Come back Marshall, all is forgiven? : Complexity, evolution, mathematics and Marshallian exceptionalism

Marshall was the great synthesiser of neoclassical economics. Yet with his qualified assumption of self-interest, his emphasis on variation in economic evolution and his cautious attitude to the use of mathematics, Marshall differs fundamentally from other leading neoclassical contemporaries. Metaphors inspire more specific analogies and ontological assumptions, and Marshall used the guiding metaphor of Spencerian evolution. But unfortunately, the further development of a Marshallian evolutionary approach was undermined in part by theoretical problems within Spencer's theory. Yet some things can be salvaged from the Marshallian evolutionary vision. They may even be placed in a more viable Darwinian framework.Peer reviewedFinal Accepted Versio

Constraints on dark matter-nucleon effective couplings in the presence of kinematically distinct halo substructures using the DEAP-3600 detector

DEAP-3600 is a single-phase liquid argon detector aiming to directly detect weakly interacting massive particles (WIMPs), located at SNOLAB (Sudbury, Canada). After analyzing data taken during the first year of operation, a null result was used to place an upper bound on the WIMP-nucleon, spin-independent, isoscalar cross section. This study reinterprets this result within a nonrelativistic effective field theory framework and further examines how various possible substructures in the local dark matter halo may affect these constraints. Such substructures are hinted at by kinematic structures in the local stellar distribution observed by the Gaia satellite and other recent astronomical surveys. These include the Gaia Sausage (or Enceladus), as well as a number of distinct streams identified in recent studies. Limits are presented for the coupling strength of the effective contact interaction operators O1, O3, O5, O8, and O11, considering isoscalar, isovector, and xenonphobic scenarios, as well as the specific operators corresponding to millicharge, magnetic dipole, electric dipole, and anapole interactions. The effects of halo substructures on each of these operators are explored as well, showing that the O5 and O8 operators are particularly sensitive to the velocity distribution, even at dark matter masses above 100 GeV=c

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Welfare Impact of Carbon Dioxide Euthanasia on Laboratory Mice and Rats: A Systematic Review

Contains fulltext : 225409.pdf (publisher's version ) (Open Access)Background: There has been increased concern about the suitability of CO(2) as a method for euthanasia of laboratory mice and rats, including the potential discomfort, pain or distress that animals may experience prior to loss of consciousness; time to loss of consciousness; best methods for use of CO(2); and the availability of better alternatives. These discussions have been useful in providing new information, but have resulted in significant confusion regarding the acceptability of CO(2) for rodent euthanasia. In some cases, researchers and veterinarians have become uncertain as to which techniques to recommend or use for euthanasia of laboratory mice and rats. Methods: The International Association of Colleges of Laboratory Animal Medicine (IACLAM) convened a taskforce to examine the evidence for adverse welfare indicators in laboratory rats and mice undergoing CO(2) euthanasia using a SYRCLE-registered systematic review protocol. Of 3,772 papers identified through a database search (PubMed, Web of Science, CAB Direct, Agricola, and grey literature) from 1900 to 2017, 37 studies were identified for detailed review (some including more than one species or age group), including 15 in adult mice, 21 in adult rats, and 5 in neonates of both species. Experiments or reports were excluded if they only assessed parameters other than those directly affecting animal welfare during CO(2) induction and/or euthanasia. Results: Study design and outcome measures were highly variable and there was an unclear to high risk of bias in many of the published studies. Changes in the outcome measures evaluated were inconsistent or poorly differentiated. It is likely that repeated exposures to carbon dioxide inhalation are aversive to adult rats and mice, based on avoidance behavior studies; however, this effect is largely indistinguishable from aversion induced by repeated exposures to other inhalant anesthetic gasses. Conclusion: There is insufficient evidence to permit an unbiased assessment of the effect of CO(2) inhalation during euthanasia on welfare indicators in laboratory mice and rats. Additional well-designed, unbiased, and adequately powered studies are needed to accurately assess the welfare of laboratory mice and rats undergoing euthanasia via CO(2) gas

Ultraviolet-induced fluorescence of poly(methyl methacrylate) compared to 1,1,4,4-tetraphenyl-1,3-butadiene down to 4 K

