A Model of System Effectiveness and its Application to Educational Organizations

Working Paper Serie

Role of estrogen and progesterone receptors in neonatal uterine cell proliferation in the mouse

The major endocrine regulators of the female reproductive tract are 17β-estradiol (E2) and progesterone (P4). This review discusses our recent work related to the roles of E2 and P4 and their receptors, estrogen receptor 1 (ESR1) and progesterone receptor (PR), respectively, in the neonatal uterus. Neonatal uterine cells in mice are mitogenically responsive to estrogens, but neonatal ovariectomy does not inhibit pre-weaning uterine cell proliferation, indicating that this process does not require endogenous estrogens. Neonatal uterine cell proliferation could result from ligand-independent growth factor activation of ESR1, or be independent of ESR1 neonatally despite its obligatory role in adult uterine epithelial proliferation. To determine the role of ESR1 in uterine development, we analyzed cell proliferation and uterine gland development (adenogenesis) in wild-type (WT) and Esr1 knockout (Esr1KO) mice postnatally. Our results indicate that pre-weaning uterine cell proliferation and adenogenesis are independent of ESR1, but these processes become dependent on E2/ESR1 signaling for maintenance and further proliferation and uterine growth during puberty. How pre- weaning uterine cell proliferation and adenogenesis occur independently of E2/ESR1 signaling remains unknown, but ligand-independent activation of ESR1 is not involved in this process. The synthetic glucocorticoid dexamethasone (Dex) inhibits luminal epithelial (LE) proliferation in neonatal mouse uteri, but it has been unclear whether Dex effects were mediated by glucocorticoid receptor (GR) and/or PR. We have used PR knockout (PRKO) mice to test whether PR is required for Dex inhibition of LE proliferation. Our results indicate that maximal inhibitory Dex effects on uterine LE proliferation require PR, possibly reflecting Dex crosstalk with PR. Inhibitory effects of Dex and P4 on LE proliferation may also involve GR binding, as indicated by the small but significant inhibition of LE proliferation by both Dex and P4 in PRKO mice

The use of alternative energy technologies in buildings : the influence of engineering consultants

The UK Government has set the target of reducing CO2 emissions by 60% by 2050. Energy used by buildings is presently responsible for around half of C02 emissions in the UK. There are many established methods for reducing such emissions from building operation but these opportunities are not being seized to their full potential. One of these methods is the use of Alternative Energy Technologies (AETs) integrated into the built environment. Engineering consultants have a key role in the design of buildings, their energy consumption and the consideration of AETs. The objectives of this thesis are to explore the process of delivery of AETs in building projects, the key factors that influence the viability of these technologies and the capability of engineering consultants to increase their rate of uptake. While there are many published lists of incentives and restrictions to using these technologies, there are few reports of their impact in practical contexts. Project involvement provided evidence of significant variations in the drivers and barriers to using AETs, the design team perceptions and the approaches used for assessments. These insights were investigated in detail through participative research techniques. Initial focus groups led to the development of a structured interview programme administered in 2 phases. The first phase of interviews investigated the experiences of 41 participants representing a range of building project stakeholders. The second phase of interviews looks more closely at 24 relevant projects from the perspective of the engineering consultant, investigating the decision-making approaches used and the influence of factors throughout the design process in more detail. As a result a hierarchy of the importance of specific drivers and barriers to using AETs in building projects was established. It was found that there is a large amount of variation in their importance between projects. Despite this variation the emphasis for assessment methods is on financial terms, largely ignoring more qualitative concerns. This lack of suitable assessment methodologies along with a lack of education, motivation and case study information in the building industry are restricting the use of AETs in UK building projects. It is proposed that to address this, engineering consultants need to be better informed and need to develop and embrace more holistic technology assessment methods that account for qualitative and quantitative considerations.EThOS - Electronic Theses Online ServiceEPSRCGBUnited Kingdo

Panel Discussion On The Management Of Allergies In Geriatric Patients†

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111236/1/jgs00790.pd

The 2012 Lyrids from Non-traditional Observing Platforms

The NASA Meteoroid Environment Office (MEO) observed meteors during the Lyrid meteor shower peak on 22 April 2012 from three different observing platforms: the ground, a helium-filled balloon, and from the International Space Station (ISS). Even though the Lyrids are not noted for spectacular rates, the combination of New Moon and a favorable viewing geometry from ISS presented a unique opportunity to simultaneously image shower meteors from above the atmosphere and below it. In the end, however, no meteors were observed simultaneously, and it was impossible to identify Lyrids with 100% confidence among the 155 meteors observed from ISS and the 31 observed from the balloon. Still, this exercise proved successful in that meteors could be observed from a simple and inexpensive balloon-based payload and from less-than-optimal cameras on ISS

