4 research outputs found
Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND) : a double-blind, randomised, phase 3 study
- Author
- Achiron Anat
- Achtnichts Lutz
- Agan Kadriye
- Akman-Demir Gulsen
- Allen Alison B
- Antel Jack P
- Antiguedad Alfredo Rodriguez
- Apperson Michelle
- Applebee Angela M
- Arnold Douglas L
- Arnould Sophie
- Ayuso Guillermo Izquierdo
- Baba Masayuki
- Bajenaru Ovidiu
- Balasa Rodica
- Balci Belgin Petek
- Bar-Or Amit
- Barnett Michael
- Bass Ann
- Becker Veit U
- Bejinariu Mihaela
- Bergh Florian Then
- Bergmann Arnfin
- Bernitsas Evanthia
- Berthele Achim
- Bhan Virender
- Bischof Felix
- Bjork Randall John
- Blevins Gregg
- Boehringer Matthias
- Boerner Thomas
- Bonek Robert
- Bowen James D
- Bowling Allen
- Boyko Alexey N
- Boz Cavit
- Bracknies Vera
- Braune Stefan
- Brescia Morra Vincenzo
- Brochet Bruno
- Brola Waldemar
- Brownstone Paul Kenneth
- Brozman Miroslav
- Brunet Donald
- Buraga Ioan
- Burnett Margaret
- Buttmann Mathias
- Butzkueven Helmut
- Cahill Jonathan
- Calkwood Jonathan C
- Camu William
- Cascione Mark
- Castelnovo Giovani
- Centonze Diego
- Cerqueira Joao
- Chan Andrew
- Cimprichova Andrea
- Cohan Stanley
- Comi Giancarlo
- Conway Jill
- Cooper Joanna A
- Corboy John
- Correale Jorge
- Costell Brian
- Cottrell David A
- Coyle Patricia K
- Craner Matthew
- Cree Bruce A C
- Cui Liying
- Cunha Luis
- Czlonkowska Anna
- da Silva Ana Martins
- Dahlke Frank
- de Sa Joao
- de Seze J\ue9r\uf4me
- Debouverie Marc
- Debruyne Jan
- Decoo Danny
- Defer Gilles
- Derfuss Tobias
- Deri Norma H
- Dihenia Bhupesh
- Dioszeghy Peter
- Donath Vladimir
- Dubois Benedicte
- Duddy Martin
- Duquette Pierre
- Edan Gilles
- Efendi Husnu
- Elias Stanton
- Emrich Peter J
- Estruch Bonaventura Casanova
- Evdoshenko Evgeniy P
- Faiss Juergen
- Fedyanin Alexander S
- Feneberg Wolfgang
- Fermont Jiske
- Fernandez Oscar Fernandez
- Ferrer Francisco Coret
- Fink Katharina
- Ford Corey
- Ford Helen
- Fox Robert J
- Francia Ada
- Freedman Mark
- Frishberg Benjamin
- Galgani Simonetta
- Garmany George P
- Gehring Klaus
- Giovannoni Gavin
- Gitt Jeffrey
- Gobbi Claudio
- Gold Ralf
- Goldstick Lawrence P
- Gonzalez Rafael Arroyo
- Grandmaison Francois
- Grigoriadis Nikolaos
- Grigorova Olga
- Grimaldi Luigi Maria Edoardo
- Gross Jeffrey
- Gross-Paju Katrin
- Gudesblatt Mark
- Guillaume Daniel
- Haas Judith
- Hancinova Viera
- Hancu Anca
- Hardiman Orla
- Harmjanz Arndt
- Heidenreich Fedor R
- Hengstman G J D
- Herbert Joseph
- Herring Mark
- Hodgkinson Suzanne
- Hoffmann Olaf M
- Hofmann Werner E
- Honeycutt William D
- Hua Le Hanh
- Huang Dehui
- Huang DeRen
- Huang Yining
- Hupperts Raymond
- Imre Piroska
- Jacobs Alan Keith
- Jakab Gabor
- Jasinska Elzbieta
- Kaida Kenichi
- Kalnina Jolanta
- Kappos Ludwig
- Kaprelyan Ara
- Karelis Guntis
- Karussis Dimitrios
- Katz Amos
- Khabirov Farit A
- Khatri Bhupendra
- Kimura Takashi
- Kister Ilya
- Kizlaitiene Rasa
- Klimova Eleonora
- Koehler Juergen
- Komatineni Aparna
- Kornhuber Anselm
- Kovacs Krisztina
- Koves Agnes
- Kozubski Wojciech
- Krastev Georgi
- Krupp Lauren B
- Kurca Egon
- Lassek Christoph
- Laureys Guy
- Lee Liesly
- Lensch Eckart
- Leutmezer Fritz
- Li Hongzeng
- Linker Ralf A
- Linnebank Michael
- Liskova Petra
- Llanera Cristina
- Lu Jiahong
- Lutterotti Andreas
- Lycke Jan
