Coupling a distributed grid based hydrological model and MM5 meteorological model for flooding alert mapping

International audienceThe increased number of extreme rainfall events seems to be one of the common feature of climate change signal all over the world (Easterlin et al., 2000; Meehl et al., 2000). In the last few years a large number of floods caused by extreme meteorological events has been observed over the river basins of Mediterranean area and they mainly affected small basins (few hundreds until few thousands of square kilometres of drainage area) . A strategic goal of applied meteorology is now to try to predict with high spatial resolution the segments of drainage network where floods may occur. A possible way to reach this aim is the coupling of meteorological mesoscale model with high resolution hydrological model. In this work few case studies of observed floods in the Italian Mediterranean area will be presented. It is shown how a distributed hydrological model, using the precipitation fields predicted by MM5 meteorological model, is able to highlight the area where the major floods may occur

Alkali-activation of aggregate fines from construction and demolition waste: valorisation in view of road pavement subbase applications

This study investigates the potential of fine particles of recycled construction and demolition waste (CDW) aggregate to undergo alkali-activation when mixed with an appropriate alkaline solution. The fine is a natural by-product of the milling process and includes particles from four main material sources (i.e., recycled concrete, recycled asphalt, crushed bricks and tiles, and natural aggregate and excavated soil) and other occasional elements which are too small for identification. The fine was obtained by sifting the material through a 125 μm sieve. Since the reactivity of unselected material depends on its constituents, these were also individually investigated. Firstly, the four constituents of CDW recycled aggregates were separated, then milled to a size smaller than 125 μm, before being tested to measure their reactivity to an alkaline solution. A preliminary chemical and mineralogical characterization of the five powders was carried out to identify the main crystalline phases and ascertain the presence of aluminosilicates needed for the alkali activation process. Particles of each powder were afterwards mixed with three concentrations of the same alkaline solution with a liquid/solid mass ratio of 0.4, cast in prismatic moulds, and cured at room temperature. Mechanical tests after 3, 7, and 28 days of curing demonstrated that powders react positively in a basic environment, showing an increase in strength without any thermal treatment. Hardened pastes of undivided fine aggregate and recycled asphalt exhibited the best results in terms of flexural and compressive strength with the more concentrated solution. A Field Emission Scanning Electron Microscopy analysis was also carried out to observe the microstructure and to support an interpretation of the mechanical strength data. Results demonstrated the feasibility of using a solution to activate unselected CDW fine particles to stabilize CDW aggregates. In full scale applications, CDW aggregates can be stabilized without the addition of any binder

Effect of Degradation on Mechanical Strengths of Alkali-Activated Fines in Stabilized Construction and Demolition Waste Aggregates

Recent works have demonstrated that construction and demolition waste (CDW) aggregates for subbase road pavement applications can be stabilized via the alkali activation of their fine fraction (d<0.125 mm). Despite the promising results with this method, the durability of alkali-activated (AA) CDW fines (which act to stabilize CDW aggregate mixtures) need to be investigated. To this end, the effects on pavement materials of the typical degrading actions of water, deicing salts, and the freeze-thaw process were investigated. Samples of AA fines were subjected to water, deicing salt, and freeze-thaw treatments and assessed based on the variation in 28-day flexural and compressive strength values with respect to not-degraded materials. In addition to the fines normally present in CDW aggregate mixtures (i.e., the undivided fraction), samples with fines of the main CDW constituents (concrete, asphalt, bricks and tiles, aggregates and soil) were also prepared for comparison purposes. One set of specimens was cured at 20°C to replicate field conditions, and another was treated at 80°C to replicate optimal conditions for AA materials. Although 80°C heat-treated specimens achieved higher strength values, those values fell sharply following the degrading action of water and deicing salts. In contrast, the specimens cured at 20°C retained their mechanical property values even after exposure to water and deicing salt degradations

Alkali-activation of marble sludge: Influence of curing conditions and waste glass addition

