U.S. Foreign Trade in Services: Trends and U.S. Policy Challenges

[Excerpt] This report provides background information and analysis on U.S. foreign trade in services. The focus of the report is an analysis of the policy challenges that the United States confronts, especially the challenge of negotiating a set of international disciplines on trade in services and dealing with the complexity of measuring trade in services. The report also focuses on emerging issues and current negotiations, especially those pertaining to the Trade in Services Agreement (TISA), the Trans-Pacific Partnership (TPP), and the Transatlantic Trade and Investment Partnership (TTIP) agreement

The Future Role of U.S. Trade Policy: An Overview

[Excerpt] The United States has become increasingly integrated with the rest of the world economy. This integration has offered benefits and presented challenges to U.S. business, agriculture, labor, and consumers. Those who can compete in the more integrated economy have enjoyed opportunities to broaden their success, while those who are challenged by increased foreign competition have been forced to adjust and some have exited the market or relocated overseas. Some observers contend that, in order to remain globally competitive, the United States must continue to support trade liberalization policies, while assisting those hurt by trade. Others have raised doubts over whether free trade policies benefit the U.S. economy (e.g., some blame such policies for the large U.S. trade deficit, declining wages, and growing income disparity). Many contend that trade liberalization works only when everyone plays by the rules and have urged the aggressive enforcement of U.S. trade laws to address unfair trade practices. Still others maintain that such issues as labor rights, the environment, and climate change should be linked to trade policies. These competing views are often reflected in the struggle between Congress and the Executive branch in shaping U.S. trade policy. This report provides an overview and background on the debate over the future course of U.S. trade policy and will be updated as events warrant

A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome

DNA topoisomerases are required to resolve DNA topological stress. Despite this essential role, abortive topoisomerase activity generates aberrant protein-linked DNA breaks, jeopardising genome stability. Here, to understand the genomic distribution and mechanisms underpinning topoisomerase-induced DNA breaks, we map Top2 DNA cleavage with strand-specific nucleotide resolution across the S. cerevisiae and human genomes—and use the meiotic Spo11 protein to validate the broad applicability of this method to explore the role of diverse topoisomerase family members. Our data characterises Mre11-dependent repair in yeast and defines two strikingly different fractions of Top2 activity in humans: tightly localised CTCF-proximal, and broadly distributed transcription-proximal, the latter correlated with gene length and expression. Moreover, single nucleotide accuracy reveals the influence primary DNA sequence has upon Top2 cleavage—distinguishing sites likely to form canonical DNA double-strand breaks (DSBs) from those predisposed to form strand-biased DNA single-strand breaks (SSBs) induced by etoposide (VP16) in vivo

The model area in successful lean transformation and scale modeling

The True Lean System Program at the University of Kentucky was created in 1994 to study how the development of the Toyota Production System (TPS) contributes to Toyota’s success. This increased understanding of Toyota’s experience would provide useful guidance to Western companies taking on the challenges of replicating Toyota’s success within their own organizations. The common struggle point shared by the companies who come to us is their inability to establish sustainable TPS-based Lean transformations throughout their organizations. Our work with these companies along with our study of Toyota’s own experience in bringing TPS to its own American operations has led to a belief that a major obstacle to adopting and implementing TPS into Western organizations is a lack of understanding of the essential motivational mechanisms embodied in TPS. It was these motivational factors that originally triggered the creativity and innovation of Toyota’s workforce in the context of Japanese culture. In bringing TPS to America, Fujio Cho recognized the need to pay attention to these same motivational factors with an American workforce, particularly in light of the fundamental cultural differences between Toyota’s Japanese workforce and their Western counterparts. This TPS-cultural difference needs to be clearly understood to enable Western companies to successfully transform into TPS-driven organizations. TPS is based on a learning-by-doing methodology which has lent itself to a transformative process in which organizations apply the principles of TPS and kaizen in a limited model area before spreading to the entire organization. The result of this application produces a series of incremental (often small) improvements which may be explained with the help of scale modeling principles and methodology. This paper is our first attempt to show the direct applicability of scale modeling concepts/methodology to the model area approach for successful TPS transformation, including the role of standardization and problem solving in Kaizen. i.e. continuous improvement. Our new findings show promising first steps for organizations and TPS/Lean researchers facing the twin challenges of establishing sustainable TPS/Lean models and subsequently scaling them up along a pathway defined by the needs to achieve full scale TPS/Lean organizational transformations

The effect of host structure on the selectivity and mechanism of supramolecular catalysis of Prins cyclizations.

The effect of host structure on the selectivity and mechanism of intramolecular Prins reactions is evaluated using K12Ga4L6 tetrahedral catalysts. The host structure was varied by modifying the structure of the chelating moieties and the size of the aromatic spacers. While variation in chelator substituents was generally observed to affect changes in rate but not selectivity, changing the host spacer afforded differences in efficiency and product diastereoselectivity. An extremely high number of turnovers (up to 840) was observed. Maximum rate accelerations were measured to be on the order of 105, which numbers among the largest magnitudes of transition state stabilization measured with a synthetic host-catalyst. Host/guest size effects were observed to play an important role in host-mediated enantioselectivity

Is Social Media a Threat or Can It Be a Trusted Agent?

There is a prevailing belief within the United States Department of Defense (DOD) that social media is a threat to national security, leading to restrictions in workplace use of social-media applications. However, instead of dismissing social media as a threat, leaders should be asking whether or not the information received via social media can be trusted, thus leveraging the information-sharing capabilities of social media. This article presents a theoretical case for quantifying social media trustworthiness by exploring the factors that influence trust in social media and proposing a trust framework to be used to quantify trustworthiness

The virtual Haken conjecture: Experiments and examples

A 3-manifold is Haken if it contains a topologically essential surface. The Virtual Haken Conjecture says that every irreducible 3-manifold with infinite fundamental group has a finite cover which is Haken. Here, we discuss two interrelated topics concerning this conjecture. First, we describe computer experiments which give strong evidence that the Virtual Haken Conjecture is true for hyperbolic 3-manifolds. We took the complete Hodgson-Weeks census of 10,986 small-volume closed hyperbolic 3-manifolds, and for each of them found finite covers which are Haken. There are interesting and unexplained patterns in the data which may lead to a better understanding of this problem. Second, we discuss a method for transferring the virtual Haken property under Dehn filling. In particular, we show that if a 3-manifold with torus boundary has a Seifert fibered Dehn filling with hyperbolic base orbifold, then most of the Dehn filled manifolds are virtually Haken. We use this to show that every non-trivial Dehn surgery on the figure-8 knot is virtually Haken.Comment: Published by Geometry and Topology at http://www.maths.warwick.ac.uk/gt/GTVol7/paper12.abs.htm

Technical Challenges Associated with In-Air Wingtip Docking of Aircraft in Forward Flight

Autonomous in-air wingtip docking of aircraft offers significant opportunity for system level performance gains for numerous aircraft applications. Several of the technical challenges facing wingtip docking of fixed-wing aircraft are addressed in this paper, including: close proximity aerodynamic coupling; mechanisms and operations for robust docking; and relative state estimation methods. A simulation framework considering the aerodynamics, rigid-body dynamics, and vehicle controls is developed and used to perform docking sensitivity studies for a system of two 5.5% scale NASA Generic Transport Model aircraft. Additionally, proof of- concept testing of a candidate docking mechanism designed to move the primary wingtip vortex inboard suggests the viability of such an approach for achieving robust docking