- Macdonell Richard
- Maciejowski Maciej
- Maeurer Mathias
- Magzhanov Rim V
- Maida Eva-Maria
- Malciene Lina
- Mao-Draayer Yang
- Marfia Girolama Alessandra
- Markowitz Clyde
- Mastorodimos Vasileios
- Matyas Klotild
- Meca-Lallana Jose
- Merino Juan Antonio Garcia
- Mihetiu Ioan Gheorghe
- Milanov Ivan
- Miller Aaron E
- Millers Andrejs
- Mirabella Massimiliano
- Mizuno Masanori
- Montalban Xavier
- Montoya Lilina
- Mori Masahiro
- Mueller Stefanie
- Nakahara Jin
- Nakatsuji Yuji
- Newsome Scott
- Nicholas Richard
- Nielsen A Scott
- Nikfekr Esmaeil
- Nocentini Ugo
- Nohara Chiyoko
- Nomura Kyoichi
- Odinak Miroslav M
- Olsson Tomas
- Oreja-Guevara Celia
- Oschmann Patrick
- Overell James
- Pachner Andrew
- Panczel Gyula
- Pandolfo Massimo
- Papeix Caroline
- Patrucco Liliana
- Pelletier Jean
- Piedrabuena Raul
- Pless Misha
- Polzer Udo
- Pozsegovits Krisztian
- Rastenyte Daiva
- Rauer Sebastian
- Reifschneider Gerd
- Rey Roberto
- Rizvi Syed A
- Robertson Derrick
- Rodriguez Jose Martinez
- Rog David
- Roshanisefat Homayoun
- Rowe Vernon
- Rozsa Csilla
- Rubin Susan
- Rusek Stanislaw
- Sacc\ue0 Francesco
- Saida Takahiko
- Salgado Antonio Vasco
- Sanchez Victoria Eugenia Fernandez
- Sanders Kalina
- Satori Maria
- Sazonov Denis V
- Scarpini Elio Angelo
- Scherz Tatiana
- Schlegel Eugen
- Schluep Myriam
- Schmidt Stephan
- Scholz Erich
- Schrijver H M
- Schwab Matthias
- Schwartz Raymond
- Scott James
- Selmaj Krzysztof
- Shafer Stuart
- Sharrack Basil
- Shchukin Ivan A
- Shimizu Yuko
- Shotekov Penko
- Siever Arno
- Sigel Karl-Otto
- Silliman Scott
- Simo Magdolna
- Simu Mihaela
- Sinay Vladimiro
- Siquier Antonio Escartin
- Siva Aksel
- Skoda Ondrej
- Solomon Andrew
- Stangel Martin
- Stefoski Dusan
- Steingo Brian
- Stolyarov Igor D
- Stourac Pavel
- Strassburger-Krogias Katrin
- Strauss Erik
- Stuve Olaf
- Tarnev Ivaylo
- Tavernarakis Antonios
- Tello Cristina Ramo
- Terzi Murat
- Ticha Veronika
- Ticmeanu Marina
- Tiel-Wilck Klaus
- Toomsoo Toomas
- Tubridy Niall
- Tullman Mark J
- Tumani Hayrettin
- Turcani Peter
- Turner Ben
- Uccelli Antonio
- Urtaza Francisco Javier Olascoaga
- Vachova Marta
- Valikovics Attila
- van Oosten B W
- Van Wijmeersch Bart
- Vanopdenbosch Ludo
- Vermersch Patrick
- Vermersch Patrick
- Visser L H
- Vorobeychik Galina
- Wallstr\uf6m Erik
- Walter Silke
- Weber Joerg R
- Weiss Sara
- Weissert Robert
- West Timothy
- Wiendl Heinz
- Wiertlewski Sandrine
- Wildemann Brigitte
- Willekens Barbara
- Wolf Christian
- Xu Xianhao
- Yamamura Takashi
- Yang Yi N
- Yelamos Sergio Martinez
- Yeung Michael
- Zacharias Alan
- Zelkowitz Marvin
- Zettl Uwe
- Zhang Meini
- Zhou Hongyu
- Zieman Ulf
- Ziemssen Tjalf
- Publication venue
- Publication date
- 01/01/2018
- Field of study
Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study
- Author
- Achiron Anat
- Achtnichts Lutz
- Agan Kadriye
- Akman-Demir Gulsen
- Allen Alison B
- Antel Jack P
- Antiguedad Alfredo Rodriguez
- Apperson Michelle
- Applebee Angela M
- Arnold Douglas L
- Arnould Sophie
- Ayuso Guillermo Izquierdo
- Baba Masayuki
- Bajenaru Ovidiu
- Balasa Rodica
- Balci Belgin Petek
- Bar-Or Amit
- Barnett Michael
- Bass Ann
- Becker Veit U
- Bejinariu Mihaela
- Bergh Florian Then
- Bergmann Arnfin
- Bernitsas Evanthia
- Berthele Achim
- Bhan Virender
- Bischof Felix
