A high-resolution Holocene fault activity history of the Aigion Shelf, Gulf of Corinth, Greece

The Gulf of Corinth is a continental rift in the western Aegean, Greece. It is the most active rift basin in Europe, with maximum N-S extension rates across the rift of ~15 mm yr-1. The data presented in this thesis reveal the behaviour of the Aigion Shelf Fault, part of one of the active normal fault systems in the Gulf of Corinth, over the past ~12 kyr, using high-resolution seismic reflection and multibeam bathymetry datasets.The Aigion Shelf Fault is part of an en echelon system comprising four basin bounding faults that control the southern margin of the Gulf of Corinth. It is a segmented, N-dipping normal fault, which overlaps and is active concurrently with the older Western Eliki Fault. It forms the southern boundary to a graben structure that narrows eastwards, which is bounded to the north by a S-dipping segmented fault. Approximately 500 m west of the shelf edge the graben geometry changes, with the Aigion Shelf Fault stepping north, and the S-dipping fault switching polarity to become N-dipping.Sequence stratigraphic markers relating to the post-lowstand transgression and more recent progradational beach deltaics form the boundaries between three distinct seismic packages, enabling quantification of fault slip rates and changes in sediment deposition. Isopachs from five specific time periods show that the development of depocentres is predominantly controlled by faulting.Displacement on the Aigion Shelf is distributed over a complex fault population. This is interpreted as a damage zone associated with the eastern tip of the Aigion Shelf Fault, formed through upward bifurcation of fault splays from a single structure at depth. The combined spatially averaged total slip rate for all the splays identified is 2.6 0.4 mm yr ± -1. The average vertical displacement rate on the Aigion Shelf Fault is ~0.6 0.1 mm yr ± -1. Significant short-term spatial and temporal variability within the 12 kyr time period suggests the influence of segment boundaries, and periods of enhanced activity over 1 kyr timescales representing multiple earthquake cycles. Observation periods of >4 kyr are found to represent the longer-term displacement behaviour on the Aigion Shelf Fault.The displacement profile of the Aigion Shelf Fault indicates that it is extends onshore. There is no apparent structural link between the main Aigion and Aigion Shelf Faults. However, a similarity in displacement rates and profiles suggest that both are immature structures that form part of the larger Aigion-Neos Erineos Fault system. Fault structure plots indicate that there has been no lateral fault growth over the Holocene, with burial and mortality of minor faults. Formation of growth wedges against both the Aigion Shelf Fault and S-dipping graben bounding fault indicate that the relative dominance of both faults has varied spatially and temporally

Modern pollution signals in sediments from Windermere, NW England, determined by micro-XRF and lead isotope analysis

High resolution geochemical (Itrax micro-XRF and wavelength dispersive XRF) data, radiochronology (210Pb and 137Cs analyses) and ultra-high precision double-spike lead isotope measurements from lacustrine sediment cores are used in combination with historical research of former mining landscapes to investigate modern pollution signals in sediments from Windermere, the largest lake in the English Lake District. The sediment record suggests that while most element concentrations have been stable, there has been a significant increase since the 1930s in lead, zinc and copper concentrations. Double-spike lead isotope measurements reveal a mixture of natural lead, and three major contributory sources of anthropogenic (industrial) lead, comprising gasoline lead, coal combustion lead (from coal-fired steam ships) and lead derived from Carboniferous Pb–Zn mineralisation (mining activities). A number of up-system sediment traps have limited the amount of mining related heavy metals entering Windermere, and as a result, periods of metal workings do not correlate with peaks in heavy metals. Increases could also be due to flood-induced metal inwash or weathering of bedrock in the catchment. Application of these non-destructive and high precision analytical techniques provides new insights into the pollutant depositional history of Windermere

A 500 year sediment lake record of anthropogenic and natural inputs to Windermere (English Lake District) using double-spike lead isotopes, radiochronology, and sediment microanalysis

A high-resolution record of pollution is preserved in recent sediments from Windermere, the largest lake in the English Lake District. Data derived from X-ray core scanning (validated against wavelength dispersive X-ray fluorescence), radiochronological techniques (210Pb and 137Cs) and ultrahigh precision, double-spike mass spectrometry for lead isotopes are combined to decipher the anthropogenic inputs to the lake. The sediment record suggests that while most element concentrations have been stable, there has been a significant increase in lead, zinc, and copper concentrations since the 1930s. Lead isotope down-core variations identify three major contributory sources of anthropogenic (industrial) lead, comprising gasoline lead, coal combustion lead (most likely source is coal-fired steam ships), and lead derived from Carboniferous Pb–Zn mineralization (mining activities). Periods of metal workings do not correlate with peaks in heavy metals due to the trapping efficiency of up-system lakes in the catchment. Heavy metal increases could be due to flood-induced metal inwash after the cessation of mining and the weathering of bedrock in the catchment. The combination of sediment analysis techniques used provides new insights into the pollutant depositional history of Windermere and could be similarly applied to other lake systems to determine the timing and scale of anthropogenic inputs

Geometry and slip rate of the Aigion fault, a young normal fault system in the western Gulf of Corinth