Several particle-physics experiments use poly(methyl methacrylate) (a.k.a. PMMA or acrylic) vessels to contain liquid scintillators. Superluminal charged particles emitted from radioactive impurities in or near the acrylic can emit Cherenkov radiation in the ultraviolet (UV) spectra range. If acrylic fluoresces in the visible range due to this UV light, it could be a source of background in experiments where the main signal is visible scintillation light, or UV scintillation light that is absorbed and re-emitted at visible wavelengths by a wavelength shifter. Some of these experiments operate at low temperature. The fluorescence of these materials could change with temperature so we have studied the fluorescence of the acrylic used in the DEAP-3600 experiment down to a temperature of 4 K, and compared it to the common wavelength shifter 1,1,4,4-tetraphenyl-1,3-butadiene (TPB). The light yield and wavelength spectra of these materials were characterized by exciting the sample with 285 nm UV light, which acted as a proxy for Cherenkov light in the detector. Spectral measurements indicate at least part of the fluorescence of the acrylic is due to additives. Time-resolved measurements show the light yields of our acrylic sample, TPB sample, and the relative light between both samples, all increase when cooling down. At room temperature, the light yield of our acrylic sample relative to the TPB sample is 0.27%, while it reaches 0.48% at 4 K. The main fluorescence time constant of the acrylic is less than a few nanoseconds

Ultraviolet-induced fluorescence of poly(methyl methacrylate) compared to 1,1,4,4-tetraphenyl-1,3-butadiene down to 4 K

Several particle-physics experiments use poly(methyl methacrylate) (a.k.a. PMMA or acrylic) vessels to contain liquid scintillators. Superluminal charged particles emitted from radioactive impurities in or near the acrylic can emit Cherenkov radiation in the ultraviolet (UV) spectra range. If acrylic fluoresces in the visible range due to this UV light, it could be a source of background in experiments where the main signal is visible scintillation light, or UV scintillation light that is absorbed and re-emitted at visible wavelengths by a wavelength shifter. Some of these experiments operate at low temperature. The fluorescence of these materials could change with temperature so we have studied the fluorescence of the acrylic used in the DEAP-3600 experiment down to a temperature of 4 K, and compared it to the common wavelength shifter 1,1,4,4-tetraphenyl-1,3-butadiene (TPB). The light yield and wavelength spectra of these materials were characterized by exciting the sample with 285 nm UV light, which acted as a proxy for Cherenkov light in the detector. Spectral measurements indicate at least part of the fluorescence of the acrylic is due to additives. Time-resolved measurements show the light yields of our acrylic sample, TPB sample, and the relative light between both samples, all increase when cooling down. At room temperature, the light yield of our acrylic sample relative to the TPB sample is 0.27%, while it reaches 0.48% at 4 K. The main fluorescence time constant of the acrylic is less than a few nanoseconds

Ultraviolet-induced fluorescence of poly(methyl methacrylate) compared to 1,1,4,4-tetraphenyl-1,3-butadiene down to 4 K

Several particle-physics experiments use poly(methyl methacrylate) (a.k.a. PMMA or acrylic) vessels to contain liquid scintillators. Superluminal charged particles emitted from radioactive impurities in or near the acrylic can emit Cherenkov radiation in the ultraviolet (UV) spectra range. If acrylic fluoresces in the visible range due to this UV light, it could be a source of background in experiments where the main signal is visible scintillation light, or UV scintillation light that is absorbed and re-emitted at visible wavelengths by a wavelength shifter. Some of these experiments operate at low temperature. The fluorescence of these materials could change with temperature so we have studied the fluorescence of the acrylic used in the DEAP-3600 experiment down to a temperature of 4 K, and compared it to the common wavelength shifter 1,1,4,4-tetraphenyl-1,3-butadiene (TPB). The light yield and wavelength spectra of these materials were characterized by exciting the sample with 285 nm UV light which acted as a proxy for Cherenkov light in the detector. Spectral measurements indicate at least part of the fluorescence of the acrylic is due to additives. Time-resolved measurements show the light yields of our acrylic sample, TPB sample, and the relative light between both samples, all increase when cooling down. At room temperature, the light yield of our acrylic sample relative to the TPB sample is 0.3 %, while it reaches 0.5 % at 4 K. The main fluorescence time constant of the acrylic is less than a few nanoseconds

The bioeconomics of homogeneous middleman groups as adaptive units: Theory and empirical evidence viewed from a group selection framework

Adaptation, Complex regulatory mechanisms, Major life transitions, Social norms, Institutions, Trust, Kinship, Ethnicity, Clubs, Multilevel selection, Cultural group selection, In-group cooperation, Between-group competition, Cultural bearing and transmission units, Dual-inheritance theory, Ethnocentrism, D23, D71, D86, L14, 017, Z12, Z13,