- Bjork Randall John
- Blevins Gregg
- Boehringer Matthias
- Boerner Thomas
- Bonek Robert
- Bowen James D
- Bowling Allen
- Boyko Alexey N
- Boz Cavit
- Bracknies Vera
- Braune Stefan
- Brescia Morra Vincenzo
- Brochet Bruno
- Brola Waldemar
- Brownstone Paul Kenneth
- Brozman Miroslav
- Brunet Donald
- Buraga Ioan
- Burnett Margaret
- Buttmann Mathias
- Butzkueven Helmut
- Cahill Jonathan
- Calkwood Jonathan C
- Camu William
- Cascione Mark
- Castelnovo Giovani
- Centonze Diego
- Cerqueira Joao
- Chan Andrew
- Cimprichova Andrea
- Cohan Stanley
- Comi Giancarlo
- Conway Jill
- Cooper Joanna A
- Corboy John
- Correale Jorge
- Costell Brian
- Cottrell David A
- Coyle Patricia K
- Craner Matthew
- Cree Bruce A C
- Cui Liying
- Cunha Luis
- Czlonkowska Anna
- da Silva Ana Martins
- Dahlke Frank
- de Sa Joao
- de Seze Jérôme
- Debouverie Marc
- Debruyne Jan
- Decoo Danny
- Defer Gilles
- Derfuss Tobias
- Deri Norma H
- Dihenia Bhupesh
- Dioszeghy Peter
- Donath Vladimir
- Dubois Benedicte
- Duddy Martin
- Duquette Pierre
- Edan Gilles
- Efendi Husnu
- Elias Stanton
- Emrich Peter J
- Estruch Bonaventura Casanova
- Evdoshenko Evgeniy P
- Faiss Juergen
- Fedyanin Alexander S
- Feneberg Wolfgang
- Fermont Jiske
- Fernandez Oscar Fernandez
- Ferrer Francisco Coret
- Fink Katharina
- Ford Corey
- Ford Helen
- Fox Robert J
- Francia Ada
- Freedman Mark
- Frishberg Benjamin
- Galgani Simonetta
- Garmany George P
- Gehring Klaus
- Giovannoni Gavin
- Gitt Jeffrey
- Gobbi Claudio
- Gold Ralf
- Goldstick Lawrence P
- Gonzalez Rafael Arroyo
- Grandmaison Francois
- Grigoriadis Nikolaos
- Grigorova Olga
- Grimaldi Luigi Maria Edoardo
- Gross Jeffrey
- Gross-Paju Katrin
- Gudesblatt Mark
- Guillaume Daniel
- Haas Judith
- Hancinova Viera
- Hancu Anca
- Hardiman Orla
- Harmjanz Arndt
- Heidenreich Fedor R
- Hengstman G J D
- Herbert Joseph
- Herring Mark
- Hodgkinson Suzanne
- Hoffmann Olaf M
- Hofmann Werner E
- Honeycutt William D
- Hua Le Hanh
- Huang Dehui
- Huang Deren
- Huang Yining
- Hupperts Raymond
- Imre Piroska
- Jacobs Alan Keith
- Jakab Gabor
- Jasinska Elzbieta
- Kaida Kenichi
- Kalnina Jolanta
- Kappos Ludwig
- Kaprelyan Ara
- Karelis Guntis
- Karussis Dimitrios
- Katz Amos
- Khabirov Farit A
- Khatri Bhupendra
- Kimura Takashi
- Kister Ilya
- Kizlaitiene Rasa
- Klimova Eleonora
- Koehler Juergen
- Komatineni Aparna
- Kornhuber Anselm
- Kovacs Krisztina
- Koves Agnes
- Kozubski Wojciech
- Krastev Georgi
- Krupp Lauren B
- Kurca Egon
- Lassek Christoph
- Laureys Guy
- Lee Liesly
- Lensch Eckart
- Leutmezer Fritz
- Li Hongzeng
- Linker Ralf A
- Linnebank Michael
- Liskova Petra
- Llanera Cristina
- Lu Jiahong
- Lutterotti Andreas
- Lycke Jan
- Macdonell Richard
- Maciejowski Maciej
- Maeurer Mathias
- Magzhanov Rim V
- Maida Eva-Maria
- Malciene Lina
- Mao-Draayer Yang
- Marfia Girolama Alessandra
- Markowitz Clyde
- Mastorodimos Vasileios
- Matyas Klotild
- Meca-Lallana Jose
- Merino Juan Antonio Garcia
- Mihetiu Ioan Gheorghe
- Milanov Ivan
- Miller Aaron E
- Millers Andrejs
- Mirabella Massimiliano
- Mizuno Masanori
- Montalban Xavier
- Montoya Lilina
- Mori Masahiro
- Mueller Stefanie
- Nakahara Jin
- Nakatsuji Yuji
- Newsome Scott
- Nicholas Richard
- Nielsen A Scott
- Nikfekr Esmaeil
- Nocentini Ugo
- Nohara Chiyoko
- Nomura Kyoichi
- Odinak Miroslav M
