4,110 research outputs found
PaperQA: Retrieval-Augmented Generative Agent for Scientific Research
Large Language Models (LLMs) generalize well across language tasks, but
suffer from hallucinations and uninterpretability, making it difficult to
assess their accuracy without ground-truth. Retrieval-Augmented Generation
(RAG) models have been proposed to reduce hallucinations and provide provenance
for how an answer was generated. Applying such models to the scientific
literature may enable large-scale, systematic processing of scientific
knowledge. We present PaperQA, a RAG agent for answering questions over the
scientific literature. PaperQA is an agent that performs information retrieval
across full-text scientific articles, assesses the relevance of sources and
passages, and uses RAG to provide answers. Viewing this agent as a question
answering model, we find it exceeds performance of existing LLMs and LLM agents
on current science QA benchmarks. To push the field closer to how humans
perform research on scientific literature, we also introduce LitQA, a more
complex benchmark that requires retrieval and synthesis of information from
full-text scientific papers across the literature. Finally, we demonstrate
PaperQA's matches expert human researchers on LitQA
An exploration of concepts of community through a case study of UK university web production
The paper explores the inter-relation and differences between the concepts of occupational community, community of practice, online community and social network. It uses as a case study illustration the domain of UK university web site production and specifically a listserv for those involved in it. Different latent occupational communities are explored, and the potential for the listserv to help realize these as an active sense of community is considered. The listserv is not (for most participants) a tight knit community of practice, indeed it fails many criteria for an online community. It is perhaps best conceived as a loose knit network of practice, valued for information, implicit support and for the maintenance of weak ties. Through the analysis the case for using strict definitions of the theoretical concepts is made
Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS)
Background: Amyotrophic lateral sclerosis (ALS), a common late-onset neurodegenerative disease, is associated with fronto-temporal dementia (FTD) in 3-10% of patients. A mutation in CHMP2B was recently identified in a Danish pedigree with autosomal dominant FTD. Subsequently, two unrelated patients with familial ALS, one of whom also showed features of FTD, were shown to carry missense mutations in CHMP2B. The initial aim of this study was to determine whether mutations in CHMP2B contribute more broadly to ALS pathogenesis.
Methodology/Principal Findings: Sequencing of CHMP2B in 433 ALS cases from the North of England identified 4 cases carrying 3 missense mutations, including one novel mutation, p. Thr104Asn, none of which were present in 500 neurologically normal controls. Analysis of clinical and neuropathological data of these 4 cases showed a phenotype consistent with the lower motor neuron predominant (progressive muscular atrophy (PMA)) variant of ALS. Only one had a recognised family history of ALS and none had clinically apparent dementia. Microarray analysis of motor neurons from CHMP2B cases, compared to controls, showed a distinct gene expression signature with significant differential expression predicting disassembly of cell structure; increased calcium concentration in the ER lumen; decrease in the availability of ATP; down-regulation of the classical and p38 MAPK signalling pathways, reduction in autophagy initiation and a global repression of translation. Transfection of mutant CHMP2B into HEK-293 and COS-7 cells resulted in the formation of large cytoplasmic vacuoles, aberrant lysosomal localisation demonstrated by CD63 staining and impairment of autophagy indicated by increased levels of LC3-II protein. These changes were absent in control cells transfected with wild-type CHMP2B.
Conclusions/Significance: We conclude that in a population drawn from North of England pathogenic CHMP2B mutations are found in approximately 1% of cases of ALS and 10% of those with lower motor neuron predominant ALS. We provide a body of evidence indicating the likely pathogenicity of the reported gene alterations. However, absolute confirmation of pathogenicity requires further evidence, including documentation of familial transmission in ALS pedigrees which might be most fruitfully explored in cases with a LMN predominant phenotype
What are communities of practice? A comparative review of four seminal works
This paper is a comparative review of four seminal works on communities of practice. It is argued that the ambiguities of the terms community and practice are a source of the concept's reusability allowing it to be reappropriated for different purposes, academic and practical. However, it is potentially confusing that the works differ so markedly in their conceptualizations of community, learning, power and change, diversity and informality. The three earlier works are underpinned by a common epistemological view, but Lave and Wenger's 1991 short monograph is often read as primarily about the socialization of newcomers into knowledge by a form of apprenticeship, while the focus in Brown and Duguid's article of the same year is, in contrast, on improvising new knowledge in an interstitial group that forms in resistance to management. Wenger's 1998 book treats communities of practice as the informal relations and understandings that develop in mutual engagement on an appropriated joint enterprise, but his focus is the impact on individual identity. The applicability of the concept to the heavily individualized and tightly managed work of the twenty-first century is questionable. The most recent work by Wenger – this time with McDermott and Snyder as coauthors – marks a distinct shift towards a managerialist stance. The proposition that managers should foster informal horizontal groups across organizational boundaries is in fact a fundamental redefinition of the concept. However it does identify a plausible, if limited, knowledge management (KM) tool. This paper discusses different interpretations of the idea of 'co-ordinating' communities of practice as a management ideology of empowerment
Propagation of cosmic-ray nucleons in the Galaxy
We describe a method for the numerical computation of the propagation of
primary and secondary nucleons, primary electrons, and secondary positrons and
electrons. Fragmentation and energy losses are computed using realistic
distributions for the interstellar gas and radiation fields, and diffusive
reacceleration is also incorporated. The models are adjusted to agree with the
observed cosmic-ray B/C and 10Be/9Be ratios. Models with diffusion and
convection do not account well for the observed energy dependence of B/C, while
models with reacceleration reproduce this easily. The height of the halo
propagation region is determined, using recent 10Be/9Be measurements, as >4 kpc
for diffusion/convection models and 4-12 kpc for reacceleration models. For
convection models we set an upper limit on the velocity gradient of dV/dz < 7
km/s/kpc. The radial distribution of cosmic-ray sources required is broader
than current estimates of the SNR distribution for all halo sizes. Full details
of the numerical method used to solve the cosmic-ray propagation equation are
given.Comment: 15 pages including 23 ps-figures and 3 tables, latex2e, uses
emulateapj.sty (ver. of 11 May 1998, enclosed), apjfonts.sty, timesfonts.sty.
To be published in ApJ 1998, v.509 (December 10 issue). More details can be
found at http://www.gamma.mpe-garching.mpg.de/~aws/aws.html Some references
are correcte
Scalability of Non-intrusive Load Monitoring for Shipboard Applications
The non-intrusive load monitor has been demonstrated as an effective tool for evaluating and monitoring shipboard electro-mechanical systems through analysis of electrical power data. A key advantage of the non-intrusive approach is the ability to reduce sensor count by monitoring collections of loads. This paper reviews trade-offs that affect the likely performance of the NILM in a real world environment.Massachusetts Institute of Technology. Sea Grant College Program; Grainger Foundation; National Science Foundation (U.S.); United States. National Aeronautics and Space Administration; United States. Coast Guard; United States. Office of Naval Research. Electric Ship Research and Development Consortium; NAVSEA; University of North Carolin
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