Changes in Community Rhetoric and Imagery of Rural Land Uses at the Urban Fringe: Douglas County from Strong to Slow Growth

Growth and change at the rural-urban fringe of any urbanizing area creates heated debate. The way in which people talk about change is oftentimes through stories, using rhetoric and imagery to paint a picture of what is or ought to be. In this case study of Douglas County, Kansas, imagery and rhetoric of changing rural land uses is analyzed from planning documents, newspaper articles, and interviews with planners and commission members during two distinct time periods, one of high population growth (1995 to 1999), and one of slowing population growth (2005 to 2009). The researcher found that despite differing economic situations, much of the rhetoric between the two time periods was similar. The biggest difference, however, was in the different resource conflicts between the two time periods - water and soils, respectively. Despite the economic recession during the latter time period, much long-term planning resulted. What planner and city officials can learn from this research is that despite economic hardship, periods of slow population growth may be excellent windows for long-range planning to occur. These periods could be used to assess community resources, gather citizen input, and plan accordingly for what the community wants to be like in the future. Stories, in this way, may not just serve as rhetorical fodder. In this way, stories may influence land-use decisions made on a policy level, and consequently, the physical characteristics of a community itself

Assessing the scholar CanMEDS role in residents using critical appraisal techniques

Background: In this brief report, we describe two ways in which we assessed the Scholar CanMEDS role using a method to measure residents’ ability to complete a critical appraisal.  These were incorporated into a modified OSCE format where two stations consisted of 1) critically appraising an article and 2) critiquing an abstract.Method: Residents were invited to participate in the CanMEDS In-Training Exam (CITE) through the Office of Postgraduate Medical Education. Mean scores for the two Scholar stations were calculated using the number of correct responses out of 10. The global score represented the examiner’s overall impression of the resident’s knowledge and effort.  Correlations between scores are also presented between the two Scholar stations and a paired sample t-test comparing the global mean scores of the two stations was also performed.Results: Sixty-three of the 64 residents registered to complete the CanMEDS In-Training Exam including the two Scholar stations.  There were no significant differences between the global scores of the Scholar stations showing that the overall knowledge and effort of the residents was similar across both stations (3.8 vs. 3.5, p = 0.13).  The correlation between the total mean scores of both stations (inter-station reliability) was also non-significant (r = 0.05, p = 0.67).  No significant differences between senior residents and junior residents were detected or between internal medicine residents and non-internal medicine residents.Conclusion: Further testing of these stations is needed and other novel ways of assessing the Scholar role competencies should also be investigated

Specific microbial communities associate with the rhizosphere of Welwitschia mirabilis, a living fossil

Welwitschia mirabilis is an ancient and rare plant distributed along the western coast of Namibia and Angola. Several aspects of Welwitschia biology and ecology have been investigated, but very little is known about the microbial communities associated with this plant. This study reports on the bacterial and fungal communities inhabiting the rhizosphere ofW. mirabilis and the surrounding bulk soil. Rhizosphere communities were dominated by sequences of Alphaproteobacteria and Euromycetes, while Actinobacteria, Alphaproteobacteria, and fungi of the class Dothideomycetes jointly dominated bulk soil communities. Although microbial communities within the rhizosphere and soil samples were highly variable, very few “species” (OTUs defined at a 97% identity cut-off) were shared between these two environments. There was a small ‘core’ rhizosphere bacterial community (formed by Nitratireductor, Steroidobacter, Pseudonocardia and three Phylobacteriaceae) that together with Rhizophagus, an arbuscular mycorrhizal fungus, and other putative plant growth-promoting microbes may interact synergistically to promote Welwitschia growth.S1 Fig. Welwitschia plants dotted across an arid landscape (left). The exposed radial root system of a Welwitschia plant (right).S2 Fig. Rarefaction curves. a) bacteria, b) fungi. Sample nomenclature is as in S1 Table.S3 Fig. Bar graph showing the phylum-level distribution of (a) bacterial and (b) fungal OTUs (97% cutoff). The taxonomic affiliation was performed using the Ribosomal Database Project Classifier (bacteria) and the UNITE database (fungi).S4 Fig. Venn diagram showing the number of shared phylotypes observed between the rhizosphere samples. a) bacteria, b) fungi. Sample nomenclature is as in S1 Table.S1 Table. Bacterial diversity. Sample nomenclature indicates the sample type (S = bulk soil; R = rhizosphere), replicate (S = 1 to 5, R = 1 to 3) and pseudoreplicate (a, b).S2 Table. Fungal diversity. Sample nomenclature is as in S1 Table.The National Research Foundation, South Africahttp://www.plosone.orgam2016Genetic