- Olsson Tomas
- Oreja-Guevara Celia
- Oschmann Patrick
- Overell James
- Pachner Andrew
- Panczel Gyula
- Pandolfo Massimo
- Papeix Caroline
- Patrucco Liliana
- Pelletier Jean
- Piedrabuena Raul
- Pless Misha
- Polzer Udo
- Pozsegovits Krisztian
- Rastenyte Daiva
- Rauer Sebastian
- Reifschneider Gerd
- Rey Roberto
- Rizvi Syed A
- Robertson Derrick
- Rodriguez Jose Martinez
- Rog David
- Roshanisefat Homayoun
- Rowe Vernon
- Rozsa Csilla
- Rubin Susan
- Rusek Stanislaw
- Saccà Francesco
- Saida Takahiko
- Salgado Antonio Vasco
- Sanchez Victoria Eugenia Fernandez
- Sanders Kalina
- Satori Maria
- Sazonov Denis V
- Scarpini Elio Angelo
- Scherz Tatiana
- Schlegel Eugen
- Schluep Myriam
- Schmidt Stephan
- Scholz Erich
- Schrijver H M
- Schwab Matthias
- Schwartz Raymond
- Scott James
- Selmaj Krzysztof
- Shafer Stuart
- Sharrack Basil
- Shchukin Ivan A
- Shimizu Yuko
- Shotekov Penko
- Siever Arno
- Sigel Karl-Otto
- Silliman Scott
- Simo Magdolna
- Simu Mihaela
- Sinay Vladimiro
- Siquier Antonio Escartin
- Siva Aksel
- Skoda Ondrej
- Solomon Andrew
- Stangel Martin
- Stefoski Dusan
- Steingo Brian
- Stolyarov Igor D
- Stourac Pavel
- Strassburger-Krogias Katrin
- Strauss Erik
- Stuve Olaf
- Tarnev Ivaylo
- Tavernarakis Antonios
- Tello Cristina Ramo
- Terzi Murat
- Ticha Veronika
- Ticmeanu Marina
- Tiel-Wilck Klaus
- Toomsoo Toomas
- Tubridy Niall
- Tullman Mark J
- Tumani Hayrettin
- Turcani Peter
- Turner Ben
- Uccelli Antonio
- Urtaza Francisco Javier Olascoaga
- Vachova Marta
- Valikovics Attila
- van Oosten B W
- Van Wijmeersch Bart
- Vanopdenbosch Ludo
- Vermersch Patrick
- Vermersch Patrick
- Visser L H
- Vorobeychik Galina
- Wallström Erik
- Walter Silke
- Weber Joerg R
- Weiss Sara
- Weissert Robert
- West Timothy
- Wiendl Heinz
- Wiertlewski Sandrine
- Wildemann Brigitte
- Willekens Barbara
- Wolf Christian
- Xu Xianhao
- Yamamura Takashi
- Yang Yi N
- Yelamos Sergio Martinez
- Yeung Michael
- Zacharias Alan
- Zelkowitz Marvin
- Zettl Uwe
- Zhang Meini
- Zhou Hongyu
- Zieman Ulf
- Ziemssen Tjalf
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
International audienc
Donanemab in early symptomatic Alzheimer disease : the TRAILBLAZER-ALZ 2 randomized clinical trial
- Author
- Abreu Rafael
- Agarwal Pinky
- Aggarwal Puja
- Agronin Marc
- Allen Alison
- Altamirano Dario
- Alva Gustavo
- Andersen James
- Anderson Allan
- Anderson Donald
- Apostolova Liana G.
- Ardayfio Paul
- Arnold Jennifer
- Asada Takashi
- Aso Yasuhiro
- Atit Vikram
- Ayala Ricardo
- Badruddoja Michael
- Badzio-jagiello Hanna
- Bajacek Michal
- Barton David
- Bear David
- Benjamin Sabrina
- Bergeron Richard
- Bhatia Perminder
- Black Sandra
- Block Allan
- Bolouri Mohammad
- Bond Wendy
- Bouthillier Jean
- Brangman Sharon
- Brew Bruce
- Brisbin Sarah
- Brisken Toby
- Brodtmann Amy
- Brody Mark
- Brooks Dawn A.
- Brosch Jared
- Brown Celia
- Brownstone Paul
- Bukowczan Sylwia
- Burns Jeffrey
- Cabrera Alicia
- Capote Horace
- Carrasco Angel
- Cevallos Yepez Jose
- Chavez Eric
- Chertkow Howard
- Chyrchel-paszkiewicz Urszula
- Ciabarra Anthony
- Clemmons Edward
- Cohen Daniel
- Cohen Ian
- Cohen Robert
- Collins Emily C.
- Concha Mauricio
- Costell Brian
- Crimmins Denis
- Cruz-pagan Yvette
- Cueli Adolfo
- Cupelo Robert
- Czarnecki Maciej
- Darby David
- Dautzenberg P.l.j.
