Orbits and masses in the young triple system TWA 5

We aim to improve the orbital elements and determine the individual masses of the components in the triple system TWA 5. Five new relative astrometric positions in the H band were recorded with the adaptive optics system at the Very Large Telescope (VLT). We combine them with data from the literature and a measurement in the Ks band. We derive an improved fit for the orbit of TWA 5Aa-b around each other. Furthermore, we use the third component, TWA 5B, as an astrometric reference to determine the motion of Aa and Ab around their center of mass and compute their mass ratio. We find an orbital period of 6.03+/-0.01 years and a semi-major axis of 63.7+/-0.2 mas (3.2+/-0.1 AU). With the trigonometric distance of 50.1+/-1.8 pc, this yields a system mass of 0.9+/-0.1 Msun, where the error is dominated by the error of the distance. The dynamical mass agrees with the system mass predicted by a number of theoretical models if we assume that TWA5 is at the young end of the age range of the TW Hydrae association. We find a mass ratio of M_Ab / M_Aa = 1.3 +0.6/-0.4, where the less luminous component Ab is more massive. This result is likely to be a consequence of the large uncertainties due to the limited orbital coverage of the observations.Comment: 9 pages, 8 figures, accepted by Astronomy and Astrophysic

Kounis Syndrome Associated With Selective Anaphylaxis to Cefazolin.

info:eu-repo/semantics/publishedVersio

Thickness-dependent electrocaloric effect in mixed-phase Pb0.87Ba0.1 La0.02 (Zr0.6Sn0.33Ti0.07) O3 thin films

Full-perovskite Pb0.87Ba0.1La0.02(Zr0.6Sn0.33Ti0.07)O3 (PBLZST) thin films were fabricated by a sol–gel method. These revealed both rhombohedral and tetragonal phases, as opposed to the full-tetragonal phase previously reported in ceramics. The fractions of tetragonal and rhombohedral phases are found to be strongly dependent on film thickness. The fraction of tetragonal grains increases with increasing film thickness, as the substrate constraint throughout the film decreases with film thickness. The maximum of the dielectric constant (εm) and the corresponding temperature (Tm) are thickness-dependent and dictated by the fraction of rhombohedral and tetragonal phase, with εm reaching a minimum at 400 nm and Tm shifting to higher temperature with increasing thickness. With the thickness increase, the breakdown field decreases, but field-induced antiferroelectric–ferroelectric (EAFE−FE) and ferroelectric–antiferroelectric (EFE−AFE) switch fields increase. The electrocaloric effect increases with increasing film thickness

A investigação adequada e ética sobre nutrição é um direito humano

Editorial Dr. Maria Isabel T. D. Correi

Hermitian Yang-Mills instantons on resolutions of Calabi-Yau cones

We study the construction of Hermitian Yang-Mills instantons over resolutions of Calabi-Yau cones of arbitrary dimension. In particular, in d complex dimensions, we present an infinite family, parametrised by an integer k and a continuous modulus, of SU(d) instantons. A detailed study of their properties, including the computation of the instanton numbers is provided. We also explain how they can be used in the construction of heterotic non-Kahler compactifications.Comment: 20 pages, 1 figure; typos corrected, section 3.1 expande

Are Stroke Occurrence and Outcome Related to Weather Parameters? Results from a Population-Based Study in Northern Portugal

Background: Changes in meteorological parameters have been associated with cardiovascular mortality and stroke. The high incidence of stroke in Portugal may be modelled by short- or long-term weather changes whose effect may be different across stroke types and severity. Methods: Data include all patients with a first-ever-in-a-lifetime stroke registered in a population of 86,023 residents in the city of Porto from October 1998 to September 2000. Specific stroke types were considered and ischaemic stroke (IS) subtype was defined according to the Oxfordshire Community Stroke Projet classification and the Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria. Information on daily temperature, humidity and air pressure was obtained from the National Meteorological Office. The Poisson distribution was used to model the daily number of events as a function of each weather parameter measured over different hazard periods, and the binomial model to contrast effects across subgroups. Differential effects of meteorological parameters and hazard periods upon stroke occurrence and outcome were analysed in a stepwise model. Results: Among the 462 patients registered, 19.6% had a primary intracerebral haemorrhage (PICH) and 75.3% an IS. Among patients with IS, 21.6% were total anterior circulation infarcts (TACIs), 19.8% partial anterior circulation infarcts (PACIs), 19.5% posterior circulation infarcts (POCIs) and 39.1% were lacunar infarcts (LACIs). The aetiology of IS was large artery atherosclerosis in 6.9%, cardioembolism in 23.3% and small artery occlusion in 35.6%. The incidence of PICH increased by 11.8% (95% CI: 3.8–20.4%) for each degree drop in the diurnal temperature range in the preceding day. The incidence of IS increased by 3.9% (95% CI: 1.6–6.3%) and cardioembolic IS by 5.0% (95% CI: 0.2–10.1%) for a 1 ° C drop in minimum temperature in the same hazard period. The incidence of TACIs followed the IS pattern while for PACIs and POCIs there were stronger effects of longer hazard periods and no association was found for LACIs. The relative risk of a fatal versus a non-fatal stroke increased by 15.5% (95% CI: 6.1–25.4%) for a 1 ° C drop in maximum temperature over the previous day. Conclusions: Outdoor temperature and related meteorological parameters are associated with stroke occurrence and severity. The different hazard periods for temperature effects and the absence of association with LACIs may explain the heterogeneous effects of weather on stroke occurrence found in community- based and hospital admission studies. Emergency services should be aware that specific weather conditions are more likely to prompt calls for more severe strokes

