1,374 research outputs found
Inadequate cancer screening: Lack of provider continuity is a greater obstacle than medical mistrust
Socio-Dramatic Play as a Vehicle for Curriculum Integration in First Grade
A brief narrative description of the journal article, document, or resource. Describes how the sociodramatic play experiences of a group of first graders served as a vehicle for integrating the classroom curriculum. Considers play as a curricular tool and adults\u27 roles in sociodramatic play. Shows how first-graders\u27 play in connection with creating a card shop incorporated reading, writing, and mathematical skills, and provided opportunities for peer collaboration and teaching. (KB
Berthing of Space Station Freedom using the shuttle remote manipulator system
A large-angle, flexible, multi-body, dynamic modeling capability was developed to help validate analytical simulations of the dynamic motion and control forces which occur while berthing of Space Station Freedom to the Shuttle Orbiter during early assembly flights. The dynamics and control of the station, the attached Shuttle Remote Manipulator System, and the Orbiter during a berthing maneuver are described. Emphasis is placed on the modeling of the Shuttle Remote Manipulator System in the multi-body simulation. The influence of the elastic behavior of the station and of the Remote Manipulator System on the attitude control of the station/Orbiter system during the maneuver is investigated
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Large-effect flowering time mutations reveal conditionally adaptive paths through fitness landscapes in Arabidopsis thaliana.
Contrary to previous assumptions that most mutations are deleterious, there is increasing evidence for persistence of large-effect mutations in natural populations. A possible explanation for these observations is that mutant phenotypes and fitness may depend upon the specific environmental conditions to which a mutant is exposed. Here, we tested this hypothesis by growing large-effect flowering time mutants of Arabidopsis thaliana in multiple field sites and seasons to quantify their fitness effects in realistic natural conditions. By constructing environment-specific fitness landscapes based on flowering time and branching architecture, we observed that a subset of mutations increased fitness, but only in specific environments. These mutations increased fitness via different paths: through shifting flowering time, branching, or both. Branching was under stronger selection, but flowering time was more genetically variable, pointing to the importance of indirect selection on mutations through their pleiotropic effects on multiple phenotypes. Finally, mutations in hub genes with greater connectedness in their regulatory networks had greater effects on both phenotypes and fitness. Together, these findings indicate that large-effect mutations may persist in populations because they influence traits that are adaptive only under specific environmental conditions. Understanding their evolutionary dynamics therefore requires measuring their effects in multiple natural environments
The Nebraska Mesonet: Technical Overview of an Automated State Weather Network
The Nebraska Mesonet was established in 1981 as one of the nation’s first automated state weather networks. ‘‘Automated’’ is defined by the nature of the observations being made and recorded by machine, as opposed to observations made and recorded manually. At the time of inception, the five observing locations were geared toward servicing agricultural production applications. The Nebraska Mesonet has grown to 69 stations (as of 2018) and is now a multipurpose environmental observing network under the Nebraska State Climate Office (NSCO). The network is composed of environmental observation stations, sited using best practices for mesoscale and microscale environment situations. Precise observations are acquired using highquality instrumentation, following manufacturer recommendations for calibrations and maintenance. Calibrations are performed in the NSCO calibration laboratory. Uses for the data include but are not limited to water management, drought monitoring, energy production, health, environmental research, animal management, and crop pest management. This paper provides a technical overview and history of the network, outlining current practices for station siting, maintenance, data quality assurance, and data utility
Maternal Geohelminth Infections Are Associated with an Increased Susceptibility to Geohelminth Infection in Children: A Case-Control Study
Background: Children of mothers infected with soil-transmitted helminths (STH) may have an increased susceptibility to STH infection.
Methods and Findings: We did a case-control study nested in a birth cohort in Ecuador. Data from 1,004 children aged 7
months to 3 years were analyzed. Cases were defined as children with Ascaris lumbricoides and/or Trichuris trichiura, controls without. Exposure was defined as maternal infection with A. lumbricoides and/or T. trichiura, detected during the third
trimester of pregnancy. The analysis was restricted to households with a documented infection to control for infection risk. Children of mothers with STH infections had a greater risk of infection compared to children of uninfected mothers (adjusted OR 2.61, 95% CI: 1.88–3.63, p,0.001). This effect was particularly strong in children of mothers with both STH infections (adjusted OR: 5.91, 95% CI: 3.55–9.81, p,0.001). Newborns of infected mothers had greater levels of plasma IL-10 than those of uninfected mothers (p = 0.033), and there was evidence that cord blood IL-10 was increased among newborns who became infected later in childhood (p = 0.060).
Conclusion: Our data suggest that maternal STH infections increase susceptibility to infection during early childhood, an effect that was associated with elevated IL-10 in cord plasma
Modeling Biological Membranes with Circuit Boards and Measuring Electrical Signals in Axons: Student Laboratory Exercises
This is a demonstration of how electrical models can be used to characterize biological membranes. This exercise also introduces biophysical terminology used in electrophysiology. The same equipment is used in the membrane model as on live preparations. Some properties of an isolated nerve cord are investigated: nerve action potentials, recruitment of neurons, and responsiveness of the nerve cord to environmental factors
Keys to successful balanced scorecard implementation and use based on published implementation attempts
In recent years many companies have evolved from being centrally located and managed to decentralized, multi-national companies consisting of many separate entities to be strategically managed. In response to this and other changes, such as the need for better measurement of performance, a strategic management tool was developed called the Balanced Scorecard (BSC). This research provides a tool to guide and evaluate BSC implementation. A meta-synthesis approach was used to examine qualitative BSC data available in the literature that suggested eleven keys to successful BSC implementation and use. These keys are then used to benchmark an implementation in a government logistics organization
What is an address in South Africa?
Addresses come in many forms as they have a variety of uses. In our paper we illustrate the need for standardized addresses in South Africa by describing scenarios where standardized addresses are required, or where standardized addresses would improve the current situation. We present the eleven address types described in the current draft South African address standard (SANS 1883), which has been developed under the auspices of the South African Bureau of Standards. We go on to show that these address types represent an all-encompassing description of an address in South Africa. The address types have to accommodate the current situation where there are no mandated authorities that assign standardized addresses according to a set of guidelines, and we provide a critical evaluation of this situation. Our contribution is threefold: illustrating the need for standardized addresses, showing that there is an all-encompassing description for an address in South Africa, and describing the potential negative impact of the current lack of mandated authorities on unambiguous address specification and the benefits that address standardization would bring.http://www.sajs.co.za
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