Use of Antioxidant Substances in Intestinal Anastomosis in Rats

Introduction: Intestinal anastomosis consist of surgical procedures which there is an anastomotic line between two intestinal segments in order to reconstruct or divert the digestive transit. However, several complications may result from this surgical procedure. Objective: Present, describe and discuss the findings of the literature regarding substances capable of reducing injury and possible complications of intestinal anastomoses. Method: The data were collected by literature review using the descriptors: "intestinal anastomoses", "antioxidants"; and as basis articles published in the published Scientific Electronic Library (Scielo), Lilacs, MedLine and Pubmed databases. Inclusion criteria were original and review articles published in full in the online form in the Portuguese, Spanish and English languages, using the descriptors mentioned above in the respective languages. Results: Scientific articles were collected, in which 38 papers were included in the inclusion criteria. Conclusions: The major parts of substances described in the present study demonstrated be statistically relevant results and the capacity to optimize the anastomotic healing

Avaliação do grau de incapacidade neurofuncional dos pacientes com diagnóstico de Hanseníase/ Assessment of the degree of neurofunctional disability in patients diagnosed with leprosy

Introdução: A hanseníase é uma doença crônica, infectocontagiosa e curável, cujo agente etiológico é o Mycobacterium leprae. A forma de contágio é através do convívio frequente com indivíduo portador sem que este esteja em tratamento. O quadro clínico é caracterizado por manifestações cutâneas e, em casos mais avançados, neurológicas.  Objetivo: Analisar o grau de incapacidade neurofuncional dos pacientes com hanseníase, correlacionando com o tempo de queixas dos sintomas, adesão a poliquimioterapia e ao perfil epidemiológico, em uma unidade de referência em Belém – Pará, no período de 2016-2018. Metodologia: Foi realizado um estudo analítico-observacional, longitudinal do tipo retrospectivo feito em uma unidade de referência no período de 2016-2018. Resultados: Dos 379 pacientes cadastrados na Unidade, 126 totalizam aqueles acometidos pela Hanseníase, ou seja, 33,24% do total. Foram incluídos neste estudo 95 pacientes, sendo 58 (61,1%) do sexo Masculino e 37 (38,9%) do sexo Feminino. A média de idade dos pacientes foi de 53,02 anos, com mínimo de 18 e máximo de 84 anos. Os demais resultados em relação ao grau de incapacidade, às manifestações clínicas, ao tempo de tratamento e ao perfil demográfico estão disponibilizados nas tabelas enumeradas de 1 a 8. Conclusão: Os pacientes com hanseníase em uma unidade de referência em Belém – PA apresentaram um padrão clinico-epidemiológicos de acometimento, cuja faixa etária situa-se entre 53 e 78 anos, com predominância do sexo masculino, de classificação operacional do tipo multibacilar, apresentando reação hansênica tipo I e grau de incapacidade 2 e que buscam atendimento médico em tempo maior de 6 meses

Health-related quality of life in patients with type 1 diabetes mellitus in the different geographical regions of Brazil : data from the Brazilian Type 1 Diabetes Study Group

Background: In type 1 diabetes mellitus (T1DM) management, enhancing health-related quality of life (HRQoL) is as important as good metabolic control and prevention of secondary complications. This study aims to evaluate possible regional differences in HRQoL, demographic features and clinical characteristics of patients with T1DM in Brazil, a country of continental proportions, as well as investigate which variables could influence the HRQoL of these individuals and contribute to these regional disparities. Methods: This was a retrospective, cross-sectional, multicenter study performed by the Brazilian Type 1 Diabetes Study Group (BrazDiab1SG), by analyzing EuroQol scores from 3005 participants with T1DM, in 28 public clinics, among all geographical regions of Brazil. Data on demography, economic status, chronic complications, glycemic control and lipid profile were also collected. Results: We have found that the North-Northeast region presents a higher index in the assessment of the overall health status (EQ-VAS) compared to the Southeast (74.6 ± 30 and 70.4 ± 19, respectively; p < 0.05). In addition, North- Northeast presented a lower frequency of self-reported anxiety-depression compared to all regions of the country (North-Northeast: 1.53 ± 0.6; Southeast: 1.65 ± 0.7; South: 1.72 ± 0.7; Midwest: 1.67 ± 0.7; p < 0.05). These findings could not be entirely explained by the HbA1c levels or the other variables examined. Conclusions: Our study points to the existence of additional factors not yet evaluated that could be determinant in the HRQoL of people with T1DM and contribute to these regional disparities

Health-related quality of life in patients with type 1 diabetes mellitus in the different geographical regions of Brazil : data from the Brazilian Type 1 Diabetes Study Group

Background: In type 1 diabetes mellitus (T1DM) management, enhancing health-related quality of life (HRQoL) is as important as good metabolic control and prevention of secondary complications. This study aims to evaluate possible regional differences in HRQoL, demographic features and clinical characteristics of patients with T1DM in Brazil, a country of continental proportions, as well as investigate which variables could influence the HRQoL of these individuals and contribute to these regional disparities. Methods: This was a retrospective, cross-sectional, multicenter study performed by the Brazilian Type 1 Diabetes Study Group (BrazDiab1SG), by analyzing EuroQol scores from 3005 participants with T1DM, in 28 public clinics, among all geographical regions of Brazil. Data on demography, economic status, chronic complications, glycemic control and lipid profile were also collected. Results: We have found that the North-Northeast region presents a higher index in the assessment of the overall health status (EQ-VAS) compared to the Southeast (74.6 ± 30 and 70.4 ± 19, respectively; p < 0.05). In addition, North- Northeast presented a lower frequency of self-reported anxiety-depression compared to all regions of the country (North-Northeast: 1.53 ± 0.6; Southeast: 1.65 ± 0.7; South: 1.72 ± 0.7; Midwest: 1.67 ± 0.7; p < 0.05). These findings could not be entirely explained by the HbA1c levels or the other variables examined. Conclusions: Our study points to the existence of additional factors not yet evaluated that could be determinant in the HRQoL of people with T1DM and contribute to these regional disparities

Health-related quality of life in patients with type 1 diabetes mellitus in the different geographical regions of Brazil : data from the Brazilian Type 1 Diabetes Study Group

Background: In type 1 diabetes mellitus (T1DM) management, enhancing health-related quality of life (HRQoL) is as important as good metabolic control and prevention of secondary complications. This study aims to evaluate possible regional differences in HRQoL, demographic features and clinical characteristics of patients with T1DM in Brazil, a country of continental proportions, as well as investigate which variables could influence the HRQoL of these individuals and contribute to these regional disparities. Methods: This was a retrospective, cross-sectional, multicenter study performed by the Brazilian Type 1 Diabetes Study Group (BrazDiab1SG), by analyzing EuroQol scores from 3005 participants with T1DM, in 28 public clinics, among all geographical regions of Brazil. Data on demography, economic status, chronic complications, glycemic control and lipid profile were also collected. Results: We have found that the North-Northeast region presents a higher index in the assessment of the overall health status (EQ-VAS) compared to the Southeast (74.6 ± 30 and 70.4 ± 19, respectively; p < 0.05). In addition, North- Northeast presented a lower frequency of self-reported anxiety-depression compared to all regions of the country (North-Northeast: 1.53 ± 0.6; Southeast: 1.65 ± 0.7; South: 1.72 ± 0.7; Midwest: 1.67 ± 0.7; p < 0.05). These findings could not be entirely explained by the HbA1c levels or the other variables examined. Conclusions: Our study points to the existence of additional factors not yet evaluated that could be determinant in the HRQoL of people with T1DM and contribute to these regional disparities