On the motion of a heavy rigid body in an ideal fluid with circulation

Chaplygin's equations describing the planar motion of a rigid body in an unbounded volume of an ideal fluid involved in a circular flow around the body are considered. Hamiltonian structures, new integrable cases, and partial solutions are revealed, and their stability is examined. The problems of non-integrability of the equations of motion because of a chaotic behavior of the system are discussed.Comment: 25 pages, 4 figure

L’hypoxie augmente la production de citrulline par les entérocytes humains : étude in vitro

International audienceIl est maintenant bien établi que la citrulline (CIT) plasmatique est un excellent marqueur de la fonctionnalité intestinale, en particulier chez les patients de réanimation où elle est généralement effondrée [1]. Or, les mécanismes impliqués ne sont pas connus. Nous proposons que l’hypoxie et l’inflammation observées dans ces situations pourraient impacter négativement la production de CIT. L’objectif de cette étude est donc de déterminer, in vitro, si l’hypoxie et l’inflammation ont des effets sur la production de CIT par l’ornithine transcarbamylase (OTC). Ces effets ont été évalués en utilisant un modèle d’incubation d’explant duodénal humain [2]. Le protocole a été approuvé par le comité de protection des personnes du CHU de Grenoble

OR14: Obstructive Sleep Apnea and Malnutrition: A Preliminary Study

International audienc

Reduction and follow-up of hospital discharge letter delay using Little's law.

As discharge letters (DL) hold important information for healthcare professionals and especially for general practitioners, rapid and efficient finalization is required. We describe a project aiming to reduce DL submission within 8 days in our Urology Department (UD), as required by the local Hospital Board (HB). A team was built in UD with staff members and one external expert to study the root causes of delayed DL creation and develop sustainable strategies to improve and monitor the process, including habits changing, training and application of Little's Law. The study started on January 2015 and ended up on March 2016, involving 908 and 616 DL for old and new process, respectively. The new process decreased the average delay of DL completion from 24.88 days to 14.7 days. Standard deviation of total average delay for DL completion fell from 10.1 days to 7.5 days. We identified four steps needed to DL creation and allowed maximum 2 days for every step completion. No additional resources were employed. We were able to improve the process of DL creation, by analysing its steps and reducing their variability. This can be easily transposed to other medical departments

Impaired phosphocreatine metabolism in white adipocytes promotes inflammation.

The mechanisms promoting disturbed white adipocyte function in obesity remain largely unclear. Herein, we integrate white adipose tissue (WAT) metabolomic and transcriptomic data from clinical cohorts and find that the WAT phosphocreatine/creatine ratio is increased and creatine kinase-B expression and activity is decreased in the obese state. In human in vitro and murine in vivo models, we demonstrate that decreased phosphocreatine metabolism in white adipocytes alters adenosine monophosphate-activated protein kinase activity via effects on adenosine triphosphate/adenosine diphosphate levels, independently of WAT beigeing. This disturbance promotes a pro-inflammatory profile characterized, in part, by increased chemokine (C-C motif) ligand 2 (CCL2) production. These data suggest that the phosphocreatine/creatine system links cellular energy shuttling with pro-inflammatory responses in human and murine white adipocytes. Our findings provide unexpected perspectives on the mechanisms driving WAT inflammation in obesity and may present avenues to target adipocyte dysfunction