Context-Aware Behavioral Tips to Improve Sleep Quality via Machine Learning and Large Language Models

As several studies demonstrate, good sleep quality is essential for individuals’ well-being, as a lack of restoring sleep may disrupt different physical, mental, and social dimensions of health. For this reason, there is increasing interest in tools for the monitoring of sleep based on personal sensors. However, there are currently few context-aware methods to help individuals to improve their sleep quality through behavior change tips. In order to tackle this challenge, in this paper, we propose a system that couples machine learning algorithms and large language models to forecast the next night’s sleep quality, and to provide context-aware behavior change tips to improve sleep. In order to encourage adherence and to increase trust, our system includes the use of large language models to describe the conditions that the machine learning algorithm finds harmful to sleep health, and to explain why the behavior change tips are generated as a consequence. We develop a prototype of our system, including a smartphone application, and perform experiments with a set of users. Results show that our system’s forecast is correlated to the actual sleep quality. Moreover, a preliminary user study suggests that the use of large language models in our system is useful in increasing trust and engagement

The interpretation of disease phenotypes to identify TSE strains in mice: characterisation of BSE using PrP^Sc distribution patterns in the brain

Abstract In individual animals affected by transmissible spongiform encephalopathies, different disease phenotypes can be identified which are attributed to different strains of the agent. In the absence of reliable technology to fully characterise the agent, classification of disease phenotype has been used as a strain typing tool which can be applied in any host. This approach uses standardised data on biological parameters, established for a single host, to allow comparison of different prion sources. Traditionally prion strain characterisation in wild type mice is based on incubation periods and lesion profiles after the stabilisation of the agent into the new host which requires serial passages. Such analysis can take many years, due to prolonged incubation periods. The current study demonstrates that the PrPSc patterns produced by one serial passage in wild type mice of bovine or ovine BSE were consistent, stable and showed minimal and predictable differences from mouse-stabilised reference strains. This biological property makes PrPSc deposition pattern mapping a powerful tool in the identification and definition of TSE strains on primary isolation, making the process of characterisation faster and cheaper than a serial passage protocol. It can be applied to individual mice and therefore it is better suited to identify strain diversity within single inocula in case of co-infections or identify strains in cases where insufficient mice succumb to disease for robust lesion profiles to be constructed. The detailed description presented in this study provides a reference document for identifying BSE in wild type mice.</p

Global guidelines trends and controversies in lower limb venous and lymphatic disease: Narrative literature revision and experts\u27 opinions following the vWINter international meeting in Phlebology, Lymphology & Aesthetics, 23-25 January 2019.

Guidelines are fundamental in addressing everyday clinical indications and in reporting the current evidence-based data of related scientific investigations. At the same time, a spatial and temporal issue can limit their value. Indeed, variability in the recommendations can be found both among the same nation different scientific societies and among different nations/continents. On the other side, Garcia already published in 2014 data showing how, after three years in average, one out of five recommendations gets outdated (Martinez Garcia LM, Sanabria AJ, Garcia Alvarez E, et al. The validity of recommendations from clinical guidelines: a survival analysis. CMAJ 2014;186(16):1211-1219). The present document reports a narrative literature revision on the major international recommendations in lower limb venous and lymphatic disease management, focusing on the different countries' guidelines, trends and controversies from all the continents, while identifying new evidence-based data potentially influencing future guidelines. World renowned experts' opinions are also provided. The document has been written following the recorded round tables scientific discussions held at the vWINter international meeting (22-26 January 2019; Cortina d'Ampezzo, Italy) and the pre- and post-meeting literature search performed by the leading experts