75 research outputs found

    New red giants in NGC 6791 and NGC 6819 using Kepler superstamps

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    Context. Stars that are members of stellar clusters are assumed to be formed at the same time and place from material with the same initial chemical composition. These additional constraints on the ensemble of cluster stars make these stars suitable as benchmarks. Aims. We aimed 1) to identify previously unknown red giants in the open clusters NGC 6791 and NGC 6819, 2) to extract their asteroseismic parameters, and 3) to determine their cluster membership. Methods. We followed a dedicated method based on difference imaging to extract the light curves of potential red giants in NGC 6791 and NGC 6819 from Kepler superstamp data. We extracted the asteroseismic parameters of the stars that showed solar-like oscillations. We performed an asteroseismic membership study to identify which of these stars are likely to be cluster members. Results. We found 149 red giant stars within the Kepler superstamps, 93 of which are likely cluster members. We were able to find 29 red giants that are not primary targets of Kepler, and therefore, their light curves had not been released previously. Five of these previously unknown red giants have a cluster membership probability greater than 95%.Comment: 10 pages, 7 figures, to be published in Astronomy & Astrophysic

    Nanostructural Diversity of Synapses in the Mammalian Spinal Cord

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    This work for funded by the Biotechnology and Biological Sciences Research Council (BBSRC; BB/M021793/1), RS MacDonald Charitable Trust, Motor Neurone Disease (MND) Association UK (Miles/Apr18/863-791), the Engineering and Physical Sciences Research Council (EPSRC; EP/P030017/1), Welcome Trust (202932/Z/16/Z), European Research Council (ERC; 695568) and the Simons Initiative for the Developing Brain.Functionally distinct synapses exhibit diverse and complex organisation at molecular and nanoscale levels. Synaptic diversity may be dependent on developmental stage, anatomical locus and the neural circuit within which synapses reside. Furthermore, astrocytes, which align with pre and post-synaptic structures to form “tripartite synapses”, can modulate neural circuits and impact on synaptic organisation. In this study, we aimed to determine which factors impact the diversity of excitatory synapses throughout the lumbar spinal cord. We used PSD95-eGFP mice, to visualise excitatory postsynaptic densities (PSDs) using high-resolution and super-resolution microscopy. We reveal a detailed and quantitative map of the features of excitatory synapses in the lumbar spinal cord, detailing synaptic diversity that is dependent on developmental stage, anatomical region and whether associated with VGLUT1 or VGLUT2 terminals. We report that PSDs are nanostructurally distinct between spinal laminae and across age groups. PSDs receiving VGLUT1 inputs also show enhanced nanostructural complexity compared with those receiving VGLUT2 inputs, suggesting pathway-specific diversity. Finally, we show that PSDs exhibit greater nanostructural complexity when part of tripartite synapses, and we provide evidence that astrocytic activation enhances PSD95 expression. Taken together, these results provide novel insights into the regulation and diversification of synapses across functionally distinct spinal regions and advance our general understanding of the ‘rules’ governing synaptic nanostructural organisation.Publisher PDFPeer reviewe

    Neuron-glial Interactions

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    Although lagging behind classical computational neuroscience, theoretical and computational approaches are beginning to emerge to characterize different aspects of neuron-glial interactions. This chapter aims to provide essential knowledge on neuron-glial interactions in the mammalian brain, leveraging on computational studies that focus on structure (anatomy) and function (physiology) of such interactions in the healthy brain. Although our understanding of the need of neuron-glial interactions in the brain is still at its infancy, being mostly based on predictions that await for experimental validation, simple general modeling arguments borrowed from control theory are introduced to support the importance of including such interactions in traditional neuron-based modeling paradigms.Junior Leader Fellowship Program by “la Caixa” Banking Foundation (LCF/BQ/LI18/11630006

    Neuron-Glial Interactions

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    Although lagging behind classical computational neuroscience, theoretical and computational approaches are beginning to emerge to characterize different aspects of neuron-glial interactions. This chapter aims to provide essential knowledge on neuron-glial interactions in the mammalian brain, leveraging on computational studies that focus on structure (anatomy) and function (physiology) of such interactions in the healthy brain. Although our understanding of the need of neuron-glial interactions in the brain is still at its infancy, being mostly based on predictions that await for experimental validation, simple general modeling arguments borrowed from control theory are introduced to support the importance of including such interactions in traditional neuron-based modeling paradigms.Comment: 43 pages, 2 figures, 1 table. Accepted for publication in the "Encyclopedia of Computational Neuroscience," D. Jaeger and R. Jung eds., Springer-Verlag New York, 2020 (2nd edition

    Uso de Arcillas Especiales para Depuración de Aguas Residuales

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    Para evaluar la eficacia de las arcillas especiales para la remoción de metales pesados de aguas residuales, se muestrearon y caracterizaron varios tipos de arcillas y las aguas de tres efluentes residuales industriales. Los componentes mayoritarios de las arcillas fueron: sepiolita: montmorillonita (76%); bentonita magnésica: vermiculita (74,4%); bentonita alumínica: esmectita (69,1%) y paligorskita (80%). Las aguas residuales se hicieron circular a través de lechos de cada una de las arcillas; manteniendo un tiempo de contacto de tres horas. Se analizó el contenido de metales pesados disueltos en las aguas antes y después de pasar a través de cada lecho. La sepiolita y la bentonita magnésica son eficaces para reducir la concentración de metales pesados en aguas residuales industriales. Se concluye que la adsorción depende del pH, del contenido de metales y del contenido de sólidos en suspensión en las agua
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