Turin, Rome and Genoa: comparison of the level of maturity of three large Italian cities towards Mobility as a Service

Mobility as a Service (MaaS) is the new urban mobility paradigm which, through a digital platform, makes all types of public and private transport services available to users. This contributes to increasing sustainability in cities and the quality of citizens' mobility. However, several factors influence the success of MaaS implementation: openness and data sharing of transport operators; citizens' familiarity and willingness to pay; policy, regulation and legislation; transport services, and infrastructures. Many of these factors are strictly related to the features of the city where MaaS has to operate, and more specifically to its maturity (including multimodality, integration, flexibility, and user-oriented approach). To this end, target users and their willingness to pay for MaaS operations require a specific assessment. This paper compares three large Italian cities - Turin, Rome and Genoa, very different in terms of size, complexity, local transport policies and potential for MaaS application-, with the final goal of outlining common and specific drivers, barriers and requirements for the successful adoption of MaaS. The research findings can provide useful insights to urban mobility decision-makers to avoid the unsuccessful implementation of MaaS, especially when dealing with cities with conservative mobility policies, such as Rome, or where MaaS is a novelty

TEST OF PHYSIOLOGICAL PERFORMANCE: RATIONALE AND FEASIBILITY

Rigorous clinical evaluation of the physiological performance is currently performed with complex and long procedures which need expensive technology and skilled operators. In a wide range of situations (frail patients, daily clinical practice, etc.), these approaches are difficult to be applied and simpler tests, with a lack of scientific background, are mandatory. To avoid these problems, we propose a test (test of physiological performance (TOPP)) to evaluate the physiological behavior of a subject, in a really easy and safe clinical setting, measuring only the heart rate. The subject is submitted to an active standing-up test and then two submaximal exercises (with a low power load) on a cycle-ergometer. The heart rate modifications due to each submaximal step are analyzed by exponential interpolation to calculate the ascending and descending time constants and evaluate the way each subject adapts his heart rate to work. The standard deviation of the RR for each stationary phase (warm-up, load, recovery) was calculated as an index of short-term variability. Then a standard Fourier analysis of the stationary periods of the standing-up procedures allows to quickly and easily evaluate the autonomic nervous activation. We tested the protocol on five healthy subjects to verify the feasibility and the acceptance of the procedure. The five subjects demonstrated a good tolerance of the entire procedure. The standing-up showed a behavior of the autonomic system consistent with the physiology (with an increase in sympathetic activation in the passage to standing position). The analysis of the two submaximal steps highlights how younger and trained subjects present lower heart rates (both in the ascending phase and in the recovery) with a quicker adaptation ability (smaller time constants) consistent with what is expected. The short-term variability of heart rate is greater in young and trained subjects, thus confirming how the sympatho-vagal balance, in these subjects, is more dynamic. The proposed test is well tolerated by the subjects and the results, albeit in a small cohort of healthy volunteers, are consistent with what is expected from physiology and is already present in the literature. Our work aims to be a proposal with a feasibility check of a method for evaluating performance. The work to be done for the clinical validation of the TOPP is still long, but we are aware that it can give important results and that the TOPP can become an effective tool for the assessment of the physiological performance even of fragile subjects

BIOMECHANICAL OPTIMIZATION OF CO2ANGIOGRAPHY

Carbon dioxide (CO2) angiography represents an important technique to overcome most clinical problems related to the use of iodine contrast medium. The recent technologic advancements in the fields of gas injection and image reconstructions made CO2 angiography a very efficient method for clinical evaluation of peripheral cardiovascular system. Despite that, some challenges are still open and a better knowledge of the biomechanical behavior of CO2 and its interactions with blood flowing into the vessels is necessary to optimize this technology and to expand its field of application. This paper presents a quick overview about biomechanical behavior of carbon dioxide during injection, suggesting possible optimization tricks to make CO2 angiography procedures more effective to improve imaging and reduce the patients' radiological dose. Particular attention has been also paid to 3D imaging techniques, which can certainly be opened to the use of carbon dioxide

"Spice", "Kryptonite", "Black Mamba": An overview of brand names and marketing stragtegies of Novel Psychoactive Substances on the Web

Novel Psychoactive Substances (NPSs) are often sold online as “legal” and “safer” alternatives to International Controlled Drugs (ICDs) with captivating marketing strategies. Our aim was to review and summarize such strategies in terms of the appearance of the products, the brand names, and the latest trends in the illicit online marketplaces. Methods: Scientific data were searched in PsychInfo and Pubmed databases; results were integrated with an extensive monitoring of Internet (websites, online shops, chat rooms, fora, social networks) and media sources in nine languages (English, French, Farsi, Portuguese, Arabic, Russian, Spanish, and Chinese simplified/traditional) available from secure databases of the Global Public Health Intelligence Network. Results: Evolving strategies for the online diffusion and the retail of NPSs have been identified, including discounts and periodic offers on chosen products. Advertisements and new brand names have been designed to attract customers, especially young people. An increased number of retailers have been recorded as well as new Web platforms and privacy systems. Discussion: NPSs represent an unprecedented challenge in the field of public health with social, cultural, legal, and political implications.Web monitoring activities are essential for mapping the diffusion of NPSs and for supporting innovative Web-based prevention programmes.Peer reviewedSubmitted Versio

