4 research outputs found
Sensitivity and specificity of in vivo COVID-19 screening by detection dogs: Results of the C19-Screendog multicenter study
Trained dogs can recognize the volatile organic compounds contained in biological samples of
patients with COVID-19 infection. We assessed the sensitivity and specificity of in vivo SARS-CoV-
2 screening by trained dogs.
We recruited five dog-handler dyads. In the operant conditioning phase, the dogs were taught to
distinguish between positive and negative sweat samples collected from volunteers’ underarms in
polymeric tubes. The conditioning was validated by tests involving 16 positive and 48 negative
samples held or worn in such a way that the samples were invisible to the dog and handler. In the
screening phase the dogs were led by their handlers to a drive-through facility for in vivo screening
of volunteers who had just received a nasopharyngeal swab from nursing staff. Each volunteer who
had already swabbed was subsequently tested by two dogs, whose responses were recorded as
positive, negative, or inconclusive. The dogs’ behavior was constantly monitored for attentiveness
and wellbeing.
All the dogs passed the conditioning phase, their responses showing a sensitivity of 83-100% and a
specificity of 94-100%. The in vivo screening phase involved 1251 subjects, of whom 205 had a
COVID-19 positive swab and two dogs per each subject to be screened. Screeningsensitivity and
specificity were respectively 91.6-97.6% and 96.3-100% when only one dog was involved, whereas
combined screening by two dogs provided a higher sensitivity. Dog wellbeing was also analysed:
monitoring of stress and fatigue suggested that the screening activity did not adversely impact the
dogs’ wellbeing. This work, by screening a large number of subjects, strengthen recent findings that
trained dogs can discriminate between COVID-19 infected and healthy human subjects and introduce
two novel research aspects: i) assessement of signs of fatigue and stress in dogs during training and
testing, and ii) combining screening by two dogs to improve detection sensitivity and specificity.
Using some precautions to reduce the risk of infection and spillover, in vivo COVID-19 screening by
a dog-handler dyad can be suitable to quickly screen large numbers of people: it is rapid, non-
invasiveand economical, since it does not involve actual sampling, lab resources or waste
management, and is suitable to screen large numbers of people
Automatic Morphological Analysis of Medial Temporal Lobe
none10A. CHINCARINI; M. COROSU; G. GEMME; P. CALVINI; M. MONGE; M. A. PENCO; L. REI; S. SQUARCIA; P. BOCCACCI; G. RODRIGUEZA., Chincarini; M., Corosu; G., Gemme; Calvini, Piero; Monge, MARIA ROBERTA; Penco, MARIA ANTONIETTA; L., Rei; Squarcia, Sandro; Boccacci, Patrizia; Rodriguez, Guid