Densities and phase equilibria of hydrogen, propane and vegetable oil mixtures. Experimental data and thermodynamic modeling

Heterogeneous catalytic gas-liquid reactions are intensified when carried out in the homogenous fluid phase by means of a supercritical co-solvent. For instance, supercritical propane is used to enhance yield in the hydrogenation of vegetable oils. Besides phase equilibrium knowledge, volumetric information is also needed to elucidate kinetic mechanisms and design continuous supercritical reactors. In this work, we report new experimental PvT data of the reactive mixture H2+sunflower oil+propane using the isochoric method. In addition, the phase equilibria and PvT data are modeled with the GCA and RK-PR equations of state, respectively. The isochoric method not only provides PvT information under the reaction conditions, but also the reactive system compressibility, key variable to attain enhanced transport properties in the supercritical reactors.Fil: Hegel, Pablo Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Cotabarren, Natalia Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Brignole, Esteban Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Pereda, Selva. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. University of KwaZulu-Natal; Sudáfric

Anticancer activity of protein fractions from chia (Salvia hispanica L.)

Salvia hispanica demonstrated to be a source of protein fractions with anticancer activity. The effect of the protein fractions <1, 1–3, and 3–5 kDa, obtained by ultrafiltration of the S. hispanica hydrolysate, was evaluated on the cellular viability of four cancer cell lines (MCF-7, Caco2, PC-3, and HepG2) and on human fibroblasts (hFB) at different concentrations (0.25, 0.5, 0.75, and 1 mg/ml). The protein fractions did not show cytotoxic effects on hFB. The protein fraction <1 kDa at 1 mg/ml showed the highest statistical effect on the cellular viability of all evaluated cancer lines; thus, its amino acid sequence was analyzed. From the multicriteria decision analysis of the peptide sequences obtained by mass spectrometry, the peptide KLKKNL with potential anticancer activity was selected. In conclusion, protein fractions could represent a therapeutic option for cancer treatment. However, further investigations are necessary to establish conclusive arguments