RAFA Trial Results: High Dose Rifampicin Tuberculosis treatment regimen to reduce 12 month mortality of TB/HIV co-infected patients

RAFA Trial Results: High Dose Rifampicin Tuberculosis treatment regimen to reduce 12 month mortality of TB/HIV co-infected patients - Corinne Merle.<br><br>This presentation was delivered at the 2017 INTERTB symposium, held at St George’s, University of London. The full collection of outputs from the meeting can be accessed from the link referenced below

Assignability of the Claim to Initiate the Investment Arbitration Proceedings According to UNCITRAL Arbitration Rules

Sensitivity analysis – multivariable random effects logistic regression of the association between clinician caseload and treatment outcomes in a restricted dataset of 10 hospitals. Sensitivity analysis restricted to 4,884 cases from 10 hospitals where the named clinician field was further checked. (DOCX 16 kb

Additional file 1: of Towards better guidance on caseload thresholds to promote positive tuberculosis treatment outcomes: a cohort study

Treatment outcomes at 12 months. Table of categorised treatment outcomes. (DOCX 21 kb

Tracking the career development of scientists in low- and middle-income countries trained through TDR’s research capacity strengthening programmes: Learning from monitoring and impact evaluation

<div><p>The Special Programme for Research and Training in Tropical Diseases (TDR) co-sponsored by UNICEF, UNDP, World Bank and WHO has been supporting research capacity strengthening in low- and middle-income countries for over 40 years. In order to assess and continuously optimize its capacity strengthening approaches, an evaluation of the influence of TDR training grants on research career development was undertaken. The assessment was part of a larger evaluation conducted by the European Science Foundation. A comprehensive survey questionnaire was developed and sent to a group of 117 trainees supported by TDR who had completed their degree (masters or PhD) between 2000 and 2012; of these, seventy seven (77) responded. Most of the respondents (80%) rated TDR support as a very important factor that influenced their professional career achievements. The “brain drain” phenomenon towards high-income countries was particularly low amongst TDR grantees: the rate of return to their region of origin upon completion of their degree was 96%. A vast majority of respondents are still working in research (89%), with 81% of respondents having participated in multidisciplinary research activities; women engaged in multidisciplinary collaboration to a higher extent than men. However, only a minority of all have engaged in intersectoral collaboration, an aspect that would require further study. The post-degree career choices made by the respondents were strongly influenced by academic considerations. At the time of the survey, 92% of all respondents hold full-time positions, mainly in the public sector. Almost 25% of the respondents reported that they had influenced policy and practice changes. Some of the challenges and opportunities faced by trainees at various stages of their research career have been identified. Modalities to overcome these will require further investigation. The survey evidenced how TDR’s research capacity grant programmes made a difference on researchers’ career development and on south-south collaborations, by strengthening and localizing research capacity in lower income regions, and also showed there is more that needs to be done. The factors involved, challenges and lessons learnt may help donors and policy makers improve their future interventions with regard to designing capacity strengthening programmes and setting funding priorities.</p></div

Profile of the 77 TDR trainees who responded to the survey.

<p>(A) geographic distribution by WHO region (AFR for African region; AMR for region of the Americas, SEAR for South East Asia region, EMR for Eastern Mediterranean region and WPR for Western Pacific region); (B, C) gender distribution in total and by WHO region, respectively; (D) use of language in AFR; (E) employment status of trainees by function (E1), and by nature (E2 and E3).</p

Occupational area and gender of TDR respondents (in %) (percentages do not add up to 100% since respondents can work in more than one occupational area).

<p>Occupational area and gender of TDR respondents (in %) (percentages do not add up to 100% since respondents can work in more than one occupational area).</p

TDR respondents by career stage (Frascati definition) [7, 8] and gender (in %).

<p>TDR respondents by career stage (Frascati definition) [<a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0006112#pntd.0006112.ref007" target="_blank">7</a>, <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0006112#pntd.0006112.ref008" target="_blank">8</a>] and gender (in %).</p

Characteristics of patients.

<p>Characteristics of patients.</p

Prevalence of ATLI by NAT genotype.

<p>Prevalence of ATLI by NAT genotype.</p

Definition of acetylator status according to NAT2 genotypes.

<p>Definition of acetylator status according to NAT2 genotypes.</p