The Aigion fault is one of the youngest major normal faults in the Gulf of Corinth, Greece, with an immature displacement profile. Based on geometry, slip rate and comparison with regional faults, we estimate the fault system length at ~10 km. We find the slip rate of the fault system is ~3.5 ± 1 mm/yr decreasing to ~2.5 ± 0.7 mm/yr close to its eastern tip. Complex fault geometry and displacement profiles on the shelf east of Aigion are consistent with the latter as the eastern tip location. Analysis of slip on this fault system and the established fault to the south (Western Eliki Fault) suggests that slip was transferred rapidly but not homogeneously between the two faults during the period of contemporaneous activity. Together with a lack of evidence of lateral propagation at the eastern fault tip in the last 10–13 k.y., we suggest that the fault developed and established its current length rapidly, within its 200–300 k.y. history. These results contribute to our understanding of the process of northward fault migration into the rift and the development of new normal faults

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Background: In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation. Methods: This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. Those trial participants with hypoxia (oxygen saturation <92% on air or requiring oxygen therapy) and evidence of systemic inflammation (C-reactive protein ≥75 mg/L) were eligible for random assignment in a 1:1 ratio to usual standard of care alone versus usual standard of care plus tocilizumab at a dose of 400 mg–800 mg (depending on weight) given intravenously. A second dose could be given 12–24 h later if the patient's condition had not improved. The primary outcome was 28-day mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN (50189673) and ClinicalTrials.gov (NCT04381936). Findings: Between April 23, 2020, and Jan 24, 2021, 4116 adults of 21 550 patients enrolled into the RECOVERY trial were included in the assessment of tocilizumab, including 3385 (82%) patients receiving systemic corticosteroids. Overall, 621 (31%) of the 2022 patients allocated tocilizumab and 729 (35%) of the 2094 patients allocated to usual care died within 28 days (rate ratio 0·85; 95% CI 0·76–0·94; p=0·0028). Consistent results were seen in all prespecified subgroups of patients, including those receiving systemic corticosteroids. Patients allocated to tocilizumab were more likely to be discharged from hospital within 28 days (57% vs 50%; rate ratio 1·22; 1·12–1·33; p<0·0001). Among those not receiving invasive mechanical ventilation at baseline, patients allocated tocilizumab were less likely to reach the composite endpoint of invasive mechanical ventilation or death (35% vs 42%; risk ratio 0·84; 95% CI 0·77–0·92; p<0·0001). Interpretation: In hospitalised COVID-19 patients with hypoxia and systemic inflammation, tocilizumab improved survival and other clinical outcomes. These benefits were seen regardless of the amount of respiratory support and were additional to the benefits of systemic corticosteroids. Funding: UK Research and Innovation (Medical Research Council) and National Institute of Health Research

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

Background: Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19. Methods: This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. The trial is underway at 177 NHS hospitals from across the UK. Eligible and consenting patients were randomly assigned (1:1) to receive either usual care alone (usual care group) or usual care plus high-titre convalescent plasma (convalescent plasma group). The primary outcome was 28-day mortality, analysed on an intention-to-treat basis. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936. Findings: Between May 28, 2020, and Jan 15, 2021, 11558 (71%) of 16287 patients enrolled in RECOVERY were eligible to receive convalescent plasma and were assigned to either the convalescent plasma group or the usual care group. There was no significant difference in 28-day mortality between the two groups: 1399 (24%) of 5795 patients in the convalescent plasma group and 1408 (24%) of 5763 patients in the usual care group died within 28 days (rate ratio 1·00, 95% CI 0·93–1·07; p=0·95). The 28-day mortality rate ratio was similar in all prespecified subgroups of patients, including in those patients without detectable SARS-CoV-2 antibodies at randomisation. Allocation to convalescent plasma had no significant effect on the proportion of patients discharged from hospital within 28 days (3832 [66%] patients in the convalescent plasma group vs 3822 [66%] patients in the usual care group; rate ratio 0·99, 95% CI 0·94–1·03; p=0·57). Among those not on invasive mechanical ventilation at randomisation, there was no significant difference in the proportion of patients meeting the composite endpoint of progression to invasive mechanical ventilation or death (1568 [29%] of 5493 patients in the convalescent plasma group vs 1568 [29%] of 5448 patients in the usual care group; rate ratio 0·99, 95% CI 0·93–1·05; p=0·79). Interpretation: In patients hospitalised with COVID-19, high-titre convalescent plasma did not improve survival or other prespecified clinical outcomes. Funding: UK Research and Innovation (Medical Research Council) and National Institute of Health Research

Seismic stratigraphy records the deglacial history of Jakobshavn Isbrae, West Greenland

Jakobshavn Isbræ is one of the largest ice streams in the Greenland Ice Sheet, presently draining c. 6.5% of the Inland Ice. Here we present high-resolution Chirp and Sparker sub-bottom profiles from a seismic survey conducted just outside of the Jakobshavn Isfjord, which provides detailed insight into the glacimarine sedimentary history of the Jakobshavn ice stream during the Holocene. We observe acoustically stratified and homogeneous sediments that drape an irregular substratum and were deposited between ∼10 and c. 7.6k cal a BP. The stratified lower units are interpreted as the product of ice-proximal glacimarine sedimentation deposited rapidly when the grounded ice margin was located close to depositional basins on topographic highs. The upper acoustically homogenous units reflect suspension settling of fine-grained material and gravitational flows that were extruded from an increasingly unstable ice margin as the ice retreated into the fjord. Proximity to the ice margin and bedrock topography were the dominant controls on sediment accumulation during deglaciation although the 8.2-ka cooling event probably influenced the position of the ice margin at the fjord mouth. The post-glacial sedimentary record is characterized by glacimarine and hemipelagic rainout with an increased ice-rafted detritus fraction that records sedimentation following ice stream retreat into Jakobshavn Isfjord sometime after c. 7.8k cal a BP