75 research outputs found

    Physiographic Controls on Landfast Ice Variability from 20 Years of Maximum Extents across the Northwest Canadian Arctic

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    Landfast ice is a defining feature among Arctic coasts, providing a critical transport route for communities and exerting control over the exposure of Arctic coasts to marine erosion processes. Despite its significance, there remains a paucity of data on the spatial variability of landfast ice and limited understanding of the environmental processes’ controls since the beginning of the 21st century. We present a new high spatiotemporal record (2000–2019) across the Northwest Canadian Arctic, using MODIS Terra satellite imagery to determine maximum landfast ice extent (MLIE) at the start of each melt season. Average MLIE across the Northwest Canadian Arctic declined by 73% in a direct comparison between the first and last year of the study period, but this was highly variable across regional to community scales, ranging from 14% around North Banks Island to 81% in the Amundsen Gulf. The variability was largely a reflection of 5–8-year cycles between landfast ice rich and poor periods with no discernible trend in MLIE. Interannual variability over the 20-year record of MLIE extent was more constrained across open, relatively uniform, and shallower sloping coastlines such as West Banks Island, in contrast with a more varied pattern across the numerous bays, headlands, and straits enclosed within the deep Amundsen Gulf. Static physiographic controls (namely, topography and bathymetry) were found to influence MLIE change across regional sites, but no association was found with dynamic environmental controls (storm duration, mean air temperature, and freezing and thawing degree day occurrence). For example, despite an exponential increase in storm duration from 2014 to 2019 (from 30 h to 140 h or a 350% increase) across the Mackenzie Delta, MLIE extents remained relatively consistent. Mean air temperatures and freezing and thawing degree day occurrences (over 1, 3, and 12-month periods) also reflected progressive northwards warming influences over the last two decades, but none showed a statistically significant relationship with MLIE interannual variability. These results indicate inferences of landfast ice variations commonly taken from wider sea ice trends may misrepresent more complex and variable sensitivity to process controls. The influences of different physiographic coastal settings need to be considered at process level scales to adequately account for community impacts and decision making or coastal erosion exposure

    Exercise training to improve brain health in older people living with HIV: Study protocol for a randomized controlled trial

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    BACKGROUND: With the advent of antiretrovirals, people living with HIV are living near-normal lifespans. However, people living with HIV are at greater risk of experiencing cognitive impairment and reduced brain integrity despite well-controlled viremia. A robust literature supports exercise interventions as a method of improving cognition and structural brain integrity in older individuals without HIV. The effects of exercise on cardiometabolic, neurocognitive, and neural structures in middle-aged to older people living with HIV are less well known, with few prospective studies examining these measures. OBJECTIVE: This prospective randomized clinical trial will examine the effects of a 6-month exercise training intervention compared to a 6-month stretching intervention (control) on cardiorespiratory fitness, physical function and strength, cognition, and neuroimaging measures of brain volumes and cerebral blood flow in people living with HIV. METHODS: Sedentary middle-aged to older people living with HIV (ages≥40; n=150) with undetectable HIV viral load (\u3c20 copies/mL) will be enrolled in the study. At the baseline and final visit, fasting plasma lipid, insulin, glucose, and brain neurotrophic factor concentrations; cardiorespiratory fitness; cognitive performance; brain volumes; and cerebral blood flow via a magnetic resonance imaging scan will be measured. Participants will be randomized in a 2:1 ratio to either the exercise or control stretching intervention. All participants will complete their assigned programs at a community fitness center 3 times a week for 6 months. A professional fitness trainer will provide personal training guidance at all sessions for individuals enrolled in both arms. Individuals randomized to the exercise intervention will perform endurance and strength training exercises, while those randomized to the control intervention will perform stretches to increase flexibility. A midpoint visit (at 3 months) will assess cognitive performance, and at the end point visit, subjects will undergo cardiorespiratory fitness and cognition testing, and a magnetic resonance imaging scan. Physical activity throughout the duration of the trial will be recorded using an actigraph. RESULTS: Recruitment and data collection are complete as of December 2020. Data processing, cleaning, and organization are complete as of December 2021. Data analysis began in January 2022, with the publication of study results for primary aims 1 and 2 expected by early 2023. CONCLUSIONS: This study will investigate the effects of a 6-month aerobic and resistance exercise training intervention to improve cardiometabolic risk factors, cognitive performance, cerebral structure, and blood flow in sedentary people living with HIV. Results will inform clinicians and patients of the potential benefits of a structured aerobic exercise training program on the cognitive, functional, and cardiometabolic health status of older people living with HIV. Assessment of compliance will inform the development and implementation of future exercise programs for people living with HIV. TRIAL REGISTRATION: ClinicalTrials.gov NCT02663934; https://clinicaltrials.gov/ct2/show/NCT02663934. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/41421

    Defining Seropositivity Thresholds for Use in Trachoma Elimination Studies.

