Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Azúcar, patrimonio y paisaje en Cuba

CSIC - Instituto de Historia (IH), Colegio Universitario San Gerónimo de La Habana, Universidad de La Habana, Oficina del Historiador de La Habana (Cuba)Libro digital editado en el marco de los proyectos de investigación financiados por la Unión Europea: Connected Worlds: the Caribbean, Origin of Mondern World (ConnecCaribbean-823846, RI-SE. H2020-MSCA-RISE-2018)y el Ministerio de Economía y Competitividad de España: El Espacio Antillano: Génesis, Circulación y Redistribución de Individuos, Mercancías, Ideas, Saberes y Modelos, Siglos XVII-XXI (HAR2015-66152-R) e Historia de los Bancos en las Colonias Españolas, 1850-1899: Cuba, Puerto Rico y Filipinas(HAR2015-64085-P).Peer reviewe

Ferrocarril, historia, espacio y patriminio en Cuba

Ferrocarril, historia, espacio y patriminio en CubaPeer reviewe