Lunar Meteoroid Impact Observations and the Flux of Kilogram-sized Meteoroids

Lunar impact monitoring provides useful information about the flux of meteoroids in the tens of grams to kilograms size range. The large collecting area of the night side of the lunar disk, approximately 3.4x10(exp 6) sq km in our camera field-of-view, provides statistically significant counts of the meteoroids. Nearly 200 lunar impacts have been observed by our program in roughly 3.5 years. Photometric calibration of the flashes along with the luminous efficiency (determined using meteor showers1,2,3) and assumed velocities provide their sizes. The asymmetry in the flux on the evening and morning hemispheres of the Moon is compared with sporadic and shower sources to determine their most likely origin. The asymmetry between the two hemispheres seen in Figure 1 is due to the impact rate and not to observational bias. Comparison with other measurements of the large meteoroid fluxes is consistent with these measurements as shown in Figure 2. The flux of meteoroids in this size range has important implications for the near-Earth object population and for impact risk for lunar spacecraf

Core-collapse Supernovae from the Palomar Transient Factory: Indications for a Different Population in Dwarf Galaxies

We use the first compilation of 72 core-collapse supernovae (SNe) from the Palomar Transient Factory (PTF) to study their observed subtype distribution in dwarf galaxies compared to giant galaxies. Our sample is the largest single-survey, untargeted, spectroscopically classified, homogeneous collection of core-collapse events ever assembled, spanning a wide host-galaxy luminosity range (down to M_r ≈ –14 mag) and including a substantial fraction (>20%) of dwarf (M_r ≥ –18 mag) hosts. We find more core-collapse SNe in dwarf galaxies than expected and several interesting trends emerge. We use detailed subclassifications of stripped-envelope core-collapse SNe and find that all Type I core-collapse events occurring in dwarf galaxies are either SNe Ib or broad-lined SNe Ic (SNe Ic-BL), while "normal" SNe Ic dominate in giant galaxies. We also see a significant excess of SNe IIb in dwarf hosts. We hypothesize that in lower metallicity hosts, metallicity-driven mass loss is reduced, allowing massive stars that would have appeared as "normal" SNe Ic in metal-rich galaxies to retain some He and H, exploding as Ib/IIb events. At the same time, another mechanism allows some stars to undergo extensive stripping and explode as SNe Ic-BL (and presumably also as long-duration gamma-ray bursts). Our results are still limited by small-number statistics, and our measurements of the observed N(Ib/c)/N(II) number ratio in dwarf and giant hosts (0.25^(+0.3)_(–0.15) and 0.23^(+0.11)_(–0.08), respectively; 1σ uncertainties) are consistent with previous studies and theoretical predictions. As additional PTF data accumulate, more robust statistical analyses will be possible, allowing the evolution of massive stars to be probed via the dwarf-galaxy SN population

NASA's Lunar Impact Monitoring Program

NASA's Meteoroid Environment Office nas implemented a program to monitor the Moon for meteoroid impacts from the Marshall Space Flight Center. Using off-the-shelf telescopes and video equipment, the moon is monitored for as many as 10 nights per month, depending on weather. Custom software automatically detects flashes which are confirmed by a second telescope, photometrically calibrated using background stars, and published on a website for correlation with other observations, Hypervelocity impact tests at the Ames Vertical Gun Facility have been performed to determine the luminous efficiency ana ejecta characteristics. The purpose of this research is to define the impact ejecta environment for use by lunar spacecraft designers of the Constellation (manned lunar) Program. The observational techniques and preliminary results will be discussed

The economic and innovation contribution of universities: a regional perspective

Universities and other higher education institutions (HEIs) have come to be regarded as key sources of knowledge utilisable in the pursuit of economic growth. Although there have been numerous studies assessing the economic and innovation impact of HEIs, there has been little systematic analysis of differences in the relative contribution of HEIs across regions. This paper provides an exploration of some of these differences in the context of the UK’s regions. Significant differences are found in the wealth generated by universities according to regional location and type of institution. Universities in more competitive regions are generally more productive than those located in less competitive regions. Also, traditional universities are generally more productive than their newer counterparts, with university productivity positively related to knowledge commercialisation capabilities. Weaker regions tend to be more dependent on their universities for income and innovation, but often these universities under-perform in comparison to counterpart institutions in more competitive regions. It is argued that uncompetitive regions lack the additional knowledge infrastructure, besides universities, that are more commonly a feature of more competitive regions

Impact of protein-ligand solvation and desolvation on transition state thermodynamic properties of adenosine A2Aligand binding kinetics

Ligand-protein binding kinetic rates are growing in importance as parameters to consider in drug discovery and lead optimization. In this study we analysed using surface plasmon resonance (SPR) the transition state (TS) properties of a set of six adenosine A2Areceptor inhibitors, belonging to both the xanthine and the triazolo-triazine scaffolds. SPR highlighted interesting differences among the ligands in the enthalpic and entropic components of the TS energy barriers for the binding and unbinding events. To better understand at a molecular level these differences, we developed suMetaD, a novel molecular dynamics (MD)-based approach combining supervised MD and metadynamics. This method allows simulation of the ligand unbinding and binding events. It also provides the system conformation corresponding to the highest energy barrier the ligand is required to overcome to reach the final state. For the six ligands evaluated in this study their TS thermodynamic properties were linked in particular to the role of water molecules in solvating/desolvating the pocket and the small molecules. suMetaD identified kinetic bottleneck conformations near the bound state position or in the vestibule area. In the first case the barrier is mainly enthalpic, requiring the breaking of strong interactions with the protein. In the vestibule TS location the kinetic bottleneck is instead mainly of entropic nature, linked to the solvent behaviour