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    BACKGROUND: Efforts are underway to eliminate trachoma as a public health problem by 2020. Programmatic guidelines are based on clinical signs that correlate poorly with Chlamydia trachomatis (Ct) infection in post-treatment and low-endemicity settings. Age-specific seroprevalence of anti Ct Pgp3 antibodies has been proposed as an alternative indicator of the need for intervention. To standardise the use of these tools, it is necessary to develop an analytical approach that performs reproducibly both within and between studies. METHODOLOGY: Dried blood spots were collected in 2014 from children aged 1-9 years in Laos (n = 952) and Uganda (n = 2700) and from people aged 1-90 years in The Gambia (n = 1868). Anti-Pgp3 antibodies were detected by ELISA. A number of visual and statistical analytical approaches for defining serological status were compared. PRINCIPAL FINDINGS: Seroprevalence was estimated at 11.3% (Laos), 13.4% (Uganda) and 29.3% (The Gambia) by visual inspection of the inflection point. The expectation-maximisation algorithm estimated seroprevalence at 10.4% (Laos), 24.3% (Uganda) and 29.3% (The Gambia). Finite mixture model estimates were 15.6% (Laos), 17.1% (Uganda) and 26.2% (The Gambia). Receiver operating characteristic (ROC) curve analysis using a threshold calibrated against external reference specimens estimated the seroprevalence at 6.7% (Laos), 6.8% (Uganda) and 20.9% (The Gambia) when the threshold was set to optimise Youden's J index. The ROC curve analysis was found to estimate seroprevalence at lower levels than estimates based on thresholds established using internal reference data. Thresholds defined using internal reference threshold methods did not vary substantially between population samples. CONCLUSIONS: Internally calibrated approaches to threshold specification are reproducible and consistent and thus have advantages over methods that require external calibrators. We propose that future serological analyses in trachoma use a finite mixture model or expectation-maximisation algorithm as a means of setting the threshold for ELISA data. This will facilitate standardisation and harmonisation between studies and eliminate the need to establish and maintain a global calibration standard

    Ocean and coastal acidification off New England and Nova Scotia

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    Author Posting. © The Oceanography Society, 2015. This article is posted here by permission of The Oceanography Society for personal use, not for redistribution. The definitive version was published in Oceanography 28, no. 2 (2015): 182-197, doi:10.5670/oceanog.2015.41.New England coastal and adjacent Nova Scotia shelf waters have a reduced buffering capacity because of significant freshwater input, making the region’s waters potentially more vulnerable to coastal acidification. Nutrient loading and heavy precipitation events further acidify the region’s poorly buffered coastal waters. Despite the apparent vulnerability of these waters, and fisheries’ and mariculture’s significant dependence on calcifying species, the community lacks the ability to confidently predict how the region’s ecosystems will respond to continued ocean and coastal acidification. Here, we discuss ocean and coastal acidification processes specific to New England coastal and Nova Scotia shelf waters and review current understanding of the biological consequences most relevant to the region. We also identify key research and monitoring needs to be addressed and highlight existing capacities that should be leveraged to advance a regional understanding of ocean and coastal acidification.This project was supported in part by an appointment to the Internship/Research Participation Program at the Office of Water, US Environmental Protection Agency (EPA), administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and the EPA. JS acknowledges support from NASA grant from NNX14AL84G NASA-CCS

    World Congress Integrative Medicine & Health 2017: Part one

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    Community-scale changes to landfast ice along the coast of Alaska over 2000-2022

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    Landfast sea ice that forms along the Arctic coastline is of great importance to coastal Alaskan communities. It provides a stable platform for transportation and traditional activities, protects the coastline from erosion, and serves as a critical habitat for marine mammals. Here we present a full assessment of landfast ice conditions across a continuous 7885 km length of the Alaska coastline over 2000–2022 using satellite imagery. We find that the maximum landfast ice extent, usually occurring in March, averaged 67 002 km ^2 during our study period: equivalent to 4% of the state’s land area. The maximum extent of landfast ice, however, exhibits considerable interannual variability, from a minimum of 29 871 km ^2 in 2019 to a maximum of 87 571 km ^2 in 2010. Likewise, the landfast ice edge position averages 22.9 km from the coastline but, at the community-scale, can range from 2.8 km (in Gambell) to 71.1 km (in Deering). Landfast ice breakup date averages 2 June but also varies considerably both between communities (3 May in Quinhagak to 24 July in Nuiqsut) and interannually. We identify a strong control of air temperature on breakup timing and use this relationship to project future losses of ice associated with Paris Climate Agreement targets. Under 2 °C of global air temperature warming, we estimate the average Alaskan coastal community will lose 19 days of ice, with the northernmost communities projected to lose 50 days or more. Overall, our results emphasize the highly localized nature of landfast ice processes and the vulnerability of coastal Arctic communities in a warming climate
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