- De Deyn Peter Paul
- De La Gandara Jose
- Deck Kenneth
- Dibenedetto David
- Dibuono Mark
- Dinnerstein Eric
- Dirican Ahmet
- Dixit Shanker
- Dobryniewski Jacek
- Drake Ryan
- Drysdale Peter
- Duara Ranjan
- Duffy John
- Ellenbogen Aaron
- Evans Cynthia D.
- Faradji Victor
- Feinberg Marc
- Feldman Robert
- Fishman Simon
- Flitman Stephen
- Forchetti Concetta
- Fraga Ivonne
- Frank Andrew
- Frishberg Benjamin
- Fujigasaki
- Fukase Hiroyuki
- Fumero Ileana
- Furihata Kenichi
- Galloway Christopher
- Gandhi Rekha
- George Kristi
- Germain Marcel
- Gitelman Darren
- Goetsch Nicholas
- Goldfarb Danielle
- Goldstein Mark
- Goldstick Lawrence
- Gonzalez Rojas Yaneicy
- Goodman Ira
- Greeley David
- Griffin Carl
- Grigsby Eric
- Grosz Daniel
- Hafner Karl
- Hansson Oskar
- Hart David
- Henein Sam
- Herskowitz Brad
- Higashi Shinji
- Higashi Yasuto
- Ho Gilbert
- Hodgson Jonathan
- Hohenberg Mark
- Hollenbeck Larry
- Holub Richard
- Hori Tomokatsu
- Hort Jakub
- Ilkowski Jan
- Ingram K. Jennifer
- Isaac Mitchell
- Ishikawa Mitsunori
- Janu Lubos
- Johnston Mark
- Julio William
- Justiz William
- Kaga Tomotsugu
- Kakigi Tatsuya
- Kalafer Marvin
- Kamijo Mikiko
- Kaplan Jeffrey
- Karathanos Michael
- Katayama Sadao
- Kaul Siddharth
- Keegan Andrew
- Kerwin Diana
- Khan Arifulla
- Khan Uzma
- Kimura Noriyuki
- Kirk Gregory
- Klodowska Gabriela
- Kowa Hisatomo
- Kutz Christen
- Kwentus Joseph
- Lai Rosalyn
- Lall Ayesha
- Lawrence Mary
- Lee Elly
- Leon Ramon
- Linker Gary
- Lisewski Pawel
- Liss Jonathan
- Liu Collins
- Losk Scott
- Lu Ming
- Lukaszyk Ewelina
- Lynch Jennifer
- Macfarlane Stephen
- Macsweeney Josephine
- Mannering Nicholas
- Markovic Oto
- Marks Donald
- Masdeu Joseph
- Matsui Yutaka
- Matsuishi Kunitaka
- Mcallister Peter
- Mcconnehey Brock
- Mcelveen Alvin
- Mcgill Lora
- Mecca Adam
- Mega Michael
- Mensah Jason
- Mickielewicz Anatol
- Minaeian Artin
- Mintun Mark
- Mocherla Bharat
- Monkul Nery Emel Serap
- Murphy Cynthia
- Murphy Paul
- Nagashima Hirotaka
- Nair Anil
- Nair Malini
- Nardandrea John
- Nash Marshall
- Nasreddine Ziad
- Nishida Yoshihiko
- Norton Jeffrey
- Nunez Lazaro
- O'mahony John
- Ochiai Jun
- Ohkubo Takuya
- Okamura Yasuyuki
- Okorie Eugene
- Olivera Esteban
- Omidvar Omid
- Ortiz-Cruz Desiree
- Osowa Alexander
- Papka Michelle
- Parker Alicia
- Patel Ashok
- Patel Meenakshi
- Patel Paayal
- Patry Claude
- Peckham Elizabeth
- Pfeffer Michael
- Pietras Alison
- Plopper Michael
- Porsteinsson Anton
- Poulin Robitaille Raphael
- Prins Niels
- Puente Orlando
- Ratajczak Marcin
- Rhee Margaret
- Ritchie Craig
- Ritter Angela
- Rodriguez Ables Lilia
- Rodriguez Ramon
- Rojas Julio
- Ross Jeffrey
- Royer Paule
- Rubin Jay
- Russell David
- Rutgers Sterre Malou
- Rutrick Stephanie
- Sadowski Martin
- Safirstein Beth
- Sagisaka Takafumi
- Salloway Stephen
- Scharre Douglas
- Schneider Lon
- Schreiber Curtis
- Schrift Michael
- Schulz Paul
- Schwartz Harvey
- Schwartzbard Julie
- Scott John
- Selem Lissette
- Sethi Pramod
- Sha Sharon
- Sharlin Kenneth
- Sharma Sanjiv
- Shcherbinin Sergey
- Shiovitz Thomas
- Shiwach Rajinder
- Sims John R.
- Skovronsky Daniel M.
