AGENT: Alumni growth and engagement across new technologies

The AGENT project aims to use social networking technologies (LinkedIn and Facebook) to support the development of undergraduates’ employability and career development. The focus of the project is on e-mentoring by alumni to provide a ‘bridge’ between individuals whose social ties and connections are weakened by time and distance, whilst at the same time capitalising on the learning opportunities afforded by the widening of social networks. Social networking sites (SNSs) have been shown to provide students with the tools to make connections, build relationships and support personal development. From a social capital perspective, SNSs can support ‘weak ties’ by allowing students to grow a social network from which to draw resources in the form of information, knowledge, advice and expertise that an institution’s alumni can provide. Alumni are a key resource for building professional networking communities that can provide offline as well as online support to students. We report on an on-going JISC project –AGENT (Alumni Growth and Engagement across New Technologies) that explores how Web 2.0 technologies engage alumni, create the sense of belonging, develop more effective and mutually-beneficial alumni-student connections and associated positive social capital outcomes.Joint Information Systems Committee (JISC) 2011-201

Evaluating telemedicine: A focus on patient pathways

Evaluations of telemedicine have sought to assess various measures of effectiveness (e.g., diagnostic accuracy), efficiency (e.g., cost), and engagement (e.g., patient satisfaction) to determine its success. Few studies, however, have looked at evaluating the organizational impact of telemedicine, which involves technology and process changes that affect the way that it is used and accepted by patients and clinicians alike. This study reviews and discusses the conceptual issues in telemedicine research and proposes a fresh approach for evaluating telemedicine. First, we advance a patient pathway perspective, as most of the existing studies view telemedicine as a support to a singular rather than multiple aspects of a health care process. Second, to conceptualize patient pathways and understand how telemedicine impacts upon them, we propose simulation as a tool to enhance understanding of the traditional and telemedicine patient pathway

Mining social network data for personalisation and privacy concerns: A case study of Facebook’s Beacon

This is the post-print version of the final published paper that is available from the link below.The popular success of online social networking sites (SNS) such as Facebook is a hugely tempting resource of data mining for businesses engaged in personalised marketing. The use of personal information, willingly shared between online friends' networks intuitively appears to be a natural extension of current advertising strategies such as word-of-mouth and viral marketing. However, the use of SNS data for personalised marketing has provoked outrage amongst SNS users and radically highlighted the issue of privacy concern. This paper inverts the traditional approach to personalisation by conceptualising the limits of data mining in social networks using privacy concern as the guide. A qualitative investigation of 95 blogs containing 568 comments was collected during the failed launch of Beacon, a third party marketing initiative by Facebook. Thematic analysis resulted in the development of taxonomy of privacy concerns which offers a concrete means for online businesses to better understand SNS business landscape - especially with regard to the limits of the use and acceptance of personalised marketing in social networks

The therapeutic benefit of vasodilators in acute heart failure: absence of evidence or evidence of absence?

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Social Media: The Law Simply Stated

It is a challenge to simply state the law about social media, because there is no such thing as “social media law.” Rather, the law bumps up against social media in many ways. In some cases, existing law can be seamlessly applied to new technologies and means of interaction. In other cases, entirely new paradigms will likely need to be adopted to handle new challenges. Many other cases will fall somewhere in between. Our goal in this Law Simply Stated is to provide some background on the nature of social media themselves, and then to state the basic law in a number of applicable fields. In particular we shall begin with discussion of the definition of “social media,” along with consideration of what we see as an important analytical theme: is this topic a topic? Do the challenges posed by social media have a single solution? Are they matters to which the law can simply adapt, or must new approaches be created? Can the same answer be provided in each context? Following that we will move to discuss basic principles of law in a variety of areas which are relevant to social media. These are: judicial notice; courtroom management; civil discovery; privacy; admissibility of electronic documents; criminal evidence-gathering; employment law; defamation; and finally, cyber-bullying

Single-leg airline revenue management with overbooking

Airline revenue management is about identifying the maximum revenue seat allocation policies. Since a major loss in revenue results from cancellations and no-show passengers, over the years overbooking has received a significant attention in the literature. In this study, we propose new models for static and dynamic single-leg overbooking problems. In the static case, we introduce computationally tractable models that give upper and lower bounds for the optimal expected revenue. In the dynamic case, we propose a new dynamic programming model, which is based on two streams of arrivals. The first stream corresponds to the booking requests and the second stream represents the cancellations. We also conduct simulation experiments to illustrate the proposed models and the solution methods

β-Estradiol-dependent activation of the JAK/STAT pathway requires p/CIP and CARM1

The steroid receptor coactivator p/CIP, also known as SRC-3, is an oncogene commonly amplified in breast and ovarian cancers. p/CIP is known to associate with coactivator arginine methyltransferase 1 (CARM1) on select estrogen responsive genes. We have shown, using a ChIP-on-chip approach, that in response to stimulation with 17β-estradiol (E2), the p/CIP/CARM1 complex is recruited to 204 proximal promoters in MCF-7 cells. Many of the complex target genes have been previously implicated in signaling pathways related to oncogenesis. Jak2, a member of the Jak/Stat signaling cascade, is one of the direct E2-dependent targets of the p/CIP/CARM1 complex. Following E2-treatment, histone modifications at the Jak2 promoter are reflective of a transcriptionally permissive gene, and modest changes in RNA and protein expression lead us to suggest that an additional factor(s) may be required for a more notable transcriptional and functional response. Bioinformatic examination of the 204 proximal promoter sequences of p/CIP/CARM1 targets supports the idea that transcription factor crosstalk is likely the favored mechanism of E2-dependent p/CIP/CARM1 complex recruitment. This data may have implications towards understanding the oncogenic role of p/CIP in breast cancer and ultimately allow for the identification of new prognostic indicators and/or viable therapeutic targets. © 2013