2 research outputs found
Development of germ cell neoplasia in situ in chinchilla rabbits
The present study was designed to describe
the development of germ cell neoplasia in situ in
Chinchilla rabbit by administration of estradiol. The
study was performed in rabbits distributed into two
groups: control and 17 β-estradiol. The determination of
histological alterations and POU5F1 and c-kit proteins
employed as biomarkers for the diagnosis of this
neoplasia was carried out. Testicular descent and
complete spermatogenesis were observed in the control
group. The protein biomarkers were negative. However,
in the rabbits treated with estradiol, the testes remained
undescended with the gonocytes undifferentiated to
spermatogonia. There were histological lesions owing to
germ cell neoplasia in situ and positive to POU5F1 and
c-kit proteins. These findings indicate that the chinchilla
rabbit is an ideal model to study this neoplasia in which
the histological characteristics and biomarkers of the
disease could be clearly observed. Using this model we
suggested that the persisting gonocytes could be
responsible for the development of germ cell neoplasia
in situ