- Sladek Martin
- Sloan Bart
- Solomon Paul
- Solomon Paul
- Sorial Ehab
- Sosa Evelio
- Sparks JonDavid
- Stedman Mary
- Steen Susan
- Stein Lee
- Stolyar Arkadiy
- Stoukides John
- Sudoh Shinji
- Sutton James
- Syed Junaid
- Szigeti Kinga
- Tachibana Hisatsugu
- Takahashi Yuichi
- Tateno Amane
- Taylor James Dale
- Taylor Kelly
- Tcheremissine Oleg
- Thebaud Adly
- Thein Stephen
- Thurman Louise
- Toenjes Steven
- Toji Hiromasa
- Toma Misaki
- Tran Duc
- Tsujimoto Masashi
- Turner Raymond
- Uchiyama Akiyoshi
- Ussorowska Dorota
- Vaishnavi Sanjeev
- Valor Elena
- Vandersluis Joel
- Vasquez Alberto
- Velez Juan
- Verghese Cherian
- Vodickova-borzova Klaudia
- Wang Hong
- Watson David
- Weidman David
- Weisman David
- Wessels Alette M.
- White Alexander
- Willingham Katherine
- Winkel Izabela
- Winner Paul
- Winston Jaron
- Wolff Adam
- Yagi Hideo
- Yamamoto Hideki
- Yathiraj Sanjay
- Yoshiyama Yasumasa
- Zboch Marzena
- Zimmer Jennifer A.
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Ofatumumab versus Teriflunomide in Multiple Sclerosis
- Author
- Aaron Carlson
- Achim Berthele
- Adaeze Onuoha
- Adam Wolff
- Adnan Subei
- Agnes Koves
- Ahmad Ata
- Aiden Haghikia
- Aimee Borazanci
- Akram Dastagir
- Albert Saiz Hinarejos
- Alberto Vasquez
- Alena Martinkova
- Alfredo Rodriguez Antigüedad
- Alina Sergeevna Agafina
- Alison Brooke Allen
- Alla Shifrin
- Amit Bar-Or
- Ana Martins Da Silva
- Ana Voldsgaard Jensen
- Andrejs Millers
- Andrew Gale
- Andrew P Keegan
- Andrzej Wiak
- Angel Carrasco
- Angel R Chinea Martinez
- Angela Timoteo
- Angelica Carbajal Ramirez
- Ann Bass
- Anna Naumovna Belova
- Anne Cross
- Annette Okai
- Anselm Kornhuber
- Anshu Rohatgi
- Anton Vladic
- Antonio Uccelli
- Antonio Vasco Salgado
- April Erwin
- Ariel Antezana-Antezana
- Arnfin Bergmann
- Arnon Karni
- Astrid Edland
- Ayse Nur Yuceyar
- Aysun Soysal
- Bar-Or A.
- Barbara Green
- Barbara Willekens
- Bart Van Wijmeersch
- Bartosz Karaszewski
- Beatrijs Wokke
- Belgin Petek Balci
- Ben Turner
- Benedikt Frank
- Bharathy E Sundaram
- Bhupendra Khatri
- Bhupesh Dihenia
- Birte Elias-Hamp
- Bjoern Tackenberg
- Bob W Van Oosten
- Bogdan Gheorghiu
- Bonaventura Casanova Estruch
- Brian Costell
- Brian Steingo
- Brigitte Wildemann
- Bruce L Hughes
- Bruno Brochet
- Carlo Pozzilli
- Carlos Ballario
- Carlos Capela
- Carlos Veira
- Carrie M Hersh
- Cavit Boz
- Celia Oreja-Guevara
- Celine Louapre
- Cesar Castaneda
- Chiara Zecca
- Chris Retief
- Christian Calvo Vildoso
- Christine Lebrun-Frenay
- Christopher Laganke
- Christopher Luzzio
- Cohen J. A.
- Comi G.
- Corey Ford
- Correale J.
- Coyle P. K.
- Craig Edward Herrman
- Craig Senzon
- Cross A. H.
- Csilla Rozsa
- Cynthia Huffman
- Dalia Mickeviciene
- Daniel R Wynn
- David Axel Laplaud
- David Barnes
- David D O Bear
- David H Mattson
- David Lesch
- David Paling
- David Weisman
- de Seze J.
- Deborah A Burke
- Denis Viktorovich Sazonov
- Dennis W Dietrich
- Deren Huang
- Derrick Robertson
- Dheeraj Khurana
- Djamchid Lotfi
- Dmitry Pokhabov
- Don Joseph Alfonso
- Dusan Stefoski
- Edward J Fox
- Egon Kurca
- Ekaterina Igorevna Kairbekova
- Elena Gennadievna Arefieva
- Eli Silber
- Elzbieta Jasinska
- Emily Pharr
- Enrique Alvarez
- Erik Strauss
- Eugen Schlegel
- Eva Meluzinova
- Eva-Maria Maida
- Evanthia Bernitsas
- Faria Amjad
- Farit Axatovich Khabirov
- Filipe Correia
- Florian Then Bergh
- Francesco Sacca
- Francois Emond
- Francois Grandmaison
- Francois Jacques
- Fredrik Piehl
- Fritz Leutmezer
- Gabriel Pardo
- Garry R Cutter
- Gemma Reig Rosello
- Geoffrey Eubank
- Georgi Krastev
- Gerald Mcintosh
- Gereon Nelles
- Giacomo Lus
- Giancarlo Comi
- Giles F Crowell
- Gilles Edan
- Giovanni Castelnovo
- Girolama Alessandra Marfia
- Goodyear A.
