Peranan Guru dalam Meningkatkan Keaktifan Peserta Didik Melalui Media Audio Visual Pada Mata Pelajaran PPKN di Kelas XI SMK Negeri 2 Penyabungan Tahun Ajaran 2022/2023

This study aims to examine the teacher's role as educator, facilitator, and motivator in increasing student activity through audio-visual media in Civics subjects in Class XI SMK Negeri 2 Penyabungan in the 2022/2023 academic year. This research was conducted at SMK Negeri 2 Penyabung, and used Civics teachers as resource persons to support data acquisition in this study. This research was conducted from February to the second week of March 2023. Data collection was carried out through gathering information by observing and checking into the classroom when the teacher was teaching using audio-visual media and then adding in-depth questions to further strengthen the results of the research data. From this study it was found that the role of the teacher as an educator in increasing the activity of students through Audio Visual learning media in PKn subjects at SMK Negeri 2 Panyabungan was carried out by providing a fair attitude for students in using audio visual media and having a strong mentality in dealing with participants. students who are taught, have extensive knowledge in educating students properly, and always provide good examples or examples to students in using learning media in the classroom; The role of the teacher as a facilitator in increasing the activity of students through learning media in Civics subjects at SMK Negeri 2 Penyabung, namely by providing audio-visual media that can attract the attention of students so that students' interest in learning becomes higher, and the role of the teacher as a motivator in increasing the activeness of students through learning media in Civics subjects at SMK Negeri 2 Panyabungan, namely the teacher always provides direction and encouragement so that students' interest in learning in using audio-visual media becomes more effective

Persepsi Masyarakat Islam terhadap Agama Kristen (Study Deskriptif Di Labuhan Ruku Kecamatan Talawi Kabupaten Batub Bara)

This research is entitled Perceptions of Islamic Communities towards Christianity in Labuhan Ruku, Talawi Sub-District, Batu Bara District. In this research, the writer wanted to find out how the relationship between Islamic society and Christian society was, whether it was peaceful and peaceful or whether there was conflict in it. This study aims to examine the religious life of the community in Labuhan Ruku and also to examine the perceptions of Muslims in Labuhan Ruku towards Christians and to examine the impact of this perception on religious life. The research method used in this study is a qualitative research method with a descriptive approach, namely by conducting interviews with the Islamic community living in Labuhan Ruku. This research was conducted in December 2022. Based on the results of the research conducted, it can be concluded that not everything is true, if Muslims and Christians cannot live together without conflict, because in Labuhan Ruku Muslims and Christians can live side by side in peace, harmony and mutual tolerance. Muslims do not regard Christians as enemies and vice versa, problems that occur outside their area such as conflicts between religions do not affect the harmonious relationship between them. If we want to improve relations between Christians and Muslims we must deepen our knowledge. We have to avoid stereotypes, we have to learn more about other religions so that we understand how their lives are and how we can respect each other so that we can coexist together in peace and tranquilit

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

Background: Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19. Methods: This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. The trial is underway at 177 NHS hospitals from across the UK. Eligible and consenting patients were randomly assigned (1:1) to receive either usual care alone (usual care group) or usual care plus high-titre convalescent plasma (convalescent plasma group). The primary outcome was 28-day mortality, analysed on an intention-to-treat basis. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936. Findings: Between May 28, 2020, and Jan 15, 2021, 11558 (71%) of 16287 patients enrolled in RECOVERY were eligible to receive convalescent plasma and were assigned to either the convalescent plasma group or the usual care group. There was no significant difference in 28-day mortality between the two groups: 1399 (24%) of 5795 patients in the convalescent plasma group and 1408 (24%) of 5763 patients in the usual care group died within 28 days (rate ratio 1·00, 95% CI 0·93–1·07; p=0·95). The 28-day mortality rate ratio was similar in all prespecified subgroups of patients, including in those patients without detectable SARS-CoV-2 antibodies at randomisation. Allocation to convalescent plasma had no significant effect on the proportion of patients discharged from hospital within 28 days (3832 [66%] patients in the convalescent plasma group vs 3822 [66%] patients in the usual care group; rate ratio 0·99, 95% CI 0·94–1·03; p=0·57). Among those not on invasive mechanical ventilation at randomisation, there was no significant difference in the proportion of patients meeting the composite endpoint of progression to invasive mechanical ventilation or death (1568 [29%] of 5493 patients in the convalescent plasma group vs 1568 [29%] of 5448 patients in the usual care group; rate ratio 0·99, 95% CI 0·93–1·05; p=0·79). Interpretation: In patients hospitalised with COVID-19, high-titre convalescent plasma did not improve survival or other prespecified clinical outcomes. Funding: UK Research and Innovation (Medical Research Council) and National Institute of Health Research

Epithelial-interleukin-1 inhibits collagen formation by airway fibroblasts: Implications for asthma

In asthma, the airway epithelium has an impaired capacity to differentiate and plays a key role in the development of airway inflammation and remodeling through mediator release. The study objective was to investigate the release of (IL)-1 family members from primary airway epithelial-cells during differentiation, and how they affect primary airway fibroblast (PAF)-induced inflammation, extracellular matrix (ECM) production, and collagen I remodeling. The release of IL-1α/β and IL-33 during airway epithelial differentiation was assessed over 20-days using air-liquid interface cultures. The effect of IL-1 family cytokines on airway fibroblasts grown on collagen-coate