Development and Evaluation of a Disease Large Animal Model for Preclinical Assessment of Renal Denervation Therapies

[EN] New-generation catheters-based renal denervation (RDN) is under investigation for the treatment of uncontrolled hypertension (HTN). We assessed the feasibility of a large animal model of HTN to accommodate the human RDN devices. Ten minipigs were instrumented to measure blood pressure (BP) in an awake-state. HTN was induced with subcutaneous 11-deoxycorticosterone (DOCA, 100 mg/kg) implants. Five months after, the surviving animals underwent RDN with the Symplicity® system. Norepinephrine (NE) renal gradients were determined before and 1 month after RDN. Renal arteries were processed for histological (hematoxylin-eosin, Movat pentachrome) and immunohistochemical (S100, tyrosine-hydroxylase) analyses. BP significantly rose after DOCA implants. Six animals died prematurely, mainly from infectious causes. The surviving animals showed stable BP levels after 5 months. One month after RDN, nerve damage was showed in three animals, with impedance drop >10%, NE gradient drop and reduction in BP. The fourth animal showed no nerve damage, impedance drop <10%, NE gradient increase and no change in BP. In conclusion, the minipig model of DOCA-induced HTN is feasible, showing durable effects. High mortality should be addressed in next iterations of this model. RDN may partially offset the DOCA-induced HTN. Impedance drop and NE renal gradient could be markers of RDN success.SIThis research was funded by Consejería de Salud, Junta de Castilla and Leon, Spain, the Grant GRS 1001/A/2014.We want to thank Medtronic Iberia for the donation of the Symplicity catheters used in this experiment

Discutindo a educação ambiental no cotidiano escolar: desenvolvimento de projetos na escola formação inicial e continuada de professores

A presente pesquisa buscou discutir como a Educação Ambiental (EA) vem sendo trabalhada, no Ensino Fundamental e como os docentes desta escola compreendem e vem inserindo a EA no cotidiano escolar., em uma escola estadual do município de Tangará da Serra/MT, Brasil. Para tanto, realizou-se entrevistas com os professores que fazem parte de um projeto interdisciplinar de EA na escola pesquisada. Verificou-se que o projeto da escola não vem conseguindo alcançar os objetivos propostos por: desconhecimento do mesmo, pelos professores; formação deficiente dos professores, não entendimento da EA como processo de ensino-aprendizagem, falta de recursos didáticos, planejamento inadequado das atividades. A partir dessa constatação, procurou-se debater a impossibilidade de tratar do tema fora do trabalho interdisciplinar, bem como, e principalmente, a importância de um estudo mais aprofundado de EA, vinculando teoria e prática, tanto na formação docente, como em projetos escolares, a fim de fugir do tradicional vínculo “EA e ecologia, lixo e horta”.Facultad de Humanidades y Ciencias de la Educació

Measurement of the Drell-Yan Cross Section in pp Collisions at s\sqrt{s} = 7 TeV

The Drell-Yan differential cross section is measured in pp collisions at sqrt(s) = 7 TeV, from a data sample collected with the CMS detector at the LHC, corresponding to an integrated luminosity of 36 inverse picobarns. The cross section measurement, normalized to the measured cross section in the Z region, is reported for both the dimuon and dielectron channels in the dilepton invariant mass range 15-600 GeV. The normalized cross section values are quoted both in the full phase space and within the detector acceptance. The effect of final state radiation is also identified. The results are found to agree with theoretical predictions.The Drell-Yan differential cross section is measured in pp collisions at sqrt(s) = 7 TeV, from a data sample collected with the CMS detector at the LHC, corresponding to an integrated luminosity of 36 inverse picobarns. The cross section measurement, normalized to the measured cross section in the Z region, is reported for both the dimuon and dielectron channels in the dilepton invariant mass range 15-600 GeV. The normalized cross section values are quoted both in the full phase space and within the detector acceptance. The effect of final state radiation is also identified. The results are found to agree with theoretical predictions

Measurement of the inclusive W and Z production cross sections in pp collisions at s√=7 TeV with the CMS experiment

A measurement of inclusive W and Z production cross sections in pp collisions at sqrt(s)=7 TeV is presented. The electron and muon decay channels are analyzed in a data sample collected with the CMS detector at the LHC and corresponding to an integrated luminosity of 36 inverse picobarns. The measured inclusive cross sections are sigma(pp-> WX) B(W-> l nu) = 10.30 +/- 0.02 (stat.) +/- 0.10 (syst.) +/- 0.10 (th.) +/- 0.41 (lumi.) nb and sigma(pp -> ZX) B(Z-> l^+l^-) = 0.974 +/- 0.007 (stat.) +/- 0.007 (syst.) +/- 0.018 (th.) +/- 0.039 (lumi.) nb, limited to the dilepton invariant mass range 60 to 120 GeV. The luminosity-independent cross section ratios are [sigma(pp->WX) B(W-> l nu)]/[sigma(pp-> ZX) B(Z->l^+l^-)] = 10.54 +/- 0.07 (stat.) +/- 0.08 (syst.) +/- 0.16 (th.) and [sigma(pp->W^+X) B(W^+ -> l^+nu)] / [sigma(pp->W^- X) +B(W^- -> l^- nu)] = 1.421 +/- 0.006 (stat.) +/- 0.014 (syst.) +/- 0.029 (th.). -> The measured values agree with next-to-next-to-leading order QCD cross section calculations based on recent parton distribution functions.A measurement of inclusive W and Z production cross sections in pp collisions at sqrt(s)=7 TeV is presented. The electron and muon decay channels are analyzed in a data sample collected with the CMS detector at the LHC and corresponding to an integrated luminosity of 36 inverse picobarns. The measured inclusive cross sections are sigma(pp-> WX) B(W-> l nu) = 10.30 +/- 0.02 (stat.) +/- 0.10 (syst.) +/- 0.10 (th.) +/- 0.41 (lumi.) nb and sigma(pp -> ZX) B(Z-> l^+l^-) = 0.974 +/- 0.007 (stat.) +/- 0.007 (syst.) +/- 0.018 (th.) +/- 0.039 (lumi.) nb, limited to the dilepton invariant mass range 60 to 120 GeV. The luminosity-independent cross section ratios are [sigma(pp->WX) B(W-> l nu)]/[sigma(pp-> ZX) B(Z->l^+l^-)] = 10.54 +/- 0.07 (stat.) +/- 0.08 (syst.) +/- 0.16 (th.) and [sigma(pp->W^+X) B(W^+ -> l^+nu)] / [sigma(pp->W^- X) B(W^- -> l^- nu)] = 1.421 +/- 0.006 (stat.) +/- 0.014 (syst.) +/- 0.029 (th.). The measured values agree with next-to-next-to-leading order QCD cross section calculations based on recent parton distribution functions

