Enfermedad Pulmonar Obstructiva Crónica en Pequeños Animales

Chronic obstructive pulmonary disease (COPD) is a disease of the lower airways, which result in remodelling of the pulmonary tract and culminates with narrowing airway causing progressive obstruction. The disease mainly affects elderly animals and the cause is generally unknown. This review aims to describe the clinical significance, diagnostic tools, main differences between the diagnosis of asthma and bronchitis, as well as therapeutic alternatives that offer better results and fewer side effects for patients.La enfermedad pulmonar obstructiva crónica (EPOC) es una enfermedad de las vías aéreas inferiores, la cual resulta en el remodelado de las vías aéreas y culmina con su estrechamiento provocando obstrucción progresiva. Esta enfermedad afecta principalmente a animales de mediana edad y de edad avanzada y en la mayoría de los casos se desconoce su causa. El presente trabajo de revisión tiene como objetivo mostrar la importancia clínica, las herramientas diagnósticas, las principales diferencias entre el diagnóstico de asma y bronquitis, y las alternativas terapéuticas que ofrecen mejores resultados y menores efectos secundarios para los pacientes

Histomorphological and immunophenotypic diagnoses of gastrointestinal stromal tumors and other sarcomas that affect the intestine of dogs

In view of the morphological similarity between gastrointestinal stromal tumors (GIST) and other sarcomas of the intestine of dogs, the aim was to carry out the histomorphological and immunohistochemical diagnosis of these tumors, associating breed, sex and age, location and tumor invasion. 217 cases were evaluated by histopathology and 36 diagnosed by immunohistochemistry were included (24 GIST and 12 other intestinal sarcomas). Mixed breed dogs were the most diagnosed with GIST, mainly elderly females (9.5±2.2 years); in the other intestinal sarcomas, crossbreeds and Dachshunds, males and females, were equally affected. The cecum was the most affected by GISTs, with tumor invasion of the intestinal layers in all cases. The small intestine was the most affected by the other intestinal sarcomas, with invasion of the layers in most of these tumors. GISTs expressed markers such as CD117 and DOG-1, unlike other intestinal sarcomas. GIST and other intestinal sarcomas denoted histomorphological and immunophenotypic characteristics similar to histopathology, justifying the association of immunohistochemistry for the definitive diagnosis. Keywords: CD117; DOG-1; GIST; veterinary oncolog

Relevance of periodontal disease as a precursor to systemic disorders in companion animals / Relevância da doença periodontal como precursora de afecções sistêmicas em animais de companhia

Periodontal disease (periodontitis) is an oral condition characterized by the involvement of the periodontium, that is, structures that protect and support the teeth. It is commonly diagnosed in small animals, especially in the elderly, and is a frequent cause of tooth loss in both dogs and cats. The etiological factor of periodontal disease is the organized sub- and supragingival plaque and numerous factors are responsible for the predisposition of the disease such as age, race, size and immunity of the patient. The symptomatology of the affected animals varies according to the degree of involvement of the disease, but they usually include halitosis, hyperemia, bleeding and gingival retraction, odontoliths, contact gingival ulcers, furcation exposure and tooth loss. The diagnosis is based on history, complete anamnesis, thorough examination of the oral cavity associated with extra and intraoral x-rays. The periodontal treatment has the purpose of eliminating the causal agent, removing dental stones, tooth extractions and polishing the remaining dental elements. In addition to local changes, periodontal disease can cause systemic damage, due to the rich vascularization of the periodontium and tooth movement in the tooth socket, allowing bacteria and their metabolites to enter the lymphatic and blood vessels during patient chewing, causing organ failure. In view of the high incidence of periodontal disease in pets and the consequent local and systemic changes, the objective of the current work was to carry out a bibliographic survey on this oral condition in dogs and cats, highlighting the damage to other organs due to bacteremia. In this context, the scientific literature emphasizes that the systemic immune response secondary to bacteremia predisposes the formation of immune complexes in the bloodstream that adhere to the walls of the endothelium causing local inflammation and endothelial lysis of the heart, kidneys, liver, lungs, bones, among others, reflecting on diverse symptomatology. Thus, it is assumed that early diagnosis and treatment of periodontal disease can prevent the establishment and local progression of oral disease and, consequently, systemic impairments that directly affect the quality of life and survival of the affected.Periodontal disease (periodontitis) is an oral condition characterized by the involvement of the periodontium, that is, structures that protect and support the teeth. It is commonly diagnosed in small animals, especially in the elderly, and is a frequent cause of tooth loss in both dogs and cats. The etiological factor of periodontal disease is the organized sub- and supragingival plaque and numerous factors are responsible for the predisposition of the disease such as age, race, size and immunity of the patient. The symptomatology of the affected animals varies according to the degree of involvement of the disease, but they usually include halitosis, hyperemia, bleeding and gingival retraction, odontoliths, contact gingival ulcers, furcation exposure and tooth loss. The diagnosis is based on history, complete anamnesis, thorough examination of the oral cavity associated with extra and intraoral x-rays. The periodontal treatment has the purpose of eliminating the causal agent, removing dental stones, tooth extractions and polishing the remaining dental elements. In addition to local changes, periodontal disease can cause systemic damage, due to the rich vascularization of the periodontium and tooth movement in the tooth socket, allowing bacteria and their metabolites to enter the lymphatic and blood vessels during patient chewing, causing organ failure. In view of the high incidence of periodontal disease in pets and the consequent local and systemic changes, the objective of the current work was to carry out a bibliographic survey on this oral condition in dogs and cats, highlighting the damage to other organs due to bacteremia. In this context, the scientific literature emphasizes that the systemic immune response secondary to bacteremia predisposes the formation of immune complexes in the bloodstream that adhere to the walls of the endothelium causing local inflammation and endothelial lysis of the heart, kidneys, liver, lungs, bones, among others, reflecting on diverse symptomatology. Thus, it is assumed that early diagnosis and treatment of periodontal disease can prevent the establishment and local progression of oral disease and, consequently, systemic impairments that directly affect the quality of life and survival of the affected.