37 research outputs found

    Coherence and transparency: some advice for qualitative researchers

    Get PDF
    This is an Open Access Article. It is published by Brazilian Association of Production Engineering (ABEPRO) under the Creative Commons Attribution 4.0 International Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/There is relatively little advice in the Engineering domain for undertaking qualitative studies. Researchers have to rely on generic guidance that may result in imprecise application of qualitative methods. A related discipline to Engineering is Information Systems (IS) and the experiences of the IS domain may provide some useful insights for undertaking qualitative studies. This paper synthesizes the guidance from the IS community for crafting high quality qualitative studies and manuscripts. It reports on five themes: i) Establishing philosophical underpinnings; ii) Clarifying theoretical aims; iii) Selecting qualitative methods; iv) Demonstrating rigour in qualitative data analysis; and v) Grappling with generalisation. The review stresses the importance of coherence and transparency for crafting qualitative research manuscripts and provides a list of reflective questions for qualitative research design

    Recommendations for Addressing Priority Io Science in the Next Decade

    Get PDF
    Io is a priority destination for solar system exploration. The scope and importance of science questions at Io necessitates a broad portfolio of research and analysis, telescopic observations, and planetary missions - including a dedicated New Frontiers class Io mission

    The Science Case for Io Exploration

    Get PDF
    Io is a priority destination for solar system exploration, as it is the best natural laboratory to study the intertwined processes of tidal heating, extreme volcanism, and atmosphere-magnetosphere interactions. Io exploration is relevant to understanding terrestrial worlds (including the early Earth), ocean worlds, and exoplanets across the cosmos

    Numerical methods for multi-scale cell migration models

    No full text
    We study a multi-scale model for growth of malignant gliomas in the human brain. Interactions of individual glioma cells with their environment determine the gross tumor shape. We connect models on different time and length scales to derive a practical description of tumor growth that takes these microscopic interactions into account. From a simple subcellular model for haptotactic interactions of glioma cells with the white matter we derive a microscopic particle system, which leads to a meso-scale model for the distribution of particles, and finally to a macroscopic description of the cell density. The main body of this work is dedicated to the development and study of numerical methods adequate for the meso-scale transport model and its transition to the macroscopic limit.Wir betrachten ein Modell für das Wachstum bösartiger Gliome im menschlichen Gehirn. Die Form des gesamten Tumors ist eine direkte Folge von Interaktionen einzelner Krebszellen mit ihrer Umgebung. Indem wir Modelle auf verschiedenen Zeit und Längenskalen miteinander verknüpfen erhalten wir eine praktische Beschreibung des Tumorwachstums, die diese mikroskopischen Interaktionen berücksichtigt. Ausgehend von einem einfachen Modell für die Interaktionen zwischen Gliomenzellen und der weißen Materie stellen wir zuerst ein mikroskopisches Partikelsystem auf, aus dem wir eine Transportgleichung für die Zellverteilung auf der Mesoskala, und schließlich eine makroskopische Beschreibung der Zelldichte herleiten. Im Hauptteil der Arbeit entwickeln und analysieren wir geeignete numerische Methoden für das Transportmodell für Gliomenausbreitung und den Übergang zu dessen makroskopischen Grenzwert

    Numerical methods for multi-scale cell migration models

    No full text
    We study a multi-scale model for growth of malignant gliomas in the human brain. Interactions of individual glioma cells with their environment determine the gross tumor shape. We connect models on different time and length scales to derive a practical description of tumor growth that takes these microscopic interactions into account. From a simple subcellular model for haptotactic interactions of glioma cells with the white matter we derive a microscopic particle system, which leads to a meso-scale model for the distribution of particles, and finally to a macroscopic description of the cell density. The main body of this work is dedicated to the development and study of numerical methods adequate for the meso-scale transport model and its transition to the macroscopic limit.Wir betrachten ein Modell für das Wachstum bösartiger Gliome im menschlichen Gehirn. Die Form des gesamten Tumors ist eine direkte Folge von Interaktionen einzelner Krebszellen mit ihrer Umgebung. Indem wir Modelle auf verschiedenen Zeit und Längenskalen miteinander verknüpfen erhalten wir eine praktische Beschreibung des Tumorwachstums, die diese mikroskopischen Interaktionen berücksichtigt. Ausgehend von einem einfachen Modell für die Interaktionen zwischen Gliomenzellen und der weißen Materie stellen wir zuerst ein mikroskopisches Partikelsystem auf, aus dem wir eine Transportgleichung für die Zellverteilung auf der Mesoskala, und schließlich eine makroskopische Beschreibung der Zelldichte herleiten. Im Hauptteil der Arbeit entwickeln und analysieren wir geeignete numerische Methoden für das Transportmodell für Gliomenausbreitung und den Übergang zu dessen makroskopischen Grenzwert

    Hands-on Practical Hybrid Parallel Application Performance Engineering

    No full text
    This tutorial presents state-of-the-art performance tools for leading-edge HPC systems founded on the community-developed Score-P instrumentation and measurement infrastructure, demonstrating how they can be used for performance engineering of effective scientific applications based on standard MPI, OpenMP, hybrid combination of both, and increasingly common usage of accelerators. Parallel performance tools from the Virtual Institute – High Productivity Supercomputing (VI-HPS) are introduced and featured in hands-on exercises with Score-P, Scalasca, Vampir, and TAU. We present the complete workflow of performance engineering, including instrumentation, measurement (profiling and tracing, timing and PAPI hardware counters), data storage, analysis, tuning, and visualization. Emphasis is placed on how tools are used in combination for identifying performance problems and investigating optimization alternatives. Using their own notebook computers, participants will conduct exercises on a contemporary HPC system where remote access will be provided for the hands-on sessions through AWS running an E4S [http://e4s.io] image containing all of the necessary tools. This will help to prepare participants to locate and diagnose performance bottlenecks in their own parallel programs
    corecore