Learning from users for radical innovation

In today's environment of rapid technological change companies can not rely on incremental innovations alone. To sustain long-term competitiveness companies need to develop radical innovations as well. Such innovations typically incorporate new and highly complex technologies, create new markets or shift existing market structures, and require user learning as they often induce significant behaviour changes on side of the users. To systematically develop radical innovations firms need to involve the proper actors. One such important external actor in the development process of new products is the user. Our study focuses on the question what kind of users are able to actively contribute to the development of radical innovations and what firms can learn from them to improve their innovative capability. A multiple case study analysis was conducted in the field of medical technology. Five radical innovation projects were selected including medical robots and computer-assisted navigation systems. The case study analysis reveals that users with a unique set of characteristics can contribute substantially to the development of radical innovations. These users have a high motivation toward new solutions, are open to new technologies, possess diverse competencies, and are embedded into a very supportive context. Manufacturers that took over the ideas and prototypes of the inventive users benefited significantly. By learning from these users, firms were able to significantly improve their radical innovative capability. The paper contributes to technology and innovation management research in two ways. First, by exploring critical user characteristics for distinct phases of the radical innovation process, we provide first insights how manufacturing firms can more effectively identify and leverage valuable users for their radical innovation work. Thereby, we highlight the involvement of capable users as an effective learning mechanism to improve the radical innovation capability of a firm. Second, new perspectives on lead user research are provided by enriching the lead user concept with other crucial characteristics of innovative users. --Produktinnovation,Produktentwicklung,Benutzer / Beteiligung

Probate Document Regarding Estates of John P. Varnum, Josephine L. Varnum, Nora Varnum

State of Florida, County of Hillsboro...no record of any administration or probate proceedings upon the estates of John P. Varnum, Josephine L. Varnum or Nora Varnum...September 13, 1926

The Poisson Bracket for Poisson Forms in Multisymplectic Field Theory

We present a general definition of the Poisson bracket between differential forms on the extended multiphase space appearing in the geometric formulation of first order classical field theories and, more generally, on exact multisymplectic manifolds. It is well defined for a certain class of differential forms that we propose to call Poisson forms and turns the space of Poisson forms into a Lie superalgebra.Comment: 40 pages LaTe

Genetic expression of an amyloid peptide fragment and analysis of formylated products

The model amyloid peptide AAKLVFF was expressed as a His-tagged fusion protein with the immunoglobulin-binding domain B1 of streptococcal protein G (GB1), a small (56 residues), stable, single-domain protein. It is shown that expression of this model amyloid peptide is possible and is not hindered by aggregation. Formylation side reactions during the CNBr cleavage are investigated via synthesis of selectively formylated peptides

Field-induced magnetic transitions in the quasi-two-dimensional heavy-fermion antiferromagnets Ce_{n}RhIn_{3n+2} (n=1 or 2)

We have measured the field-dependent heat capacity in the tetragonal antiferromagnets CeRhIn$_{5}$ and Ce$_{2}$RhIn$_{8}$, both of which have an enhanced value of the electronic specific heat coefficient $\gamma \sim 400$ mJ/mol-Ce K$^{2}$ above $T_{N}$. For $T<T_{N},$ the specific heat data at zero applied magnetic field are consistent with the existence of an anisotropic spin-density wave opening a gap in the Fermi surface for CeRhIn$_{5},$ while Ce$_{2}$RhIn$_{8}$ shows behavior consistent with a simple antiferromagnetic magnon. From these results, the magnetic structure, in a manner similar to the crystal structure, appears more two-dimensional in CeRhIn$_{5}$ than in Ce$_{2}$RhIn$_{8}$ where only about 12% of the Fermi surface remains ungapped relative to 92% for Ce$_{2}$RhIn$_{8}$. When $B||c,$ both compounds behave in a manner expected for heavy fermion systems as both $T_{N}$ and the electronic heat capacity decrease as field is applied. When the field is applied in the tetragonal basal plane ($B||a$), CeRhIn$_{5}$ and Ce$_{2}$RhIn$_{8}$ have very similar phase diagrams which contain both first- and second-order field-induced magnetic transitions .Comment: 15 pages, 4 figure

