162 research outputs found

    Severe Graves' Orbitopathy occurring in a patient with thyroid hemiagenesis

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    Bottom up approach to manage data privacy policy through the front end filter paradigm

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    An increasing number of business services for private companies and citizens are accomplished trough the web and mobile devices. Such a scenario is characterized by high dynamism and untrustworthiness, as a large number of applications exchange different kinds of data. This poses an urgent need for effective means in preserving data privacy. This paper proposes an approach, inspired to the front-end trust filter paradigm, to manage data privacy in a very flexible way. Preliminary experimentation suggests that the solution could be a promising path to follow for web-based transactions which will be very widespread in the next future

    A Data-Driven Slip Estimation Approach for Effective Braking Control under Varying Road Conditions

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    The performances of braking control systems for robotic platforms, e.g., assisted and autonomous vehicles, airplanes and drones, are deeply influenced by the road-tire friction experienced during the maneuver. Therefore, the availability of accurate estimation algorithms is of major importance in the development of advanced control schemes. The focus of this paper is on the estimation problem. In particular, a novel estimation algorithm is proposed, based on a multi-layer neural network. The training is based on a synthetic data set, derived from a widely used friction model. The open loop performances of the proposed algorithm are evaluated in a number of simulated scenarios. Moreover, different control schemes are used to test the closed loop scenario, where the estimated optimal slip is used as the set-point. The experimental results and the comparison with a model based baseline show that the proposed approach can provide an effective best slip estimation

    Forecasting consumer confidence through semantic network analysis of online news

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    This research studies the impact of online news on social and economic consumer perceptions through semantic network analysis. Using over 1.8 million online articles on Italian media covering four years, we calculate the semantic importance of specific economic-related keywords to see if words appearing in the articles could anticipate consumers' judgments about the economic situation and the Consumer Confidence Index. We use an innovative approach to analyze big textual data, combining methods and tools of text mining and social network analysis. Results show a strong predictive power for the judgments about the current households and national situation. Our indicator offers a complementary approach to estimating consumer confidence, lessening the limitations of traditional survey-based methods

    Bottom up approach to manage data privacy policy through the front end filter paradigm

    Get PDF
    An increasing number of business services for private companies and citizens are accomplished trough the web and mobile devices. Such a scenario is characterized by high dynamism and untrustworthiness, as a large number of applications exchange different kinds of data. This poses an urgent need for effective means in preserving data privacy. This paper proposes an approach, inspired to the front-end trust filter paradigm, to manage data privacy in a very flexible way. Preliminary experimentation suggests that the solution could be a promising path to follow for web-based transactions which will be very widespread in the next future

    Visual Localization in the Presence of Appearance Changes Using the Partial Order Kernel

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    Visual localization across seasons and under varying weather and lighting conditions is a challenging task in robotics. In this paper, we present a new sequence-based approach to visual localization using the Partial Order Kernel (POKer), a convolution kernel for string comparison, that is able to handle appearance changes and is robust to speed variations. We use multiple sequence alignment to construct directed acyclic graph representations of the database image sequences, where sequences of images of the same place acquired at different times are represented as alternative paths in a graph. We then use the POKer to compute the pairwise similarities between these graphs and the query image sequences obtained in a subsequent traversal of the environment, and match the corresponding locations. We evaluated our approach on a dataset which features extreme appearance variations due to seasonal changes. The results demonstrate the effectiveness of our approach, where it achieves higher precision and recall than two state-of-the-art baseline method

    Small Molecule Control of Virulence Gene Expression in Francisella tularensis

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    In Francisella tularensis, the SspA protein family members MglA and SspA form a complex that associates with RNA polymerase (RNAP) to positively control the expression of virulence genes critical for the intramacrophage growth and survival of the organism. Although the association of the MglA-SspA complex with RNAP is evidently central to its role in controlling gene expression, the molecular details of how MglA and SspA exert their effects are not known. Here we show that in the live vaccine strain of F. tularensis (LVS), the MglA-SspA complex works in concert with a putative DNA-binding protein we have called PigR, together with the alarmone guanosine tetraphosphate (ppGpp), to regulate the expression of target genes. In particular, we present evidence that MglA, SspA, PigR and ppGpp regulate expression of the same set of genes, and show that mglA, sspA, pigR and ppGpp null mutants exhibit similar intramacrophage growth defects and are strongly attenuated for virulence in mice. We show further that PigR interacts directly with the MglA-SspA complex, suggesting that the central role of the MglA and SspA proteins in the control of virulence gene expression is to serve as a target for a transcription activator. Finally, we present evidence that ppGpp exerts its effects by promoting the interaction between PigR and the RNAP-associated MglA-SspA complex. Through its responsiveness to ppGpp, the contact between PigR and the MglA-SspA complex allows the integration of nutritional cues into the regulatory network governing virulence gene expression

    Crowdsourcing digital health measures to predict Parkinson's disease severity: the Parkinson's Disease Digital Biomarker DREAM Challenge

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    Consumer wearables and sensors are a rich source of data about patients' daily disease and symptom burden, particularly in the case of movement disorders like Parkinson's disease (PD). However, interpreting these complex data into so-called digital biomarkers requires complicated analytical approaches, and validating these biomarkers requires sufficient data and unbiased evaluation methods. Here we describe the use of crowdsourcing to specifically evaluate and benchmark features derived from accelerometer and gyroscope data in two different datasets to predict the presence of PD and severity of three PD symptoms: tremor, dyskinesia, and bradykinesia. Forty teams from around the world submitted features, and achieved drastically improved predictive performance for PD status (best AUROC = 0.87), as well as tremor- (best AUPR = 0.75), dyskinesia- (best AUPR = 0.48) and bradykinesia-severity (best AUPR = 0.95)

    Diagnóstico, tratamento e seguimento do carcinoma medular de tireoide: recomendações do Departamento de Tireoide da Sociedade Brasileira de Endocrinologia e Metabologia

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