120 research outputs found
Enhancing Network Slicing Architectures with Machine Learning, Security, Sustainability and Experimental Networks Integration
Network Slicing (NS) is an essential technique extensively used in 5G
networks computing strategies, mobile edge computing, mobile cloud computing,
and verticals like the Internet of Vehicles and industrial IoT, among others.
NS is foreseen as one of the leading enablers for 6G futuristic and highly
demanding applications since it allows the optimization and customization of
scarce and disputed resources among dynamic, demanding clients with highly
distinct application requirements. Various standardization organizations, like
3GPP's proposal for new generation networks and state-of-the-art 5G/6G research
projects, are proposing new NS architectures. However, new NS architectures
have to deal with an extensive range of requirements that inherently result in
having NS architecture proposals typically fulfilling the needs of specific
sets of domains with commonalities. The Slicing Future Internet Infrastructures
(SFI2) architecture proposal explores the gap resulting from the diversity of
NS architectures target domains by proposing a new NS reference architecture
with a defined focus on integrating experimental networks and enhancing the NS
architecture with Machine Learning (ML) native optimizations, energy-efficient
slicing, and slicing-tailored security functionalities. The SFI2 architectural
main contribution includes the utilization of the slice-as-a-service paradigm
for end-to-end orchestration of resources across multi-domains and
multi-technology experimental networks. In addition, the SFI2 reference
architecture instantiations will enhance the multi-domain and multi-technology
integrated experimental network deployment with native ML optimization,
energy-efficient aware slicing, and slicing-tailored security functionalities
for the practical domain.Comment: 10 pages, 11 figure
Avaliação do estado nutricional de agroecossistemas de café orgùnico no estado de Minas Gerais.
A produção de cafĂ© orgĂąnico vem se constituindo uma tendĂȘncia necessĂĄria e irreversĂvel do agronegĂłcio brasileiro. Essa atividade tem-se destacado como uma alternativa de renda para alguns cafeicultores, devido Ă crescente demanda mundial por alimentos mais saudĂĄveis. Entretanto, grande parte das tĂ©cnicas propostas pela agricultura orgĂąnica estĂĄ sendo aplicada empiricamente no cultivo de cafĂ©, principalmente no Estado de Minas Gerais, maior regiĂŁo produtora de cafĂ© do Brasil. Levando-se em consideração a baixa fertilidade natural dos solos dessa regiĂŁo cafeeira, bem como a elevada extração de nutrientes pelo cafeeiro, objetivou-se neste trabalho identificar possĂveis fatores limitantes para a produção orgĂąnica do cafeeiro, relacionados Ă fertilidade do solo e ao estado nutricional das plantas. Foram realizadas avaliaçÔes da fertilidade do solo e anĂĄlise das folhas em vinte e uma lavouras orgĂąnicas representativas do Estado de Minas Gerais. As amostras de solo foram analisadas para determinação do pH, acidez potencial e dos teores de P, K, Ca, Mg, S, Al e matĂ©ria orgĂąnica. As amostras foliares foram analisadas para determinação dos teores de N, P, K, Ca, Mg, S, B, Cu, Fe, Mn e Zn. Com base nos padrĂ”es de interpretação para cafeeiros convencionais propostos pela literatura, estabeleceram-se as freqĂŒĂȘncias com que os caracteres analisados foram inferiores aos critĂ©rios de interpretação da fertilidade do solo e estado nutricional das plantas. A anĂĄlise dos dados foi realizada por estatĂstica descritiva. Novos trabalhos nessa nova ĂĄrea sĂŁo necessĂĄrios, visando a uma melhor interpretação da anĂĄlise foliar e da fertilidade do solo, quando se trabalha com cafĂ© orgĂąnico
Binding hotspots of BAZ2B bromodomain: Histone interaction revealed by solution NMR driven docking.