Localized f electrons in CexLa1-xRhIn5: dHvA Measurements

Measurements of the de Haas-van Alphen effect in CexLa1-xRhIn5 reveal that the Ce 4f electrons remain localized for all x, with the mass enhancement and progressive loss of one spin from the de Haas-van Alphen signal resulting from spin fluctuation effects. This behavior may be typical of antiferromagnetic heavy fermion compounds, inspite of the fact that the 4f electron localization in CeRhIn5 is driven, in part, by a spin-density wave instability.Comment: 4 pages, 4 figures, submitted to PR

From brain to spinal cord: neuromodulation by direct current stimulation and its promising effects as a treatment option for restless legs syndrome

Neuromodulation is a fast-growing field of mostly non-invasive therapies, which includes spinal cord stimulation (SCS), transcranial direct current stimulation (tDCS), vagal nerve stimulation (VNS), peripheral nerve stimulation, transcranial magnetic stimulation (TMS) and transcutaneous spinal direct current stimulation (tsDCS). This narrative review offers an overview of the therapy options, especially of tDCS and tsDCS for chronic pain and spinal cord injury. Finally, we discuss the potential of tsDCS in Restless Legs Syndrome as a promising non-invasive, alternative therapy to medication therapy

Specific Heat of Ce(1-x)La(x)RhIn(5) in Zero and Applied Magnetic Field: A Very Rich Phase Diagram

Specific heat and magnetization results as a function of field on single- and poly-crystalline samples of Ce(1-x)La(x)RhIn(5) show 1.) a specific heat gamma of about 100 mJ/moleK^2 (in agreement with recent dHvA results of Alvers et al.); 2.) upturns at low temperatures in C/T and chi that fit a power law behavior ( Griffiths phase non-Fermi liquid behavior); 3.) a field induced anomaly in C/T as well as M vs H behavior in good agreement with the recent Griffiths phase theory of Castro Neto and Jones, where M~H at low field, M ~ H^lambda above a crossover field, C/T ~ T^(-1+lambda) at low field, and C/T ~ (H^(2+lambda/2)/T^(3-lambda/2))*exp(-mu(eff)H/T) above the same crossover field as determined in the magnetization and where lambda is independently determined from the temperature dependence of chi at low temperatures, chi ~ T^(-1+lambda) and low fields.Comment: 13 pages, 9 figures, to be published in Physical Review

Heat capacity studies of Ce and Rh site substitution in the heavy fermion antiferromagnet CeRhIn_5;: Short-range magnetic interactions and non-Fermi-liquid behavior

In heavy fermion materials superconductivity tends to appear when long range magnetic order is suppressed by chemical doping or applying pressure. Here we report heat capacity measurements on diluted alloyes of the heavy fermion superconductor CeRhIn_5;. Heat capacity measurements have been performed on CeRh_{1-y}Ir_{y}In_5; (y <= 0.10) and Ce_{1-x}La_{x}Rh_{1-y}Ir_{y}In_5; (x <= 0.50) in applied fields up to 90 kOe to study the affect of doping and magnetic field on the magnetic ground state. The magnetic phase diagram of CeRh_{0.9}Ir_{0.1}In_5; is consistent with the magnetic structure of CeRhIn_5; being unchanged by Ir doping. Doping of Ir in small concentrations is shown to slightly increase the antiferromagnetic transition temperature T_{N} (T_{N}=3.8 K in the undoped sample). La doping which causes disorder on the Ce sublattice is shown to lower T_{N} with no long range order observed above 0.34 K for Ce_{0.50}La_{0.50}RhIn_5;. Measurements on Ce_{0.50}La_{0.50}RhIn_5; show a coexistence of short range magnetic order and non-Fermi-liquid behavior. This dual nature of the Ce 4f-electrons is very similar to the observed results on CeRhIn_5; when long range magnetic order is suppressed at high pressure.Comment: 8 pages, 9 figure

Absence of Hybridization Gap in Heavy Electron Systems and Analysis of YbAl3 in terms of Nearly Free Electron Conduction Band

In the analysis of the heavy electron systems, theoretical models with c-f hybridization gap are often used. We point out that such a gap does not exist and the simple picture with the hybridization gap is misleading in the metallic systems, and present a correct picture by explicitly constructing an effective band model of YbAl_3. Hamiltonian consists of a nearly free electron model for conduction bands which hybridize with localized f-electrons, and includes only a few parameters. Density of states, Sommerfeld coefficient, f-electron number and optical conductivity are calculated and compared with the band calculations and the experiments.Comment: 9 pages, 9 figures, submitted to J. Phys. Soc. Jp