619 research outputs found
Tailoring the frictional properties of granular media
A method of modifying the roughness of soda-lime glass spheres is presented,
with the purpose of tuning inter-particle friction. The effect of chemical
etching on the surface topography and the bulk frictional properties of grains
is systematically investigated. The surface roughness of the grains is measured
using white light interferometry and characterised by the lateral and vertical
roughness length scales. The underwater angle of repose is measured to
characterise the bulk frictional behaviour. We observe that the co-efficient of
friction depends on the vertical roughness length scale. We also demonstrate a
bulk surface roughness measurement using a carbonated soft drink.Comment: 10 pages, 17 figures, submitted to Phys. Rev.
Gravity-driven Dense Granular Flows
We report and analyze the results of numerical studies of dense granular
flows in two and three dimensions, using both linear damped springs and
Hertzian force laws between particles. Chute flow generically produces a
constant density profile that satisfies scaling relations suggestive of a
Bagnold grain inertia regime. The type of force law has little impact on the
behavior of the system. Bulk and surface flows differ in their failure criteria
and flow rheology, as evidenced by the change in principal stress directions
near the surface. Surface-only flows are not observed in this geometry.Comment: 4 pages, RevTeX 3.0, 4 PostScript figures (5 files) embedded with
eps
Rheology of granular flows across the transition from soft to rigid particles
International audienc
Ion Microscopy: A New Approach for Subcellular Localization of Labelled Molecules
Secondary ion mass spectroscopy (SIMS) was used to obtain images representing the intracellular distribution of molecules labelled with carbon 14.
Deoxyadenosine labelled with carbon 14 was added to a cultured human fibroblast cell medium, and the intracellular distribution of this molecule was studied using three different SIMS instruments: the CAMECA IMS 3F and SMI 300 ion microscopes and the UC-HRL scanning ion microprobe.
Carbon 14 distribution images obtained by this method show that deoxyadenosine U-C14 is present in the cytoplasm as well as the nucleus, with a higher concentration in\u27 the nucleoli. Our study clearly demonstrates that ion microscopy is well suited for carbon 14 detection and localization at the subcellular level, permitting a wide variety of microanalytical tracer experiments
miRNA profiles as a predictor of chemoresponsiveness in Wilms' tumor blastema.
The current SIOP treatment protocol for Wilms' tumor involves pre-operative chemotherapy followed by nephrectomy. Not all patients benefit equally from such chemotherapy. The aim of this study was to generate a miRNA profile of chemo resistant blastemal cells in high risk Wilms' tumors which might serve as predictive markers of therapeutic response at the pre-treatment biopsy stage. We have shown here that unsupervised hierarchical clustering of genome-wide miRNA expression profiles can clearly separate intermediate risk tumors from high risk tumors. A total of 29 miRNAs were significantly differentially expressed between post-treatment intermediate risk and high risk groups, including miRNAs that have been previously linked to chemo resistance in other cancer types. Furthermore, 7 of these 29 miRNAs were already at the pre-treatment biopsy stage differentially expressed between cases ultimately deemed intermediate risk compared to high risk. These miRNA alterations include down-regulation in high risk cases of miR-193a.5p, miR-27a and the up-regulation of miR-483.5p, miR-628.5p, miR-590.5p, miR-302a and miR-367. The demonstration of such miRNA markers at the pre-treatment biopsy stage could permit stratification of patients to more tailored treatment regimens
Diphasic non-local model for granular surface flows
Considering recent results revealing the existence of multi-scale rigid
clusters of grains embedded in granular surface flows, i.e. flows down an
erodible bed, we describe here the surface flows rheology through a non-local
constitutive law. The predictions of the resulting model are compared
quantitatively to experimental results: The model succeeds to account for the
counter-intuitive shape of the velocity profile observed in experiments, i.e. a
velocity profile decreasing exponentially with depth in the static phase and
remaining linear in the flowing layer with a velocity gradient independent of
both the flowing layer thickness, the angle between the flow and the
horizontal, and the coefficient of restitution of the grains. Moreover, the
scalings observed in rotating drums are recovered, at least for small rotating
speed.Comment: 7 pages, submitted to Europhys. Let
Stress in frictionless granular material: Adaptive Network Simulations
We present a minimalistic approach to simulations of force transmission
through granular systems. We start from a configuration containing cohesive
(tensile) contact forces and use an adaptive procedure to find the stable
configuration with no tensile contact forces. The procedure works by
sequentially removing and adding individual contacts between adjacent beads,
while the bead positions are not modified. In a series of two-dimensional
realizations, the resulting force networks are shown to satisfy a linear
constraint among the three components of average stress, as anticipated by
recent theories. The coefficients in the linear constraint remain nearly
constant for a range of shear loadings up to about .6 of the normal loading.
