How and Why Strategy Instruction Can Improve Second Language Reading Comprehension: A review

Increasingly, children enter the school system with a home language that differs from the language of the majority. Consequently, classrooms have students with diverse language backgrounds and teachers must develop reading comprehension instruction that meets the needs of all their students. To successfully plan instruction, it is critical for teachers to understand the strengths that second language learners (SLLs) bring to the classroom as well as the potential difficulties they face. Here we review the literature on reading comprehension development and utilize cognitive frameworks to describe the knowledge, skills, and processes involved during reading for meaning. We use these theories to explain why SLLs may have difficulty with reading comprehension and how we might leverage their strengths in domains such as executive control to support their reading comprehension development. We further highlight for educators how strategy instruction aligns directly with cognitive theories of reading comprehension. Ideally, 2 such examples will enable educators to explicitly articulate for their students how effective strategies enable the development of comprehensive mental representations of the text, and ultimately enable good text comprehension

The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer

Prostate cancer (PCa) is a leading cause of cancer-related deaths and is driven by aberrant androgen receptor (AR) signalling. For this reason, androgen deprivation therapies (ADTs) that suppress androgen-induced PCa progression either by preventing androgen biosynthesis or via AR signalling inhibition (ARSi) are common treatments. The N6-methyladenosine (m6A) RNA modification is involved in regulating mRNA expression, translation, and alternative splicing, and through these mechanisms has been implicated in cancer development and progression. RNA-m6A is dynamically regulated by the METTL3 RNA methyltransferase complex and the FTO and ALKBH5 demethylases. While there is evidence supporting a role for aberrant METTL3 in many cancer types, including localised PCa, the wider contribution of METTL3, and by inference m6A, in androgen signalling in PCa remains poorly understood. Therefore, the aim of this study was to investigate the expression of METTL3 in PCa patients and study the clinical and functional relevance of METTL3 in PCa. It was found that METTL3 is aberrantly expressed in PCa patient samples and that siRNA-mediated METTL3 knockdown or METTL3-pharmacological inhibition significantly alters the basal and androgen-regulated transcriptome in PCa, which supports targeting m6A as a novel approach to modulate androgen signalling in PCa