Tannins-Based Extracts: Effects on Gut Chicken Spontaneous Contractility

The impossibility of using drugs for the health of farm animals leads to the search for alternative strategies with two purposes: to maintain animal health and safeguard human health. In this perspective, tannins have shown great promises. These phytocomplexes obtained from natural matrices with multiple health properties may be used as a feed supplement in chicken farms. In this work, we studied two tannin-based extracts (from Castanea sativa Mill. wood and from Schinopsis balansae Engl. Quebracho Colorado hardwood) with different chemical compositions on the spontaneous contractility on the isolated intestinal tissues of healthy chicken. The results showed that the chemical composition of the two phytocomplexes influenced the spontaneous intestinal contractility in different ways by regulating the tone and consequent progression of the food bolus. The chemical analysis of the two extracts revealed that Castanea sativa Mill. wood mainly contains hydrolysable tannins, while Schinopsis balansae Engl. hardwood mainly contains condensed tannins. The two phytocomplexes showed different effects towards gastrointestinal smooth muscle contractility, with Castanea sativa Mill. wood providing a better activity profile than Schinopsis balansae Engl. hardwood

Assessing the Feasibility of MaaS. A Contribution from Three Italian Case Studies

Making all types of public and private transport services available to users through a single and integrated digital platform is the new urban mobility paradigm called Mobility as a Service (MaaS). This scheme allows both a more sustainable urban transportation system and a more effi-cient transport service for users. For MaaS to be successful, its implementation should adapt to the specific features of the location covered by the service. The city maturity level has to be considered in terms of multimodality, infrastructures, regulations, user goals, and user willingness to use and pay for MaaS services. This paper discusses and analyses the results of a survey on MaaS con-ducted in three Italian metropolitan areas: Turin, Rome, and Genoa, which have very different and specific characteristics. The comparative analysis enables the definition of drivers, obstacles, and requisites for MaaS implementation to be successful. When it comes to cities with conservative mobility policies or cities that are new to MaaS experiences, resistance to adoption of the service might occur. The results of the research discussed in this paper can be a useful resource to enable decision makers to develop more effective and efficient transportation policies

Use of the breeding technique to estimate the structure of the analysis 'errors of the day'

A 3D-variational data assimilation scheme for a quasi-geostrophic channel model (Morss, 1998) is used to study the structure of the background error and its relationship to the corresponding bred vectors. The "true" evolution of the model atmosphere is defined by an integration of the model and "rawinsonde observations" are simulated by randomly perturbing the true state at fixed locations. Case studies using different observational densities are considered to compare the evolution of the Bred Vectors to the spatial structure of the background error. In addition, the bred vector dimension (BV-dimension), defined by Patil et al. (2001) is applied to the bred vectors. It is found that after 3-5 days the bred vectors develop well organized structures which are very similar for the two different norms (enstrophy and streamfunction) considered in this paper. When 10 surrogate bred vectors (corresponding to different days from that of the background error) are used to describe the local patterns of the background error, the explained variance is quite high, about 85-88%, indicating that the statistical average properties of the bred vectors represent well those of the background error. However, a subspace of 10 bred vectors corresponding to the time of the background error increased the percentage of explained variance to 96-98%, with the largest percentage when the background errors are large. These results suggest that a statistical basis of bred vectors collected over time can be used to create an effective constant background error covariance for data assimilation with 3D-Var. Including the "errors of the day" through the use of bred vectors corresponding to the background forecast time can bring an additional significant improvement

Effect of high-pass filtering on ECG signal on the analysis of patients prone to atrial fibrillation

The aim of this study was to assess the effect of filtering techniques on the time-domain analysis of the ECG. Multi-lead ECG recordings obtained from chronic atrial fibrillation (AF) patients after successful external cardioversion have been acquired. Several high-pass filtering techniques and three cut-off frequency values were used: Bessel and Butterworth four-pole and two-pole bidirectional and unidirectional filters, at 0.01, 0.05 and 0.5 Hz low cut-off frequency. As a reference, a beat-by-beat linear piecewise interpolation was used to remove baseline wander, on each P-wave. Results show that ECG filtering affects the estimation of P-wave duration in a manner that depends upon the type of filter used: particularly, the bidirectional filters caused negligible variation of P-wave duration, while unidirectional ones provoked an increase higher than 8%

Management of patients with atrial fibrillation: different therapeutic options and role of electrophysiology-guided approaches.

At present the approach to atrial fibrillation treatment is based on the electrophysiological patterns of atrial fibrillation (on the basis of multiple intra-atrial recordings or sophisticated new mapping techniques) only in a restricted minority of patients, those who are candidate to ablation of the substrate and/or of the triggers. Atrial fibrillation has a broad spectrum of clinical presentations and a heterogeneous electrophysiological pattern. The treatment of this arrhythmia, both with drugs and non pharmacological treatments, has been based, classically, on empirical basis and on a clinically-guided staged-approach. The limitations of pharmacological treatment led in recent years to the development of a wide spectrum of non pharmacological treatments. This implies a change in the approach to atrial fibrillation and the need to identify potentially ideal candidates to complex and expensive treatments. In this view it is currently under investigation the possibility to identify potential responders to a definitive treatment or a combination of treatments (both pharmacological and non-pharmacological) on the basis of the electrophysiological pattern