Shuttle orbiter radar cross-sectional analysis

Theoretical and model simulation studies on signal to noise levels and shuttle radar cross section are described. Pre-mission system calibrations, system configuration, and postmission system calibration of the tracking radars are described. Conversion of target range, azimuth, and elevation into radar centered east north vertical position coordinates are evaluated. The location of the impinging rf energy with respect to the target vehicles body axis triad is calculated. Cross section correlation between the two radars is presented

The impact of Proposal A on two Michigan school districts

In 1994 the state of Michigan changed its school finance system. Over a nine-month period between July, 1993, and March, 1994, state legislators and the voters of Michigan acted to change the tax structure and address funding equity for public schools. In the fall of 1994, Michigan’s public schools began operating under an entirely new set of school finance reforms. The primary focus of this research is the articulation of the effects of the 1994 Michigan school funding reform (Proposal A). The purpose of this research was to conduct a policy analysis and impact analysis of Proposal A on two Michigan school districts. The research, which is drawn from Thompson (1967) and Pfeffer & Salancik (2003), traced the relationship between environment and governance actions as it pertained to fund allocation in the K-12 Michigan school system. A case study design with a qualitative emphasis was chosen as the structure of this research. The research centered upon the formulation and instrumentation of organizational changes for two northern lower Michigan school districts, as they occurred, as well as the results of those changes. Research focused around data which consisted of interviews, observational notes, state and local documents, and other artifacts. The initial focus was upon the events leading to Proposal A and why these factors necessitated change. Those data are followed by a review of the relationship between fiscal federalism, governance, and resource dependency theory and application of those findings to data relevant to the two districts in northern Michigan. This study is unique in its narrowed focus and structural specificity

Developing the Next Generation of Physics Assessments

Science education at all levels is currently undergoing dramatic changes to its curricula and developing assessments for these new curricula is paramount. We have used the basis of many of these new changes (scientific practices, crosscutting concepts, and core ideas) to develop sets of criteria that can be used to guide assessment development for this new curriculum. We present a case study that uses the criteria we have developed to revise a traditional physics assessment item into an assessment item that is much more aligned with the goals of current transformation efforts. Assessment items developed using this criteria can be used to assess student learning of both the concepts and process of science.Comment: Revised version for PERC 2015 Conference Proceeding

Consuming transgenic goats' milk containing the antimicrobial protein lysozyme helps resolve diarrhea in young pigs.

Childhood diarrhea is a significant problem in many developing countries and E. coli is a main causative agent of diarrhea in young children. Lysozyme is an antimicrobial protein highly expressed in human milk, but not ruminant milk, and is thought to help protect breastfeeding children against diarrheal diseases. We hypothesized that consumption of milk from transgenic goats which produce human lysozyme (hLZ-milk) in their milk would accelerate recovery from bacterial-induced diarrhea. Young pigs were used as a model for children and infected with enterotoxigenic E. coli. Once clinical signs of diarrhea developed, pigs were fed hLZ-milk or non-transgenic control goat milk three times a day for two days. Clinical observations and complete blood counts (CBC) were performed. Animals were euthanized and samples collected to assess differences in histology, cytokine expression and bacterial translocation into the mesenteric lymph node. Pigs consuming hLZ-milk recovered from clinical signs of infection faster than pigs consuming control milk, with significantly improved fecal consistency (p = 0.0190) and activity level (p = 0.0350). The CBC analysis showed circulating monocytes (p = 0.0413), neutrophils (p = 0.0219), and lymphocytes (p = 0.0222) returned faster to pre-infection proportions in hLZ-milk fed pigs, while control-fed pigs had significantly higher hematocrit (p = 0.027), indicating continuing dehydration. In the ileum, pigs fed hLZ-milk had significantly lower expression of pro-inflammatory cytokine IL-8 (p = 0.0271), longer intestinal villi (p<0.0001), deeper crypts (p = 0.0053), and a thinner lamina propria (p = 0.0004). These data demonstrate that consumption of hLZ-milk helped pigs recover from infection faster, making hLZ-milk an effective treatment of E. coli-induced diarrhea

Symposium Introduction: Advancing Intellectual Property Goals Through Prevention and Alternative Dispute Resolution

This essay offers a brief background to the issues that prompted a global exploration of alternative methods for preventing and resolving IP disputes. Part One describes the exploding importance of IP rights and law and consequent challenges to court adjudication. Part Two offers a snapshot of current IP enforcement methods: traditional and emerging, public and private, domestic and international. Part Three suggests factors toward matching IP problems with alternative procedures for their effective resolution. Finally, woven throughout this essay is a recommendation of stronger involvement by public domestic or international bodies in dispute prevention and ADR methods

Structural Determinants of Adhesion by Protocadherin-19 and Implications for Its Role in Epilepsy

Non-clustered δ-protocadherins are homophilic cell adhesion molecules essential for the development of the vertebrate nervous system, as several are closely linked to neurodevelopmental disorders. Mutations in protocadherin-19 (PCDH19) result in a female-limited, infant-onset form of epilepsy (PCDH19-FE). Over 100 mutations in PCDH19 have been identified in patients with PCDH19-FE, about half of which are missense mutations in the adhesive extracellular domain. Neither the mechanism of homophilic adhesion by PCDH19, nor the biochemical effects of missense mutations are understood. Here we present a crystallographic structure of the minimal adhesive fragment of the zebrafish Pcdh19 extracellular domain. This structure reveals the adhesive interface for Pcdh19, which is broadly relevant to both non-clustered δ and clustered protocadherin subfamilies. In addition, we show that several PCDH19-FE missense mutations localize to the adhesive interface and abolish Pcdh19 adhesion in in vitro assays, thus revealing the biochemical basis of their pathogenic effects during brain development

White-tailed Deer Browse Preferences for South Texas and the Edwards Plateau

8 pp., 2 color photos, 4 tables, 2 graphsDeer prefer forbs, but these plants are not always available. Browse plants actually make up the major part of deer diets, and the specific browse plants deer eat depends on plant palatibility and availability. This publication explains deer nutrition and methods of evaluating the quality of deer diets. There are tables of preferred plants and their nutritional quality