Barefoot running improves economy at high intensities and peak treadmill velocity

Aim: Barefoot running can improve running economy (RE) compared to shod running at low exercise intensities, but data is lacking for the higher intensities typical during many distance running competitions. The influence of barefoot running on the velocity at maximal oxygen uptake (vVO2max) and peak incremental treadmill test velocity (vmax) is unknown. The present study tested the hypotheses that barefoot running would improve RE, vVO2max and vmax relative to shod running. Methods: Using a balanced within-subject repeated measures design, eight male runners (aged 23.1±4.5 years, height 1.80±0.06 m, mass 73.8±11.5 kg, VO2max 4.08±0.39 L·min-1) completed a familiarization followed by one barefoot and one shod treadmill running trial, 2-14 days apart. Trial sessions consisted of a 5 minute warm-up, 5 minute rest, followed by 4×4 minute stages, at speeds corresponding to ~67, 75, 84 and 91% shod VO2max respectively, separated by a 1 minute rest. After the 4th stage treadmill speed was incremented by 0.1 km·h-1 every 15 s until participants reached volitional exhaustion. Results: RE was improved by 4.4±7.0% across intensities in the barefoot condition (P=0.040). The improvement in RE was related to removed shoe mass (r2=0.80, P=0.003) with an intercept at 0% improvement for RE at 0.520 kg total shoe mass. Both vVO2max (by 4.5±5.0%, P=0.048) and vmax (by 3.9±4.0%, P=0.030) also improved but VO2max was unchanged (p=0.747). Conclusion: Barefoot running improves RE at high exercise intensities and increases vVO2max and vmax, but further research is required to clarify the influence of very light shoe weights on RE

Regulating Compensation for Injuries Associated with Medical Error

Tort-based system of compensation for injuries associated with medical error is inadequate - development of innovative approaches to no-fault compensation - proposed model of compensation based on the idea of institutions integrating rights-to-claim compensation with regulatory strategies to improve patient safety

Constraints on Cosmological Parameters from the 500 deg² SPTPOL Lensing Power Spectrum

We present cosmological constraints based on the cosmic microwave background (CMB) lensing potential power spectrum measurement from the recent 500 deg² SPTPOL survey, the most precise CMB lensing measurement from the ground to date. We fit a flat ΛCDM model to the reconstructed lensing power spectrum alone and in addition with other data sets: baryon acoustic oscillations (BAO), as well as primary CMB spectra from Planck and SPTPOL. The cosmological constraints based on SPTPOL and Planck lensing band powers are in good agreement when analyzed alone and in combination with Planck full-sky primary CMB data. With weak priors on the baryon density and other parameters, the SPTPOL CMB lensing data alone provide a 4% constraint on σ₈Ω^(0.25)_m = 0.593 ± 0.025. Jointly fitting with BAO data, we find σ₈ = 0.779±0.023, Ω_m = 0.368^(+0.032)_(−0.037), and H₀ = 72.0^(+2.1)_(−2.5)kms⁻¹ Mpc⁻¹, up to 2σ away from the central values preferred by Planck lensing + BAO. However, we recover good agreement between SPTPOL and Planck when restricting the analysis to similar scales. We also consider single-parameter extensions to the flat ΛCDM model. The SPTPOL lensing spectrum constrains the spatial curvature to be Ω_K = −0.0007±0.0025 and the sum of the neutrino masses to be ∑m_ν < 0.23 eV at 95% C.L. (with Planck primary CMB and BAO data), in good agreement with the Planck lensing results. With the differences in the signal-to-noise ratio of the lensing modes and the angular scales covered in the lensing spectra, this analysis represents an important independent check on the full-sky Planck lensing measurement

On the order of vanishing of newforms at cusps

Let $E$ be an elliptic curve over $\mathbb{Q}$ of conductor $N$. We obtain an explicit formula, as a product of local terms, for the ramification index at each cusp of a modular parametrization of $E$ by $X_0(N)$. Our formula shows that the ramification index always divides 24, a fact that had been previously conjectured by Brunault as a result of numerical computations. In fact, we prove a more general result which gives the order of vanishing at each cusp of a holomorphic newform of arbitary level, weight and character, provided its field of rationality satisfies a certain condition. The above result relies on a purely $p$-adic computation of possibly independent interest. Let $F$ be a non-archimedean local field and $\pi$ an irreducible, admissible, generic representation of $\mathrm{GL}_2(F)$. We introduce a new integral invariant, which we call the \emph{vanishing index} and denote $e_\pi(l)$, that measures the degree of "extra vanishing" at matrices of level $l$ of the Whittaker function associated to the newvector of $\pi$. Our main local result writes down the value of $e_\pi(l)$ in every case

Affinity chromatography in dynamic combinatorial libraries: one-pot amplification and isolation of a strongly binding receptor

We report the one-pot amplification and isolation of a nanomolar receptor in a multibuilding block aqueous dynamic combinatorial library using a polymer-bound template. By appropriate choice of a poly(N,N-dimethylacrylamide)-based support, unselective ion-exchange type behaviour between the oppositely charged cationic guest and polyanionic hosts was overcome, such that the selective molecular recognition arising in aqueous solution reactions is manifest also in the analogous templated solid phase DCL syntheses. The ability of a polymer bound template to identify and isolate a synthetic receptor via dynamic combinatorial chemistry was not compromised by the large size of the library, consisting of well over 140 theoretical members, demonstrating the practical advantages of a polymer-supported DCL methodology