7,157 research outputs found
Chaos in Time Dependent Variational Approximations to Quantum Dynamics
Dynamical chaos has recently been shown to exist in the Gaussian
approximation in quantum mechanics and in the self-consistent mean field
approach to studying the dynamics of quantum fields. In this study, we first
show that any variational approximation to the dynamics of a quantum system
based on the Dirac action principle leads to a classical Hamiltonian dynamics
for the variational parameters. Since this Hamiltonian is generically nonlinear
and nonintegrable, the dynamics thus generated can be chaotic, in distinction
to the exact quantum evolution. We then restrict attention to a system of two
biquadratically coupled quantum oscillators and study two variational schemes,
the leading order large N (four canonical variables) and Hartree (six canonical
variables) approximations. The chaos seen in the approximate dynamics is an
artifact of the approximations: this is demonstrated by the fact that its onset
occurs on the same characteristic time scale as the breakdown of the
approximations when compared to numerical solutions of the time-dependent
Schrodinger equation.Comment: 10 pages (12 figures), RevTeX (plus macro), uses epsf, minor typos
correcte
Histological and immunocytological changes in psoriasis after 7 days of cyclosporin therapy
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75545/1/j.1365-2133.1987.tb12012.x.pd
Sweetening of Glutamine Metabolism in Cancer Cells by Rho GTPases Through Convergence of Multiple Oncogenic Signaling Pathways
Comment on: Lukey MJ, Greene KS, Erickson JW, et al. The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy. Nat Commun 2016;7:11321
Observation of Motion Dependent Nonlinear Dispersion with Narrow Linewidth Atoms in an Optical Cavity
As an alternative to state-of-the-art laser frequency stabilisation using
ultra-stable cavities, it has been proposed to exploit the non-linear effects
from coupling of atoms with a narrow transition to an optical cavity. Here we
have constructed such a system and observed non-linear phase shifts of a narrow
optical line by strong coupling of a sample of strontium-88 atoms to an optical
cavity. The sample temperature of a few mK provides a domain where the Doppler
energy scale is several orders of magnitude larger than the narrow linewidth of
the optical transition. This makes the system sensitive to velocity dependent
multi-photon scattering events (Dopplerons) that affect the cavity field
transmission and phase. By varying the number of atoms and the intra-cavity
power we systematically study this non-linear phase signature which displays
roughly the same features as for much lower temperature samples. This
demonstration in a relatively simple system opens new possibilities for
alternative routes to laser stabilization at the sub 100 mHz level and
superradiant laser sources involving narrow line atoms. The understanding of
relevant motional effects obtained here has direct implications for other
atomic clocks when used in relation with ultranarrow clock transitions.Comment: 9 pages (including 4 pages of Supplemental Information), 6 figures.
Updated to correspond to the published versio
A Survey of Oxidative Paracatalytic Reactions Catalyzed by Enzymes That Generate Carbanionic Intermediates: Implications for ROS Production, Cancer Etiology, and Neurodegenerative Diseases
Enzymes that generate carbanionic intermediates often catalyze paracatalytic reactions with O2 and other electrophiles not considered “normal” reactants. For example, pyridoxal 5′-phosphate (PLP)—containing pig kidney dopa decarboxylase oxidizes dopamine with molecular O2 to 3,4-dihydroxyphenylacetaldehyde at about 1% of the rate at which it catalyzes nonoxidative dopa decarboxylation. The mutant Y332F enzyme, however, catalyzes stoichiometric conversion of dopa to 3,4-dihydroxyphenylacetaldehyde, suggesting that even minor structural changes may alter or initiate paracatalytic reactions catalyzed by certain enzymes. Carbanions generated by several thiamine diphosphate (ThDP)—dependent enzymes react with different electrophiles, transforming some xenobiotics and endogenous compounds into potentially biologically hazardous products. The detrimental effects of paracatalytic reactions may be greatly increased by cellular compartmentation of enzymes and intermediates. For example, in two of the the three multienzyme complexes involved in oxidative α-keto acid decarboxylation, paracatalytic reactions of the third component inactivate the first carbanion-generating component. In this review we provide an outline of carbanion-generating enzymes known to catalyze paracatalytic reactions. We also discuss the potential of some of these reactions to contribute to irreversible damage in cancer and neurodegeneration through disease-induced alterations in the metabolic state and/or protein structure
Cystamine and Cysteamine As Inhibitors of Transglutaminases In Vivo
Cystamine is commonly used as a transglutaminase inhibitor. This disulfide undergoes reduction in vivo to the aminothiol compound, cysteamine. Thus, the mechanism by which cystamine inhibits transglutaminase activity in vivo could be due to either cystamine or cysteamine, which depends on the local redox environment. Cystamine inactivates transglutaminases by promoting the oxidation of two vicinal cysteine residues on the enzyme to an allosteric disulfide, whereas cysteamine acts as a competitive inhibitor for transamidation reaction catalyzed by this enzyme. The latter mechanism is likely to result in the formation of a unique biomarker, N -(gamma-glutamyl)cysteamine that could serve to indicate how cyst(e)amine acts to inhibit transglutaminases inside cells and the body
A novel mode of capping protein-regulation by Twinfilin
Cellular actin assembly is controlled at the barbed ends of actin filaments, where capping protein (CP) limits polymerization. Twinfilin is a conserved in vivo binding partner of CP, yet the significance of this interaction has remained a mystery. Here, we discover that the C-terminal tail of Twinfilin harbors a CP-interacting (CPI) motif, identifying it as a novel CPI-motif protein. Twinfilin and the CPI-motif protein CARMIL have overlapping binding sites on CP. Further, Twinfilin binds competitively with CARMIL to CP, protecting CP from barbed-end displacement by CARMIL. Twinfilin also accelerates dissociation of the CP inhibitor V-1, restoring CP to an active capping state. Knockdowns of Twinfilin and CP each cause similar defects in cell morphology, and elevated Twinfilin expression rescues defects caused by CARMIL hyperactivity. Together, these observations define Twinfilin as the first \u27pro-capping\u27 ligand of CP and lead us to propose important revisions to our understanding of the CP regulatory cycle
Adiabatic Control of Decoherence-Free-Subspaces in an Open Collective System
We propose a method to adiabatically control an atomic ensemble using a
decoherence-free subspace (DFS) within a dissipative cavity. We can engineer a
specific eigenstate of the system's Lindblad jump operators by injecting a
field into the cavity which deconstructively interferes with the emission
amplitude of the ensemble. In contrast to previous adiabatic DFS proposals, our
scheme creates a DFS in the presence of collective decoherence. We therefore
have the ability to engineer states that have high multi-particle entanglements
which may be exploited for quantum information science or metrology. We further
demonstrate a more optimized driving scheme that utilizes the knowledge of
possible diabatic evolution gained from the so-called adiabatic criteria. This
allows us to evolve to a desired state with exceptionally high fidelity on a
time scale that does not depend on the number of atoms in the ensemble. By
engineering the DFS eigenstate adiabatically, our method allows for faster
state preparation than previous schemes that rely on damping into a desired
state solely using dissipation.Comment: 15 pages and 8 Figure
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