Klinefelter syndrome: cardiovascular abnormalities and metabolic disorders

Klinefelter syndrome (KS) is one of the most common genetic causes of male infertility. This condition is associated with much comorbidity and with a lower life expectancy. The aim of this review is to explore more in depth cardiovascular and metabolic disorders associated to KS. KS patients have an increased risk of cerebrovascular disease (standardized mortality ratio, SMR, 2.2; 95% confidence interval, CI, 1.6–3.0), but it is not clear whether the cause of the death is of thrombotic or hemorrhagic nature. Cardiovascular congenital anomalies (SMR, 7.3; 95% CI, 2.4–17.1) and the development of thrombosis or leg ulcers (SMR, 7.9; 95% CI, 2.9–17.2) are also more frequent in these subjects. Moreover, cardiovascular abnormalities may be at least partially reversed by testosterone replacement therapy (TRT). KS patients have also an increased probability of endocrine and/or metabolic disease, especially obesity, metabolic syndrome and type 2 diabetes mellitus. The effects of TRT on these abnormalities are not entirely clear

Natura, macchine, cervello e conoscenza. Attualità del pensiero di Vittorio Somenzi

Si tratta di un saggio sulla figura di Vittorio Somenzi, introduttivo al volume antologico

L’Intelligenza Artificiale: la storia e le idee

Scopo di questo capitolo è di introdurre il lettore ai principali argomenti che, nel corso della sua breve storia, l’Intelligenza Artificiale (IA) ha affrontato sia nella variante applicativa o ingegneristica sia in quella teorica o cognitiva. Alla fine di questo capitolo il lettore dovrebbe avere presente l’evoluzione di alcune delle tendenze di ricerca più influenti in IA, essere al corrente delle più recenti posizioni nel dibattito attuale all’interno dell’IA, essere brevemente introdotto ad alcuni classici problemi filosofici ed epistemologici affrontati dall’IA

What levels of explanation in the behavioural sciences?

Complex systems are to be seen as typically having multiple levels of organization. For instance, in the behavioural and cognitive sciences, there has been a long lasting trend, promoted by the seminal work of David Marr, putting focus on three distinct levels of analysis: the computational level, accounting for the What and Why issues, the algorithmic and the implementational levels specifying the How problem. However, the tremendous developments in neuroscience knowledge about processes at different scales of organization together with the complexity of today cognitive theories suggest that there will hardly be only three levels of explanation. Instead, there will be many different degrees of commitments corresponding to the different granularities - from high-level (behavioural) models to low-level (neural and molecular) models of the cognitive research program. For instance, Bayesian approaches, that are usually advocated for formalizing Marr's computational level and rational behaviour, have even been adopted to model synaptic plasticity and axon guidance by molecular gradients. As a result, we can consider the behavioural scientist as dealing with models at a multiplicity of levels. The purpose of this Research Topic in Frontiers in Theoretical and Philosophical Psychology is to promote an approach to the role of the levels and explanation and models which is of interest for cognitive scientists, neuroscientists, psychologists, behavioural scientists, and philosophers of science

Intelligent machines and warfare: historical debates and epistemologically motivated concerns

The early examples of self-directing robots attracted the interest of both scientific and military communities. Biologists regarded these devices as material models of animal tropisms. Engineers envisaged the possibility of turning self-directing robots into new “intelligent” torpedoes during World War I. Starting from World War II, more extensive interactions developed between theoretical inquiry and applied military research on the subject of adaptive and intelligent machinery. Pioneers of Cybernetics were involved in the development of goal-seeking warfare devices. But collaboration occasionally turned into open dissent. Founder of Cybernetics Norbert Wiener, in the aftermath of World War II, argued against military applications of learning machines, by drawing on epistemological appraisals of machine learning techniques. This connection between philosophy of science and techno-ethics is both strengthened and extended here. It is strengthened by an epistemological analysis of contemporary machine learning from examples; it is extended by a reflection on ceteris paribus conditions for models of adaptive behaviours

Petrous bone cholesteatoma and facial paralysis

This paper describes a series of patients with a petrous temporal bone cholesteatoma paying particular attention to the complications and their management. Sixteen patients who underwent surgery in our department were reviewed. Topographically, the petrous bone choleasteatomas were grouped into five categories according to the classification proposed by Sanna et al. There were five massive labyrinthine; five infralabyrinthine; one apical, four supralabyrinthine; and one infralabyrinthine-apical. Clinically, the presenting symptom of these lesions were facial nerve paralysis (10 patients) and unilateral deafness (13 patients). Total removal of the cholesteatomas was achieved in all patients using different surgical approaches according to their site and extent. Recurrences were observed in two patients after 8 months and 24 months, respectively. The facial nerve was infiltrated and compressed by the cholesteatoma in eight patients. Seven were managed with cable grafts using sural nerve. One of these patients was treated using a facial-hypoglossal anastomosis because of the failure of the graft. In the remaining patient, a baby-sitter procedure was employed. In the other two patients, the preoperative facial paralysis was due to compression by the cholesteatoma, and its removal allowed partial recovery of facial function. The rationale of the surgical management of petrous bone cholesteatoma is its radical and total removal. Our present policy is to prefer approaches which result in a closed cavity obliterating the eustachian tube and closing the auditory canal as a blind sac. Facial nerve function is the main complication of these lesions. Facial nerve involvement requires rapid management because the duration of the paralysis is directly related to poor recovery of facial function

The notion of loop in the study of consciousness

The notion of loop seems to be ubiquitous in the study of organisms, the human mind and symbolic systems. With the possible exception of quantum-mechanical approaches, the treatments of consciousness we are acquainted with crucially appeal to the concept of loop. The uses of loops in this context fall within two broad classes. In the first one, loops are used to express the control of the organism’s interaction with the environment; in the second one, they are used to express self-reference. Both classes are tied with investigations which aim at accounting for symbolic capabilities, and ultimately for subjectivity. Neurophysiological research detects loops in the animal nervous system since its very inception (e.g., all the work on the reflex arc). Recently, Gray proposed a model purporting to explain the mechanism supporting the contents of consciousness in the human CNS, in ways that are practically indistinguishable from models formulated within the cybernetical point of view. Both types of models apply loops in strikingly similar ways. While there is no conclusive evidence that loops are necessary to support consciousness, they are nonetheless as good a candidate as today can be found for inclusion in the list of essential ingredients for subjectivity to arise. In the first two sections we discuss the above mentioned uses by means of significant examples. In the third section, we compare Gray’s recent model to MacKay’s early cybernetical model of a selfobserving system, in the setting of a broader discussion on loops for consciousness