim of second oldest graduate that Freeland was everything • Instructor asks what do students really want? • Now is the time to unite • WRUC increases wattage to allow greater service • USGA discusses Black Alliance • Students to decide on two government proposals • Pratt art show opens at Ursinus • PNE Folk Fest held; U.C. talent featured • U.C. sponsors Career Days • Howard honored for achievements • Gurzynski\u27s men win title; Albert leads UC to championship • Soccer team edges LaSalle after losing to Haverford • Flowers win intramural crown with 6-0 victory over Sig Rho • Whatley lauds squad; predicts progress • Bears destroy Haverford; Shuman wins Maxwell Award • All Stars will visit Glassboro • Greek gleaningshttps://digitalcommons.ursinus.edu/weekly/1167/thumbnail.jp

The Ursinus Weekly, December 19, 1968

Messiah presented by Ursinus choir; Performances draw SRO audiences • Frat system & houses favored by students; 12% thumbs down! • 878 enrolled in U.C. Evening School • YM-YWCA supports SFARC investigation • Editorial: Activities chaos rolls on • Drama in real life • Student long-term planning committee report • Letters to the editor • Flu strikes East; U.C. still healthy • A memory with pillars • A Christmas story • Murmurs from within • Exchange • Faculty portrait: Mr. Sharp; Hangup on social problems overshadows intellectual quest • UC pranks: They\u27re all in good fun; Was Freeland ghost really Dr. Helfferich? • Many of greatest pranks took place in Chapel • Doctors Yost and Parsons recall Ursinus shenanigans of yesteryear; Boycotts, pigs, moths make hits • Protheatre makes hit debut in New Theatre production • Opinion: Open letter to Byron Jackson • Greek gleanings • Winning doesn\u27t count but being clean-shaven does • Snellbelles open against Moravian • Outweighed, but still fighting • Bears to face area teams, will see many super sophs • Women\u27s wrestling wound-up • Quiet revolution topic of discussion • Dr. Lewis announces $1000 trust fund • Blacks\u27 non-recognition: one topic for USGAhttps://digitalcommons.ursinus.edu/weekly/1168/thumbnail.jp

The Lantern Vol. 34, No. 2, May 1968

• The Man Without a System • A Medal for Malcolm • On Hearing That Tonya Will Be Married • The Black Sea • Odyssey \u2767 • Second Poem to Chris • Singularity • Period 5-A Began • Long and Aching Ride • Souvenirs • My Eschatological Epitaph • Discotheque • Some Borrowed Words • False Breakthrough • Shore Morning • The Beholder • Thursday Childless • A Most Prominent Role • It Ran Out • Shades of the Living • The Dark Night of the Mind II • One Step Beyond the Doors • A Note of Thanks to My Parents and Teachers • To a Dead Hippie • A Scrap • Love • Haiku No. 30 • Rachel • There Is No Present • Winter Woods • One Hundred Per Cent Genuine • Heaven • Silence Is Like God • I Soaked Up Silence • Opened Letter From Whistler Homer, Insaned Assailant • Sol Clutch Rides Tonight • I Have Seen Destruction • Upon That Night • That\u27s Weird • Alone • Kathy\u27s Tune • On Walking Home • The Wheel • Some Excuse, at Least • Freedom to Flap • Awareness • Okay, You Guys • You Say You Dream • Bacci Miahttps://digitalcommons.ursinus.edu/lantern/1093/thumbnail.jp

Mapping the decision pathways of acute infection management in secondary care among UK medical physicians: a qualitative study.

BACKGROUND: The inappropriate use of antimicrobials drives antimicrobial resistance. We conducted a study to map physician decision-making processes for acute infection management in secondary care to identify potential targets for quality improvement interventions. METHODS: Physicians newly qualified to consultant level participated in semi-structured interviews. Interviews were audio recorded and transcribed verbatim for analysis using NVIVO11.0 software. Grounded theory methodology was applied. Analytical categories were created using constant comparison approach to the data and participants were recruited to the study until thematic saturation was reached. RESULTS: Twenty physicians were interviewed. The decision pathway for the management of acute infections follows a Bayesian-like step-wise approach, with information processed and systematically added to prior assumptions to guide management. The main emerging themes identified as determinants of the decision-making of individual physicians were (1) perceptions of providing 'optimal' care for the patient with infection by providing rapid and often intravenous therapy; (2) perceptions that stopping/de-escalating therapy was a senior doctor decision with junior trainees not expected to contribute; and (3) expectation of interactions with local guidelines and microbiology service advice. Feedback on review of junior doctor prescribing decisions was often lacking, causing frustration and confusion on appropriate practice within this cohort. CONCLUSION: Interventions to improve infection management must incorporate mechanisms to promote distribution of responsibility for decisions made. The disparity between expectations of prescribers to start but not review/stop therapy must be urgently addressed with mechanisms to improve communication and feedback to junior prescribers to facilitate their continued development as prudent antimicrobial prescribers

Small Molecule, Non-Peptide p75NTR Ligands Inhibit Aβ-Induced Neurodegeneration and Synaptic Impairment

The p75 neurotrophin receptor (p75NTR) is expressed by neurons particularly vulnerable in Alzheimer's disease (AD). We tested the hypothesis that non-peptide, small molecule p75NTR ligands found to promote survival signaling might prevent Aβ-induced degeneration and synaptic dysfunction. These ligands inhibited Aβ-induced neuritic dystrophy, death of cultured neurons and Aβ-induced death of pyramidal neurons in hippocampal slice cultures. Moreover, ligands inhibited Aβ-induced activation of molecules involved in AD pathology including calpain/cdk5, GSK3β and c-Jun, and tau phosphorylation, and prevented Aβ-induced inactivation of AKT and CREB. Finally, a p75NTR ligand blocked Aβ-induced hippocampal LTP impairment. These studies support an extensive intersection between p75NTR signaling and Aβ pathogenic mechanisms, and introduce a class of specific small molecule ligands with the unique ability to block multiple fundamental AD-related signaling pathways, reverse synaptic impairment and inhibit Aβ-induced neuronal dystrophy and death