- Guntis Karelis
- Guy Laureys
- Halina Bartosik Psujek
- Hana Bokun
- Hans-Peter Hartung
- Haring D. A.
- Hauser S. L.
- Hayrettin Tumani
- Heinz Wiendl
- Helle Hvilsted Nielsen
- Hemanth Rao
- Husnu Efendi
- Igor Antoncic
- Igor Stolyarov
- Igor Vyacheslavovich Litvinenko
- Irina Aleksandrovna Sokolova
- Israel Steiner
- Ivan Milanov
- Ivana Stetkarova
- Ivaylo Tarnev
- Iwona Jastrzebska
- J Michael Hemphill
- Jack H Florin
- Jacqueline Nicholas
- James Napier
- James Overell
- James Scott
- Jan Lycke
- Jan Mares
- Jaroslaw Slawek
- Jason M Silversteen
- Javier Vasallo
- Jean-Raphael Schneider
- Jeanette Wendt
- Jeannette Lechner-Scott
- Jeffrey A Cohen
- Jeffrey Cohen
- Jeffrey Gross
- Jeffrey Groves
- Jeffrey Kaplan
- Jerome de Seze
- Jerry S Wolinsky
- Jessica Stulc
- Jeyaraj Durai Pandian
- Jo Caekebeke
- Joanna A Cooper
- Joao Cerqueira
- Joao De Sa
- John Foley
- John Parratt
- John Scagnelli
- Jolana Markova
- Jolanta Kalnina
- Jonathan C Calkwood
- Jorge Correale
- Jorge Gustavo Jose
- Jose Carlos Alvarez Cermeño
- Jose Martinez Rodriguez
- Jose Meca Lallana
- Jose Pizarro Otero
- Jose Rafecas
- Joshua Katz
- Joy Dev Mukherji
- Juan Antonio Garcia Merino
- Juan Jose Lopez Prieto
- Juha Pekka Eralinna
- Juliette S Saad
- Julio Perez
- Kakarieka A.
- Kappos L.
- Karine Geens
- Karl-Otto Sigel
- Katherine Standley
- Katrin Gross-Paju
- Keith Edwards
- Kenneth Sharlin
- Kerloeguen C.
- Khurram Bashir
- Kimberly Wagner
- Konstantinos Kilidireas
- Konstantinos Voumvourakis
- Kore Liow
- Kristina Svendsen
- Krisztina Kovacs
- Krzysztof Selmaj
- Larisa Ivanovna Volkova
- Larry Lee Blankenship Jr
- Laszlo Mate
- Laszlo Vecsei
- Laura Brambilla
- Lekha Pandit
- Leppert D.
- Li B.
- Liesly Lee
- Liliana Montoya
- Livia De Sousa
- Lluis Ramio Torrenta
- Lon D Lynn
- Lucia Forero Diaz
- Lucienne Costa Frossard Franca
- Ludo Vanopdenbosch
- Ludwig Kappos
- Luis Querol Gutierrez
- Lyubomir Haralanov
- M Mateo Paz Soldan
- Maciej Maciejowski
- Mads Ravnborg
- Marc Debouverie
- Marco Salvetti
- Maria Manova Slavova
- Maria Nikolaevna Zaharova
- Maria Vafaevna Davydovskaya
- Marie Sarah Gagne Brosseau
- Marija Bosnjak Pasic
- Mario Habek
- Marja-Liisa Sumelahti
- Mark Agius
- Mark Allan Goldstein
- Mark Cascione
- Mark Freedman
- Mark Janicki
- Marta Vachova
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- Massimo Filippi
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- Miroslaw Dziki
- Monika Adamczyk Sowa
- Montalban X.
- Murat Terzi
- Nadezhda Alekseevna Malkova
- Natalia Agafonovna Totolyan
- Nathaniel Robb Whaley
- Nikolaos Fakas
- Nikolaos Grigoriadis
- Nikolay Vasilievich Dorogov
- Norma Haydee Deri
- Olaf Martin Hoffmann
- Olivier Deryck
- Ondrej Skoda
- Pahari Ghosh
- Paolo Gallo
- Patricia K Coyle
- Patrick Oschmann
- Patrick Vermersch
- Paul K Winner
- Pavel Hradilek
- Pavle Repovic
- Pedro Serrano Castro
- Penko Shotekov
- Per Soelberg Sørensen
- Peter Koleda
- Peter Turcani
- Peter Valkovic
- Peter Van Domburg
- Peter Vestergaard Rasmussen
- Pierre Clavelou
- Pierre Labauge
- Pingili R.