Bromodomains are epigenetic reader domains, which have come under increasing scrutiny both from academic and pharmaceutical research groups. Effective targeting of the BAZ2B bromodomain by small molecule inhibitors has been recently reported, but no structural information is yet available on the interaction with its natural binding partner, acetylated histone H3K14ac. We have assigned the BAZ2B bromodomain and studied its interaction with H3K14ac acetylated peptides by NMR spectroscopy using both chemical shift perturbation (CSP) data and clean chemical exchange (CLEANEX-PM) NMR experiments. The latter was used to characterize water molecules known to play an important role in mediating interactions. Besides the anticipated Kac binding site, we consistently found the bromodomain BC loop as hotspots for the interaction. This information was used to create a data-driven model for the complex using HADDOCK. Our findings provide both structure and dynamics characterization that will be useful in the quest for potent and selective inhibitors to probe the function of the BAZ2B bromodomain.This is the final published version of the article. It has been published by the American Chemical Society in Biochemistry. The article can be accessed on their website here: http://pubs.acs.org/doi/abs/10.1021/bi500909d. It is freely available under a CC BY licence
A study of the scutellum in eight Chagas disease vector species from genus Triatoma (Hemiptera, Reduviidae) using optical and scanning electron microscopy
Repetibilidade de caracteres de produção e porte da planta em clones de cajueiro-anão precoce
Predictors of HBeAg status and hepatitis B viraemia in HIV-infected patients with chronic hepatitis B in the HAART era in Brazil
<p>Abstract</p> <p>Background</p> <p>HBV-HIV co-infection is associated with an increased liver-related morbidity and mortality. However, little is known about the natural history of chronic hepatitis B in HIV-infected individuals under highly active antiretroviral therapy (HAART) receiving at least one of the two drugs that also affect HBV (TDF and LAM). Information about HBeAg status and HBV viremia in HIV/HBV co-infected patients is scarce. The objective of this study was to search for clinical and virological variables associated with HBeAg status and HBV viremia in patients of an HIV/HBV co-infected cohort.</p> <p>Methods</p> <p>A retrospective cross-sectional study was performed, of HBsAg-positive HIV-infected patients in treatment between 1994 and 2007 in two AIDS outpatient clinics located in the SĂŁo Paulo metropolitan area, Brazil. The baseline data were age, sex, CD4 T+ cell count, ALT level, HIV and HBV viral load, HBV genotype, and duration of antiretroviral use. The variables associated to HBeAg status and HBV viremia were assessed using logistic regression.</p> <p>Results</p> <p>A total of 86 HBsAg patients were included in the study. Of these, 48 (56%) were using combination therapy that included lamivudine (LAM) and tenofovir (TDF), 31 (36%) were using LAM monotherapy, and 7 patients had no previous use of either one. Duration of use of TDF and LAM varied from 4 to 21 and 7 to 144 months, respectively. A total of 42 (48. 9%) patients were HBeAg positive and 44 (51. 1%) were HBeAg negative. The multivariate analysis revealed that the use of TDF for longer than 12 months was associated with undetectable HBV DNA viral load (serum HBV DNA level < 60 UI/ml) (<it>p </it>= 0. 047). HBeAg positivity was associated with HBV DNA > 60 UI/ml (p = 0. 001) and ALT levels above normality (<it>p </it>= 0. 038).</p> <p>Conclusion</p> <p>Prolonged use of TDF containing HAART is associated with undetectable HBV DNA viral load. HBeAg positivity is associated with HBV viremia and increased ALT levels.</p
THE INFLUENCE OF THE NUMBER OF LEAVES IN THE MACAĂBA PALM Acrocomia aculeata (Jacq.) Lodd. ex Mart. ON THE CORRELATION BETWEEN STEMFLOW AND GROSS PRECIPITATION
Comportamento de genĂłtipos de feijoeiro em latossolo vermelho distrofĂ©rrico tĂpico com diferentes graus de compactação
Effects of the condylar process fracture on facial symmetry in rats submitted to protein undernutrition
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