The use of marble sludge as precursor for new alkali activated materials was assessed studying three different curing conditions (air, humid and water immersion, respectively), after an initial curing at 60 °C for 24 h, and two glass powder fractions additions (2.5 and 5.0 vol%). Microstructural, physical (drying shrinkage, Fourier transform-infrared (FT-IR) spectroscopy, X-ray spectroscopy (XPS)), thermal (differential thermal analysis – thermogravimetric analysis, DTA-TGA) and mechanical (flexural and compressive strength) properties were investigated. Air curing was the most favourable atmosphere for mechanical properties development because it promotes Si-O-Si polymerization and gel densification, as demonstrated by FT-IR and FE-SEM observations, respectively. Satisfactory mechanical properties were achieved (18 MPa and 45 MPa, for flexural and compressive strength, respectively) in particular for glass containing mixtures. Moreover, glass powder addition significantly reduced drying shrinkage of air-cured samples because it operated as a rigid aggregate in the matrix and strengthened the formed gel

Role of natural stone wastes and minerals in the Alkali activation process: A review

This review aims to provide a comprehensive assessment concerning alkali activation of natural stone wastes and minerals. In particular, the structure of the review is divided into two main sections in which the works dealing with alumino-silicate and carbonatic stones are discussed, respectively. Alumino-silicate stones are generally composed of quartz and feldspars, while carbonatic stones are mainly made of calcite and dolomite. The role of these minerals in the alkali activation process is discussed, attesting their influence in the development of the final product properties. In most of the works, authors use mineral additions only as fillers or aggregates and, in some cases, as a partial substitution of more traditional raw powders, such as metakaolin, fly ash, and granulated blast furnace slag. However, a few works in which alumino-silicate and carbonatic stone wastes are used as the main active components are discussed as well. Not only the raw materials, but also the entire alkali activation process and the curing conditions adopted in the literature studies here reviewed are systematically analyzed to improve the understanding of their effect on the physical, mechanical, and durability properties of the final products and to eventually foster the reuse of natural stone wastes for the purposes of sustainability in different applications

Increased Perfusion and Angiogenesis in a Hindlimb Ischemia Model with Plasmid FGF-2 Delivered by Noninvasive Electroporation

Gene therapy approaches delivering fibroblast growth factor-2 (FGF-2) have shown promise as a potential treatment for increasing blood flow to ischemic limbs. Currently, effective noninvasive techniques to deliver plasmids encoding genes of therapeutic interest, such as FGF-2, are limited. We sought to determine if intradermal injection of plasmid DNA encoding FGF-2 (pFGF) followed by noninvasive cutaneous electroporation (pFGFE+) could increase blood flow and angiogenesis in a rat model of hindlimb ischemia. pFGFE+ or control treatments were administered on postoperative day 0. Compared to injection of pFGF alone (pFGFE-), delivery of pFGFE+ significantly increased FGF-2 expression for 10 days. Further, the increase in FGF-2 expression with pFGFE+ was sufficient to significantly increase ischemic limb blood flow, measured by laser Doppler perfusion imaging, beginning on postoperative day 3. Ischemic limb blood flow in the pFGFE+ treatment group remained significantly higher than all control groups through the end point of the study, postoperative day 14. Immunohistochemical staining of gastrocnemius cross sections determined there was a twofold increase in capillary density in the pFGFE+ treatment group. Our results suggest that pFGFE+ is a potential noninvasive, nonviral therapeutic approach to increase perfusion and angiogenesis for the treatment of limb ischemia

Thermally driven circulation in a region of complex topography: comparison of wind-profiling radar measurements and MM5 numerical predictions

The diurnal variation of regional wind patterns in the complex terrain of Central Italy was investigated for summer fair-weather conditions and winter time periods using a radar wind profiler. The profiler is located on a site where interaction between the complex topography and land-surface produces a variety of thermally and dynamically driven wind systems. The observational data set, collected for a period of one year, was used first to describe the diurnal evolution of thermal driven winds, second to validate the Mesoscale Model&amp;nbsp;5 (MM5) that is a three-dimensional numerical model. This type of analysis was focused on the near-surface wind observation, since thermally driven winds occur in the lower atmosphere. According to the valley wind theory expectations, the site &amp;ndash; located on the left sidewall of the valley (looking up valley) &amp;ndash; experiences a clockwise turning with time. Same characteristics in the behavior were established in both the experimental and numerical results. &lt;P style=&quot;line-height: 20px;&quot;&gt; Because the thermally driven flows can have some depth and may be influenced mainly by model errors, as a third step the analysis focuses on a subset of cases to explore four different MM5 Planetary Boundary Layer (PBL) parameterizations. The reason is to test how the results are sensitive to the selected PBL parameterization, and to identify the better parameterization if it is possible. For this purpose we analysed the MM5 output for the whole PBL levels. The chosen PBL parameterizations are: 1) Gayno-Seaman; 2) Medium-Range Forecast; 3) Mellor-Yamada scheme as used in the ETA model; and 4) Blackadar

