Mechanisms of Zika virus infection and neuropathogenesis

A spotlight has been focused on the mosquito-borne Zika virus (ZIKV) because of its epidemic outbreak in Brazil and Latin America, as well as the severe neurological manifestations of microcephaly and Guillain–Barré syndrome associated with infection. In this review, we discuss the recent literature on ZIKV-host interactions, including new mechanistic insight concerning the basis of ZIKV-induced neuropathogenesis

Pedagogic Metaphors and the Nature of Accounting Signification

This paper concerns three metaphors for financial statements associated with accounting education: lenses, photographs, and the board game, Scrabble. These metaphors not only describe financial statements but also affect our interpretations of them and our behavior towards them. The lens metaphor has many implications that accounting cannot live up to; however, that does not mean that it is an inappropriate metaphor to express our aspirations for accounting and to inspire our students. The Scrabble metaphor is a somewhat pejorative metaphor that we may cynically apply to accounting, but it may also be an effective means of criticizing mindless manipulation of financial statement elements. The photographic metaphor, occupying a middle ground, might be the most intriguing of the three. At an elementary level, it captures some simple truths about accounting, or at least some simple statements we would like to be true. But as the complexities of the metaphor are explored, they reveal a variety of intriguing ontological issues that concern financial statements

Money n\u27 Motion - Born to be Wild

There are intriguing parallels between motoring and personal investing: the romance, the thrilling movement, and the freedom; the banality, the enervating repetition, and the entrapment; the subconsciously seductive appeal of crashes that ends it all. Consequently, there are intriguing parallels between the automobile and accounting, without which the activities of motoring and personal investing, respectively, would be severely attenuated, if they were possible at all. And there are intriguing parallels between popular media and accounting education, which are responsible for the enculturation processes that perpetuate the beliefs that in motoring and personal investing, by means of automobiles and accounting, we can be independent, we can be free, we can take control of our lives, and we can rise above the barriers of our social classes. The historian George W. Pierson\u27s mobility thesis explains these parallels. Motoring is not merely a fruitful metaphor for personal investing, automobiles for accounting, and popular media for accounting education. Motoring and personal investing are just two among many manifestations of the mobility which is characteristically American. Physically and financially, Americans need to be in motion

Effective surface motion on a reactive cylinder of particles that perform intermittent bulk diffusion

In many biological and small scale technological applications particles may transiently bind to a cylindrical surface. In between two binding events the particles diffuse in the bulk, thus producing an effective translation on the cylinder surface. We here derive the effective motion on the surface, allowing for additional diffusion on the cylinder surface itself. We find explicit solutions for the number of adsorbed particles at one given instant, the effective surface displacement, as well as the surface propagator. In particular sub- and superdiffusive regimes are found, as well as an effective stalling of diffusion visible as a plateau in the mean squared displacement. We also investigate the corresponding first passage and first return problems.Comment: 26 pages, 5 figure

Interferon lambda protects the female reproductive tract against Zika virus infection

Zika virus infections can cause devastating congenital birth defects but the underlying interactions with the host immune system are not well understood. Here, the authors examine the immune basis of vaginal protection and susceptibility to Zika viral infection, and identify a hormonal dependent role for interferon-lambda-mediated protection against disease

Solute and Bacterial Transport through Partially-Saturated Intact Soil Blocks

Steady-state transport of water, chloride and bacteria was measured through intact blocks of Maury and Cecil soils, under partially saturated conditions. Major objectives were to determine if transport occurs uniformly or via preferential flow paths, and if soil physical properties could be used to predict breakthrough. The blocks were instrumented with TDR probes and mounted on a vacuum chamber containing 100 cells that collected eflluent. After each experiment the blocks were sampled for soil physical properties. The fluxes showed no spatial autocorrelation and the eflluent variance was not statistically different between soils. Less than 3% of the influent bacteria appeared in the effluent. Maximum bacterial breakthrough occurred after 0.25 water-filled pore volumes had been leached, and was greater for Cecil soil than for Maury soil. The chloride breakthrough curves were fitted to the convection dispersion equation. The best predictor of dispersivity was volumetric water content (R2 = 0.28, P \u3c 0.01), with dispersivity increasing with decreasing water content. Lower water contents lead to more tortuous flow paths and thus, a broadening of the velocity distribution. Soil structural controls on solute dispersion under partially saturated conditions are likely to be indirect, and related to differences in water content at given flux produced by differences in pore-size distribution