Search for Same-Sign Top-Quark Pair Production at sqrt(s) = 7 TeV and Limits on Flavour Changing Neutral Currents in the Top Sector

An inclusive search for same-sign top-quark pair production in pp collisions at sqrt(s) = 7 TeV is performed using a data sample recorded with the CMS detector in 2010, corresponding to an integrated luminosity of 35 inverse picobarns. This analysis is motivated by recent studies of p p-bar to t t-bar reporting mass-dependent forward-backward asymmetries larger than expected from the standard model. These asymmetries could be due to Flavor Changing Neutral Currents (FCNC) in the top sector induced by t-channel exchange of a massive neutral vector boson (Z'). Models with such a Z' also predict enhancement of same-sign top-pair production in pp or p p-bar collisions. Limits are set as a function of the Z'mass and its couplings to u and t quarks. These limits disfavour the FCNC interpretation of the Tevatron results.An inclusive search for same-sign top-quark pair production in pp collisions at sqrt(s) = 7 TeV is performed using a data sample recorded with the CMS detector in 2010, corresponding to an integrated luminosity of 35 inverse picobarns. This analysis is motivated by recent studies of p p-bar to t t-bar reporting mass-dependent forward-backward asymmetries larger than expected from the standard model. These asymmetries could be due to Flavor Changing Neutral Currents (FCNC) in the top sector induced by t-channel exchange of a massive neutral vector boson (Z'). Models with such a Z' also predict enhancement of same-sign top-pair production in pp or p p-bar collisions. Limits are set as a function of the Z'mass and its couplings to u and t quarks. These limits disfavour the FCNC interpretation of the Tevatron results.An inclusive search for same-sign top-quark pair production in pp collisions at sqrt(s) = 7 TeV is performed using a data sample recorded with the CMS detector in 2010, corresponding to an integrated luminosity of 35 inverse picobarns. This analysis is motivated by recent studies of p p-bar to t t-bar reporting mass-dependent forward-backward asymmetries larger than expected from the standard model. These asymmetries could be due to Flavor Changing Neutral Currents (FCNC) in the top sector induced by t-channel exchange of a massive neutral vector boson (Z'). Models with such a Z' also predict enhancement of same-sign top-pair production in pp or p p-bar collisions. Limits are set as a function of the Z'mass and its couplings to u and t quarks. These limits disfavour the FCNC interpretation of the Tevatron results

J/ψ\psi and ψ\psi(2S) production in pp collisions at s\sqrt{s} = 7 TeV

A measurement of the J/$\psi$ and psi(2S) production cross sections in pp collisions at $\sqrt{s}$=7 TeV with the CMS experiment at the LHC is presented. The data sample corresponds to an integrated luminosity of 37 inverse picobarns. Using a fit to the invariant mass and decay length distributions, production cross sections have been measured separately for prompt and non-prompt charmonium states, as a function of the meson transverse momentum in several rapidity ranges. In addition, cross sections restricted to the acceptance of the CMS detector are given, which are not affected by the polarization of the charmonium states. The ratio of the differential production cross sections of the two states, where systematic uncertainties largely cancel, is also determined. The branching fraction of the inclusive B to psi(2S) X decay is extracted from the ratio of the non-prompt cross sections to be: $BR(B \to \psi(2S) X) = (3.08 \pm 0.12(stat.+syst.) \pm 0.13(theor.) \pm 0.42(BR_{PDG}))\times 10^{-3}$.A measurement of the J/psi and psi(2S) production cross sections in pp collisions at sqrt(s)=7 TeV with the CMS experiment at the LHC is presented. The data sample corresponds to an integrated luminosity of 37 inverse picobarns. Using a fit to the invariant mass and decay length distributions, production cross sections have been measured separately for prompt and non-prompt charmonium states, as a function of the meson transverse momentum in several rapidity ranges. In addition, cross sections restricted to the acceptance of the CMS detector are given, which are not affected by the polarization of the charmonium states. The ratio of the differential production cross sections of the two states, where systematic uncertainties largely cancel, is also determined. The branching fraction of the inclusive B to psi(2S) X decay is extracted from the ratio of the non-prompt cross sections to be: BR(B to psi(2S) X) = (3.08 +/- 0.12(stat.+syst.) +/- 0.13(theor.) +/- 0.42(BR[PDG])) 10^-