Los efectos de una intervención preventiva breve en ciberacoso y grooming en adolescentes

El desarrollo de intervenciones breves y económicas que reduzcan las conductas de riesgo en la adolescencia constituye un desafío para la investigación actual. Este estudio aborda la prevención de dos problemas de comportamiento online en adolescentes (ciberacoso y grooming en Internet). Dos estudios piloto evaluaron los efectos de una intervención de una hora que combinó autoafirmaciones (AA) con la teoría incremental de la personalidad (TIP) en el ciberacoso y el grooming. En el estudio 1 participaron 339 adolescentes (51% chicos, edad media = 14.12 años, DT = 0.70), que fueron asignados aleatoriamente a la intervención AA + TIP o una de dos condiciones de control. Los análisis de regresión jerárquica indicaron que la intervención AA + TIP redujo la reciprocidad entre la solicitud sexual y la interacción sexualizada con adultos, así como entre la victimización y la perpetración de ciberacoso. El estudio 2 incluyó a 214 adolescentes (50.3% chicos, edad media = 14.06 años, DT = 0.96), que fueron asignados aleatoriamente a AA + TIP o a una condición de control. Los análisis de modelos lineales jerárquicos indicaron que AA + TIP redujo la reciprocidad entre la solicitud sexual y la interacción sexualizada con adultos y redujo la perpetración de ciberacoso. Los estudios aportaron evidencia preliminar de las ventajas de la intervención AA + TIP.The development of brief and inexpensive interventions that reduce risky behaviors in adolescence constitute a challenge for current research. This study addresses the prevention of two online behavior problems in adolescents (cyberbullying and online grooming). Two pilot studies evaluated the effects of a 1-hour intervention, which combined self-affirmation (SA) with the incremental theory of personality (ITP), for cyberbullying and online grooming. Study 1 involved 339 adolescents (51% male, mean age = 14.12 years, SD = 0.70), who were randomly assigned to the SA + ITP intervention or one of two control conditions. Hierarchical regression analyses indicated that the SA + ITP intervention reduced the reciprocity between sexual solicitation and sexualized interaction with adults, as well as between cyberbullying victimization and perpetration. Study 2 included 214 adolescents (50.3% male, mean age = 14.06 years, SD = 0.96), who were randomly assigned to the SA + ITP or a control condition. Hierarchical linear modeling analyses indicated that the SA + ITP reduced the reciprocity between sexual solicitation and sexualized interaction with adults, and reduced cyberbullying perpetration. The studies provided preliminary evidence of the benefits of the SA + ITP intervention.This research was supported by a grant from the Fundación BBVA (Banco Bilbao Vizcaya Argentaria) (Ref.PR[18]_SOC_0096) and from the Basque Country (Ref. IT982-16)

Spatial intratumoural heterogeneity in the expression of GIT1 is associated with poor prognostic outcome in oestrogen receptor positive breast cancer patients with synchronous lymph node metastases [version 2; referees: 2 approved]

Background: The outcome for oestrogen receptor positive (ER+) breast cancer patients has improved greatly in recent years largely due to targeted therapy. However, the presence of involved multiple synchronous lymph nodes remains associated with a poor outcome. Consequently, these patients would benefit from the identification of new prognostic biomarkers and therapeutic targets. The expression of G-protein-coupled receptor kinase-interacting protein 1 (GIT1) has recently been shown to be an indicator of advanced stage breast cancer. Therefore, we investigated its expression and prognostic value of GIT1 in a cohort of 140 ER+ breast cancer with synchronous lymph node involvement. Methods: Immunohistochemistry was employed to assess GIT1 expression in a tissue microarray (TMA) containing duplicate non-adjacent cores with matched primary tumour and lymph node tissue (n=140). GIT1 expression in tumour cells was scored and statistical correlation analyses were carried out. Results: The results revealed a sub-group of patients that displayed discordant expression of GIT1 between the primary tumour and the lymph nodes (i.e. spatial intratumoural heterogeneity). We observed that loss of GIT1 expression in the tumour cells of the metastasis was associated with a shorter time to recurrence, poorer overall survival, and a shorter median survival time. Moreover, multivariate analysis demonstrated that GIT1 expression was an independent prognostic indicator. Conclusions: GIT1 expression enabled the identification of a sub-class of ER+ patients with lymph node metastasis that have a particularly poor prognostic outcome. We propose that this biomarker could be used to further stratify ER+ breast cancer patients with synchronous lymph node involvement and therefore facilitate adjuvant therapy decision making