Bulk-mediated surface diffusion on a cylinder: propagators and crossovers

We consider the effective surface motion of a particle that freely diffuses in the bulk and intermittently binds to that surface. From an exact approach we derive various regimes of the effective surface motion characterized by physical rates for binding/unbinding and the bulk diffusivity. We obtain a transient regime of superdiffusion and, in particular, a saturation regime characteristic for the cylindrical geometry. This saturation, however, in a finite system is not terminal but eventually turns over to normal surface diffusion. The first passage behavior of particles to the cylinder surface is derived. Consequences for actual systems are discussed.Comment: 4 pages REVTeX4, 2 figure

Characterization of Pfiesteria Ichthyocidal Activity

Letter to the Editor regarding article: Drgon, T., et al. 2005. Characterization of ichthyocidal activity of Pfiesteria piscicida: Dependence on the dinospore cell density. Appl. Environ. Microbiol. 71:519–52

Satellite tracking highlights difficulties in the design of effective protected areas for Critically Endangered leatherback turtles Dermochelys coriacea during the inter-nesting period

The globally distributed leatherback turtle Der- mochelys coriacea is subject to fisheries bycatch throughout its range. Protection from fisheries within pelagic foraging habitats is difficult to achieve but may be more tractable when populations are concentrated near neritic breeding and nesting grounds. We used satellite telemetry to de- scribe patterns of habitat utilization during the inter- nesting period for seven leatherback turtles nesting at Mayumba National Park in Gabon on the equatorial West African coast. The National Park includes critical nesting grounds and a marine protected area to 15 km offshore. Turtles dispersed widely from the nesting beach spending a mean of 62 - SD 26% of tracking time outside the confines of the National Park. This propensity to disperse is likely to increase the chance of deleterious interactions with fisheries in the region. Patterns of habitat utilization indicate the need for wider spatial scale planning on the West African continental shelf to enhance protection of leatherback turtles when they are seasonally occupying these habitats in great numbers for breeding and nesting

Impact of Ceftolozane-Tazobactam vs. Best Alternative Therapy on Clinical Outcomes in Patients with Multidrug-Resistant and Extensively Drug-Resistant Pseudomonas aeruginosa Lower Respiratory Tract Infections

INTRODUCTION: Infections caused by multidrug-resistant (MDR), extensively drug-resistant (XDR), and difficult-to-treat (DTR) Pseudomonas aeruginosa are increasingly challenging to combat. Ceftolozane-tazobactam (C/T) is a novel β-lactam-β-lactamase inhibitor combination now commonly used to treat MDR and XDR P. aeruginosa. Lower respiratory tract infections (LRTIs) remain the most common source of infection caused by MDR/XDR P. aeruginosa. Comparative effectiveness studies to date have been limited by the type of comparator agents (i.e., aminoglycosides and polymyxins) and the inclusion of multiple infection sources (i.e., urinary tract, abdominal, skin and soft tissue, etc.). METHODS: We performed a multicenter, retrospective analysis of adults with LRTI caused by MDR or XDR P. aeruginosa admitted from January 2014 to December 2019. We aimed to compare clinical outcomes between patients who received C/T (n = 118) versus best alternative therapy (n = 88). The primary outcome was clinical failure, defined as 30-day mortality and/or an adverse drug reaction on antibiotic therapy. RESULTS: Two hundred and six patients met inclusion criteria. The C/T group had a significantly higher proportion of XDR P. aeruginosa and ventilator-associated bacterial pneumonia (VABP). After multivariable logistic regression, C/T treatment was independently associated with a 73.3% reduction in clinical failure compared to those who received best alternative therapy (P \u3c 0.001). The number needed to harm with best alternative therapy was 3. CONCLUSION: Our results suggest that C/T is a safe and effective therapeutic regimen for patients with MDR and XDR P. aeruginosa LRTI