The spatial distribution of contact forces shows strong concentration along
``force chains". The probability of contact forces of magnitude f shows an
exponential falloff with f. The response to a local perturbing force is
concentrated along two characteristic rays directed downward and laterally.Comment: 8 pages, 8 figure
Logarithmic rate dependence in deforming granular materials
Rate-independence for stresses within a granular material is a basic tenet of
many models for slow dense granular flows. By contrast, logarithmic rate
dependence of stresses is found in solid-on-solid friction, in geological
settings, and elsewhere. In this work, we show that logarithmic rate-dependence
occurs in granular materials for plastic (irreversible) deformations that occur
during shearing but not for elastic (reversible) deformations, such as those
that occur under moderate repetitive compression. Increasing the shearing rate,
\Omega, leads to an increase in the stress and the stress fluctuations that at
least qualitatively resemble what occurs due to an increase in the density.
Increases in \Omega also lead to qualitative changes in the distributions of
stress build-up and relaxation events. If shearing is stopped at t=0, stress
relaxations occur with \sigma(t)/ \sigma(t=0) \simeq A \log(t/t_0). This
collective relaxation of the stress network over logarithmically long times
provides a mechanism for rate-dependent strengthening.Comment: 4 pages, 5 figures. RevTeX
Introduction to Configuration Path Integral Monte Carlo
In low-temperature high-density plasmas quantum effects of the electrons are
becoming increasingly important. This requires the development of new
theoretical and computational tools. Quantum Monte Carlo methods are among the
most successful approaches to first-principle simulations of many-body quantum
systems. In this chapter we present a recently developed method---the
configuration path integral Monte Carlo (CPIMC) method for moderately coupled,
highly degenerate fermions at finite temperatures. It is based on the second
quantization representation of the -particle density operator in a basis of
(anti-)symmetrized -particle states (configurations of occupation numbers)
and allows to tread arbitrary pair interactions in a continuous space.
We give a detailed description of the method and discuss the application to
electrons or, more generally, Coulomb-interacting fermions. As a test case we
consider a few quantum particles in a one-dimensional harmonic trap. Depending
on the coupling parameter (ratio of the interaction energy to kinetic energy),
the method strongly reduces the sign problem as compared to direct path
integral Monte Carlo (DPIMC) simulations in the regime of strong degeneracy
which is of particular importance for dense matter in laser plasmas or compact
stars. In order to provide a self-contained introduction, the chapter includes
a short introduction to Metropolis Monte Carlo methods and the second
quantization of quantum mechanics.Comment: chapter in book "Introduction to Complex Plasmas: Scientific
Challenges and Technological Opportunities", Michael Bonitz, K. Becker, J.
Lopez and H. Thomsen (Eds.) Springer Series "Atomic, Optical and Plasma
Physics", vol. 82, Springer 2014, pp. 153-194 ISBN: 978-3-319-05436-0 (Print)
978-3-319-05437-7 (Online
Dissipation of vibration in rough contact
The relationship which links the normal vibration occurring during the sliding of rough surfaces and the nominal contact area is investigated. Two regimes are found. In the first one, the vibrational level does not depend on the contact area, while in the second one, it is propor- tional to the contact area. A theoretical model is proposed. It is based on the assumption that the vibrational level results from a competition between two processes of vibration damping, the internal damping of the material and the contact damping occurring at the interface
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