Assignment of novel functions to Helicobacter pylori 26695’s genome and reconstruction of a genome-scale metabolic model

Helicobacter pylori is a pathogenic organism associated with human gastric diseases. The development of mathematical models of metabolism is now considered a fundamental part of the study of the cell. For the particular case of microorganisms associated with human diseases, information on metabolic and regulatory networks can be used to understand the molecular factors of the microorganism that are likely to interact with the host and cause diseases. The availability of the genome sequence of H. pylori 26695 and its annotation has allowed in the past the construction of a metabolic model for this organism. The first genome-scale metabolic model for H. pylori 26695 was published in 2002 (iCS291) and a corrected reconstruction was published in 2005 (iIT341 GSM/GPR). The main goal of the present work was to update H. pylori’s genome-scale metabolic model based on the new information made available. For that purposes, using new annotation methodologies and data available in databases, an assignment of novel functions to H. pylori 26695’s genome was performed. For a total of 510 “hypothetical proteins” (almost 1/3 of the genes) identified in the last re-annotation, 137 new functions were attributed. A total of 581 E.C. numbers were assigned to CDS, being 528 complete E.C. numbers. This new information was used as the basis of the model reconstruction. In addition, transport reactions in the model were updated. The biomass equation was reviewed and H. pylori biomass coefficients and composition were adjusted. The obtained model successfully predicted the nutritional requirements and amino acids essentialities, which were experimentally validated. As a result, the present work presents a new H. pylori 26695 genome-scale metabolic model with more accurate and reliable predictions and can be used to identify potential targets for designing more effective drugs for H. pylori inactivation

Assignment of novel functions to Helicobacter pylori 26695’s genome

Helicobacter pylori is a pathogenic bacterium that colonizes the human epithelia, causing duodenal and gastric ulcers as well as gastric cancer. The genome of H. pylori 26695 has been sequenced and annotated. In addition, two genome-scale metabolic models have been developed. In order to maintain accurate and relevant information on coding sequences (CDS) and to retrieve new information, the assignment of new functions to Helicobacter pylori 26695’s genes was performed. The use of software tools, on-line databases and an annotation pipeline for inspecting each gene allowed the attribution of validated E.C. numbers to metabolic genes, and the assignment of 177 new functions to the CDS of this bacterium. This information provides relevant biological information for the scientific community dealing with this organism and can be used as the basis for a new metabolic model reconstruction.(undefined

Siza ATLAS: Filling the gaps for world heritage

Following the ICOMOS study “The World Heritage list: filling the gaps – an action plan for the future” and the Global Strategy of the UNESCO World Heritage Committee (WHC) encouraging State Parties to submit nominations on the 20th century Heritage, ICOMOS-Portugal presented an Ensemble of works of Álvaro Siza for the World Heritage (WH) Tentative List, in 2017. Despite the international recognition of Álvaro Siza’s architecture, there is not yet a complete and systematic inventory of his built works. The information on his work is scattered, partial or incomplete. The existent literature focuses more on compositional issues of the design, and less on the constructive and technical dimension of his works, on the state of conservation of the buildings, or on possible threats affecting them. In this framework, the scope of SizaATLAS project is to address a comprehensive inventory of all of Siza’s built works, and to develop a detailed documentation and analysis of the 18 buildings selected for the WH List. This research and the comparison with the oeuvre of other architects will result in a better understanding of the unique value of Siza’s architecture, in a national and international context. This will be key to establish the justification of the Oustanding Universal Value (OUV) of his work, its national protection and an effective management system to support the instruction of Siza’s works nomination for the WH List. The research intends to develop: 1) a COLLABORATIVE PLATFORM for open access, which will allow database management and exchange, as well as forms’ compilation and research dissemination; 2) a georeferenced INVENTORY of all the built works by Siza, in Portugal and abroad; 3) constructive DOCUMENTATION and analysis of the 18 selected built works, supported by archival research and fieldwork, including surveys (photographic, photogrammetric and 3D visualization), record of the state of conservation, surveys to users and threats that affect the assets; 4) RECOMMENDATIONS based on the data collection and its analysis, to help prepare the process instruction for protection at national level, and for the nomination for World Heritage. Also, proposals for comparative analysis at national, international and World Heritage are developed contributing for the establishment of the OUV, as well as for the future management and monitoring of the selected works; 5) DISSEMINATION and transfer of knowledge of the work of Siza is one of the main focus of SizaATLAS, at a large scale, which will allow the exchange and dissemination of his work. This broad and interactive dissemination together with the WH nomination can potentially impact at the economic, social and cultural sector (namely tourism), in a strong connection with local and regional communities and stakeholders (municipalities, heritage offices, managers and owners). SizaATLAS research project contributes for knowledge through the study and enhancement of Portuguese architecture in an international framework; for the protection of Siza’s works at municipal, national and international level; and for a deeper reflection on its contribution to the 20th and even 21st century architecture, responding to the UNESCO Global Strategy; and assuring the diffusion and the preservation of Siza’s works for future generations.info:eu-repo/semantics/publishedVersio