Impact of Genotyping of Mycobacterium tuberculosis on Public Health Practice in Massachusetts

Massachusetts was one of seven sentinel surveillance sites in the National Tuberculosis Genotyping and Surveillance Network. From 1996 through 2000, isolates from new patients with tuberculosis (TB) underwent genotyping. We describe the impact that genotyping had on public health practice in Massachusetts and some limitations of the technique. Through genotyping, we explored the dynamics of TB outbreaks, investigated laboratory cross-contamination, and identified Mycobacterium tuberculosis strains, transmission sites, and accurate epidemiologic links. Genotyping should be used with epidemiologic follow-up to identify how resources can best be allocated to investigate genotypic findings

The role of tenascin-C in tissue injury and tumorigenesis

The extracellular matrix molecule tenascin-C is highly expressed during embryonic development, tissue repair and in pathological situations such as chronic inflammation and cancer. Tenascin-C interacts with several other extracellular matrix molecules and cell-surface receptors, thus affecting tissue architecture, tissue resilience and cell responses. Tenascin-C modulates cell migration, proliferation and cellular signaling through induction of pro-inflammatory cytokines and oncogenic signaling molecules amongst other mechanisms. Given the causal role of inflammation in cancer progression, common mechanisms might be controlled by tenascin-C during both events. Drugs targeting the expression or function of tenascin-C or the tenascin-C protein itself are currently being developed and some drugs have already reached advanced clinical trials. This generates hope that increased knowledge about tenascin-C will further improve management of diseases with high tenascin-C expression such as chronic inflammation, heart failure, artheriosclerosis and cancer

Physics case for an LHCb Upgrade II - Opportunities in flavour physics, and beyond, in the HL-LHC era

The LHCb Upgrade II will fully exploit the flavour-physics opportunities of the HL-LHC, and study additional physics topics that take advantage of the forward acceptance of the LHCb spectrometer. The LHCb Upgrade I will begin operation in 2020. Consolidation will occur, and modest enhancements of the Upgrade I detector will be installed, in Long Shutdown 3 of the LHC (2025) and these are discussed here. The main Upgrade II detector will be installed in long shutdown 4 of the LHC (2030) and will build on the strengths of the current LHCb experiment and the Upgrade I. It will operate at a luminosity up to 2×1034 cm−2s−1, ten times that of the Upgrade I detector. New detector components will improve the intrinsic performance of the experiment in certain key areas. An Expression Of Interest proposing Upgrade II was submitted in February 2017. The physics case for the Upgrade II is presented here in more depth. CP-violating phases will be measured with precisions unattainable at any other envisaged facility. The experiment will probe b → sl+l−and b → dl+l− transitions in both muon and electron decays in modes not accessible at Upgrade I. Minimal flavour violation will be tested with a precision measurement of the ratio of B(B0 → μ+μ−)/B(Bs → μ+μ−). Probing charm CP violation at the 10−5 level may result in its long sought discovery. Major advances in hadron spectroscopy will be possible, which will be powerful probes of low energy QCD. Upgrade II potentially will have the highest sensitivity of all the LHC experiments on the Higgs to charm-quark couplings. Generically, the new physics mass scale probed, for fixed couplings, will almost double compared with the pre-HL-LHC era; this extended reach for flavour physics is similar to that which would be achieved by the HE-LHC proposal for the energy frontier