Evidence for mTOR pathway activation in a spectrum of epilepsy-associated pathologies

Introduction Activation of the mTOR pathway has been linked to the cytopathology and epileptogenicity of malformations, specifically Focal Cortical Dysplasia (FCD) and Tuberous Sclerosis (TSC). Experimental and clinical trials have shown than mTOR inhibitors have anti-epileptogenic effects in TS. Dysmorphic neurones and balloon cells are hallmarks of FCDIIb and TSC, but similar cells are also occasionally observed in other acquired epileptogenic pathologies, including hippocampal sclerosis (HS) and Rasmussen’s encephalitis (RE). Our aim was to explore mTOR pathway activation in a range of epilepsy-associated pathologies and in lesion-negative cases. Results 50 epilepsy surgical pathologies were selected including HS ILAE type 1 with (5) and without dysmorphic neurones (4), FCDIIa (1), FCDIIb (5), FCDIIIa (5), FCDIIIb (3), FCDIIId (3), RE (5) and cortex adjacent to cavernoma (1). We also included pathology-negative epilepsy cases; temporal cortex (7), frontal cortex (2), paired frontal cortical samples with different ictal activity according to intracranial EEG recordings (4), cortex with acute injuries from electrode tracks (5) and additionally non-epilepsy surgical controls (3). Immunohistochemistry for phospho-S6 (pS6) ser240/244 and ser235/236 and double-labelling for Iba1, neurofilament, GFAP, GFAPdelta, doublecortin, and nestin were performed. Predominant neuronal labelling was observed with pS6 ser240/244 and glial labelling with pS6 ser235/236 in all pathology types but with evidence for co-expression in a proportion of cells in all pathologies. Intense labelling of dysmorphic neurones and balloon cells was observed in FCDIIb, but dysmorphic neurones were also labelled in RE and HS. There was no difference in pS6 labelling in paired samples according to ictal activity. Double-labelling immunofluorescent studies further demonstrated the co-localisation of pS6 with nestin, doublecortin, GFAPdelta in populations of small, immature neuroglial cells in a range of epilepsy pathologies. Conclusions Although mTOR activation has been more studied in the FCDIIb and TSC, our observations suggest this pathway is activated in a variety of epilepsy-associated pathologies, and in varied cell types including dysmorphic neurones, microglia and immature cell types. There was no definite evidence from our studies to suggest that pS6 expression is directly related to disease activity

The Carina Project. VI. The helium burning variable stars

We present new optical (BVI) time-series data for the evolved variable stars in the Carina dwarf spheroidal galaxy. The quality of the data and the observing strategy allowed us to identify 14 new variable stars. Eight out of the 14 are RR Lyrae (RRL) stars, four are Anomalous Cepheids (ACs) and two are geometrical variables. Comparison of the period distribution for the entire sample of RRLs with similar distributions in nearby dSphs and in the Large Magellanic Cloud indicates that the old stellar populations in these systems share similar properties. This finding is also supported by the RRL distribution in the Bailey diagram. On the other hand, the period distribution and the Bailey diagram of ACs display significant differences among the above stellar systems. This evidence suggests that the properties of intermediate-age stellar populations might be affected both by environmental effects and structural parameters. We use the BV Period--Wesenheit (PW) relation of RRLs together with evolutionary prescriptions and find a true distance modulus of 20.09+/-0.07(intrinsic)+/-0.1(statistical) mag that agrees quite well with similar estimates available in the literature. We identified four peculiar variables. Taking into account their position in the Bailey diagram and in the BV PW relation, two of them (V14, V149) appear to be candidate ACs, while two (V158, V182) might be peculiar RRLs. In particular, the variable V158 has a period and a V-band amplitude very similar to the low-mass RRL ---RRLR-02792---recently identified by Pietrzynski at al. (2012) in the Galactic bulge.Comment: Accepted for publication in ApJ, publication date September 20, 2013. 31 pages, 7 figure, 3 tables. Figs. 3 and 4 corrected, references added, minor correction