- Praful Kelkar
- Radi Shahien
- Rafael Arroyo Gonzalez
- Rahul Chakor
- Rahul Kulkarni
- Ramanathan K.
- Randall Trudell
- Raquel Gouveia
- Rasa Kizlaitiene
- Raymond Hupperts
- Reinhard Hohlfeld
- Ricardo Ayala
- Richard Sater
- Robert Bonek
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- Robert Fairborn Armstrong
- Robert Naismith
- Robert Thomas Nahouraii
- Rogier Q Hintzen
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- Ron Milo
- Ronald S Murray
- Roopkumar Gursahani
- Samuel Hunter
- Sangeeta Ravat
- Sara Eichau Madueño
- Sara Qureshi
- Sarah Morrow
- Satori Maria
- Selmaj K.
- Sergio Martinez Yelamos
- Serhan Sevim
- Serkan Ozakbas
- Sharon Lynch
- Sibyl Wray
- Silke Walter
- Silva Butkovic Soldo
- Silvia R Delgado
- Silvia Rossi
- Simona Bonavita
- Somsak Tiamkao
- Srinivasa Rangasetty
- Stacy Donlon
- Stanley Cohan
- Stanya Smith
- Stella Anatolievna Sivertseva
- Stephen C Reingold
- Stephen L Hauser
- Stuart James Shafer
- Sulev Haldre
- Suresh Kumar
- Susan Azalone
- Susan Hibbs
- Susana Liwacki
- Suzanne Hodgkinson
- Sylvia Menck
- Tamara A Miller
- Tamara Castillo Trivino
- Thomas Doerner
- Thomas Giancarlo
- Thy-Sheng Lin
- Till Sprenger
- Tjalf Ziemssen
- Tobias Derfuss
- Tomic D.
- Troy Desai
- Valeria Studer
- Valerie Delvaux
- Varun K Saxena
- Veit Ulrich Becker
- Vera Straeten
- Viera Hancinova
- Vincent Van Pesch
- Virgina Meca Lallana
- Virginia Simnad
- Vladimir Donath
- Vladimira Vuletic
- Waldemar Fryze
- Wiendl H.
- Willi R.
- William David Honeycutt
- William E McElveen
- William Logan
- William Wagner
- Xavier Montalban
- Xaviere Montalban Gairin
- Yves Lapierre
- Zita Biro
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2020
- Field of study
BACKGROUND: Ofatumumab, a subcutaneous anti-CD20 monoclonal antibody, selectively depletes B cells. Teriflunomide, an oral inhibitor of pyrimidine synthesis, reduces T-cell and B-cell activation. The relative effects of these two drugs in patients with multiple sclerosis are not known. METHODS: In two double-blind, double-dummy, phase 3 trials, we randomly assigned patients with relapsing multiple sclerosis to receive subcutaneous ofatumumab (20 mg every 4 weeks after 20-mg loading doses at days 1, 7, and 14) or oral teriflunomide (14 mg daily) for up to 30 months. The primary end point was the annualized relapse rate. Secondary end points included disability worsening confirmed at 3 months or 6 months, disability improvement confirmed at 6 months, the number of gadolinium-enhancing lesions per T1-weighted magnetic resonance imaging (MRI) scan, the annualized rate of new or enlarging lesions on T2-weighted MRI, serum neurofilament light chain levels at month 3, and change in brain volume. RESULTS: Overall, 946 patients were assigned to receive ofatumumab and 936 to receive teriflunomide; the median follow-up was 1.6 years. The annualized relapse rates in the ofatumumab and teriflunomide groups were 0.11 and 0.22, respectively, in trial 1 (difference, -0.11; 95% confidence interval [CI], -0.16 to -0.06; P<0.001) and 0.10 and 0.25 in trial 2 (difference, -0.15; 95% CI, -0.20 to -0.09; P<0.001). In the pooled trials, the percentage of patients with disability worsening confirmed at 3 months was 10.9% with ofatumumab and 15.0% with teriflunomide (hazard ratio, 0.66; P = 0.002); the percentage with disability worsening confirmed at 6 months was 8.1% and 12.0%, respectively (hazard ratio, 0.68; P = 0.01); and the percentage with disability improvement confirmed at 6 months was 11.0% and 8.1% (hazard ratio, 1.35; P = 0.09). The number of gadolinium-enhancing lesions per T1-weighted MRI scan, the annualized rate of lesions on T2-weighted MRI, and serum neurofilament light chain levels, but not the change in brain volume, were in the same direction as the primary end point. Injection-related reactions occurred in 20.2% in the ofatumumab group and in 15.0% in the teriflunomide group (placebo injections). Serious infections occurred in 2.5% and 1.8% of the patients in the respective groups. CONCLUSIONS: Among patients with multiple sclerosis, ofatumumab was associated with lower annualized relapse rates than teriflunomide. (Funded by Novartis; ASCLEPIOS I and II ClinicalTrials.gov numbers, NCT02792218 and NCT02792231.)