Monitoring of liquid flow through microtubes using a micropressure sensor

The pressure-driven liquid flow through microtubes was studied in a range of very low Reynolds numbers (<0.15) by monitoring the pressure change in situ. Cylindrical microtubes with diameters ranging from 50 ?m to 500 ?m were examined and two types of tube material, namely PEEK polymer and fused silica were compared. A good linear relation for the pressure drop versus flow rate was obtained. Apparent deviations between the measured slopes with those calculated using conventional theory were attributed to uncertainties in the calculated values which are dominated by the uncertainties in the microtube diameters. It was found that a period of stabilisation time was required for reaching a steady flow after the syringe pump was switched on/off or to a different flow rate. The stabilisation time was likely due to the compressibility of the fluid. Insignificant difference between PEEK polymer and fused silica microtubes in terms of flow resistance was observed. The in-situ measurement of pressure drops provides a convenient approach for monitoring fluid flow through microtubes and detecting dimensional changes within microchannels in Lab-on-a-Chip and microreactor systems

Measurement of cavitation in a sliding bearing using digital holography

This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute, ASME Press, LCN London Centre for Nanotechnology, UCL University College London, UCL Engineering, the International NanoScience Community, www.nanopaprika.eu.Although most of the mathematical models for cavitation in bearings provide reasonable estimates of engineering parameters such as load capacity and friction, they are based on substantially different assumptions and further work is required to understand the fundamental operation of bearings. In this study digital holography was used to examine bubble formation within a glass sliding bearing. Digital holography collects the both the phase and amplitude of the transmitted wavefront and therefore contains quantitative information concerning the thickness of the cavitation bubbles. This paper introduces the experimental configuration and the digital holography system used to study cavitation. It also discusses the demodulation process and how the information can be used to find other interesting parameters such as bubble position and shape

An alternative technique for investigating fluid flow around the hand during front crawl

This paper presents the novel application of a technique for measuring flow around the hand during a simulated swim stroke with a view to enable a better understanding of propulsion generation in swimming. The technique relies on the instantaneous, non-intrusive, volumetric measurement of 3D velocity fields using a commercially available optical measurement system. A hand and forearm model was towed through a water tank to replicate the pull phase with fluid flow data being captured at regular intervals in a fixed volume through which the model moved. The measurement system included a single body, three-sensor probe for capturing pairs of images which were then processed to determine particle velocities and to characterise the flow. The results were used to investigate changes in mean velocity for six experimental cases based on three different angles of attack and two towing speeds. The results showed that the V3V system could be used to capture velocity data around the hand and for a 45° increase in angle of attack, the velocity magnitude of the flow reduced by half, indicating the presence of lift forces. © 2013 The Authors

Holography, tomography and 3D microscopy as linear filtering operations

In this paper we characterise 3D optical imaging techniques as 3D linear shift invariant filtering operations. From the Helmholtz equation that is the basis of scalar diffraction theory we show that the scattered field, or indeed a holographic reconstruction of this field, can be considered to be the result of a linear filtering operation applied to a source distribution. We note that if the scattering is weak, the source distribution is independent of the scattered field and a holographic reconstruction (or in fact any far-field optical imaging system) behaves as a 3D linear shift invariant filter applied to the refractive index contrast (which effectively defines the object). We go on to consider tomographic techniques that synthesise images from recordings of the scattered field using different illumination conditions. In our analysis we compare the 3D response of monochromatic optical tomography with the 3D imagery offered by confocal microscopy and scanning white light interferometry (using with quassi-monochromatic illumination) and explain the circumstances in which these approaches are equivalent. Finally, we consider the 3D response of polychromatic optical tomography and in particular the response of spectral optical coherence tomography and scanning white light interferometry

Use of combined oral contraceptives and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases

Objective To investigate the association between use of combined oral contraceptives and risk of venous thromboembolism, taking the type of progestogen into account. Design Two nested case-control studies. Setting General practices in the United Kingdom contributing to the Clinical Practice Research Datalink (CPRD; 618 practices) and QResearch primary care database (722 practices). Participants Women aged 15-49 years with a first diagnosis of venous thromboembolism in 2001-13, each matched with up to five controls by age, practice, and calendar year. Main outcome measures Odds ratios for incident venous thromboembolism and use of combined oral contraceptives in the previous year, adjusted for smoking status, alcohol consumption, ethnic group, body mass index, comorbidities, and other contraceptive drugs. Results were combined across the two datasets. Results 5062 cases of venous thromboembolism from CPRD and 5500 from QResearch were analysed. Current exposure to any combined oral contraceptive was associated with an increased risk of venous thromboembolism (adjusted odds ratio 2.97, 95% confidence interval 2.78 to 3.17) compared with no exposure in the previous year. Corresponding risks associated with current exposure to desogestrel (4.28, 3.66 to 5.01), gestodene (3.64, 3.00 to 4.43), drospirenone (4.12, 3.43 to 4.96), and cyproterone (4.27, 3.57 to 5.11) were significantly higher than those for second generation contraceptives levonorgestrel (2.38, 2.18 to 2.59) and norethisterone (2.56, 2.15 to 3.06), and for norgestimate (2.53, 2.17 to 2.96). The number of extra cases of venous thromboembolism per year per 10 000 treated women was lowest for levonorgestrel (6, 95% confidence interval 5 to 7) and norgestimate (6, 5 to 8), and highest for desogestrel (14, 11 to 17) and cyproterone (14, 11 to 17). Conclusions In these population based, case-control studies using two large primary care databases, risks of venous thromboembolism associated with combined oral contraceptives were, with the exception of norgestimate, higher for newer drug preparations than for second generation drugs

Optical diffraction tomography in fluid velocimetry: the use of a priori information

Holographic Particle Image Velocimetry (HPIV) has been used successfully to make threedimensional, three-component flow measurements from holographic recordings of seeded fluid. It is clear that measurements can only be made in regions that contain particles, but simply adding more seeding results in poor quality images that suffer from the effects of multiple scattering. Optical Diffraction Tomography provides a means to reconstruct a 3D map of refractive index from coherent recordings of scattered fields with different illumination conditions. Although the Born Approximation limits the applicability of the technique to weakscattering problems, this approach has been used to create three-dimensional images using a Digital Holographic Microscope (DHM). A non-linear optimization technique, the Conjugated Gradient optimisation Method (CGM) has been previously proposed in microwave imaging for strong scattering problems. In this paper we propose a modification of the CGM which uses apriori information to reduce the number of unknown variables that characterize the object to the position of the seeders. Some 2D numerical experiments have been computed, showing promising results and the value of these is fluid velocimetry is discussed

A Technique of Direct Tension Measurement of a Strung Fine Wire

We present a new technique of direct measurement of wire tensions in wire chambers. A specially designed circuit plucks the wire using the Lorentz force and measures the frequency of damped transverse oscillations of the wire. The technique avoids the usual time-consuming necessity of tuning circuit parameter to a resonance. It allows a fast and convenient determination of tensions and is straightforward to implement.Comment: 15 pages with 9 figure