The relationship between psychopathy traits and neurodevelopmental disorders in forensic populations : a systematic PRISMA review

Background: Numerous studies investigate the rate of neurodevelopmental disorders in forensic populations. Studies have also investigated the rate of psychopathy in such settings. However, there appears to be a paucity of studies looking at both of these (co-morbidity between these disorders) and the possible relationships between the two in forensic populations. Method: Presented here are the findings from a systematic review conducted, following PRISMA guidelines, of the peer-reviewed literature. The review identified studies that investigated the rate and/or relationship of neurodevelopmental disorders (Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorders) and psychopathy in a forensic sample population without relying on previous childhood diagnosis of neurodevelopmental disorders. Results: Twenty-two studies were identified which investigated the rate and/or relationship of neurodevelopmental disorders and psychopathy in a forensic sample population without relying on previous childhood diagnosis of neurodevelopmental disorders such as attention-deficit/hyperactivity disorder and autism spectrum disorders. Conclusion: The findings highlight the need for the development of screening and diagnostic tools especially targeted at offenders and validated for this purpose

An Improved Method for the Large-Scale Processing of Woad (Isatis tinctoria) for Possible Commercial Production of Woad Indigo

The increasing use of alternative crops has meant the introduction of new technologies to process their products. In this work, an alternative method is presented for the extraction of natural indigo from woad (Isatis tinctoria) based on a technique used to extract indigo from Indigofera spp. This method does not rely on the old fermentation procedure used throughout Northern Europe and is cheap, clean and efficient. Evolved from laboratory-based tests, it involves steeping the leaves at low pH in warm water and extracting the indigo at a higher pH, followed by ultra-filtration of the product, which is then left to air-dry. Problems encountered during the development of the technique and how they were overcome are discussed. © 1998 Silsoe Research Institute

Draft genome sequences of seven isolates of Phytophthora ramorum EU2 from Northern Ireland.

Published onlineHere we present draft-quality genome sequence assemblies for the oomycete Phytophthora ramorum genetic lineage EU2. We sequenced genomes of seven isolates collected in Northern Ireland between 2010 and 2012. Multiple genome sequences from P. ramorum EU2 will be valuable for identifying genetic variation within the clonal lineage that can be useful for tracking its spread.Work in the laboratory of DJS is supported by the BBSRC (BB/ L012499/1 and Nornex). Sequencing was performed by the Exeter Sequencing Service at the University of Exeter, which is supported by Wellcome Trust Institutional Strategic Support Fund (WT097835MF), Wellcome Trust Multi-User Equipment Award (WT101650MA) and BBSRC LOLA award (BB/K003240/1). LdlMS was supported by COFORD (Council for Forest Research and Development) Ireland, Project reference: 10/721

Excited-State Positronium Formation from Helium, Argon, and Xenon

The cross sections for the formation of positronium in the 2P state in collisions of positrons with He, Ar, and Xe atoms have been determined by measuring coincidences between the remnant ion and the Lyman-alpha photon from positronium. The maximum fractional contributions of these to the total Ps formation cross sections increase from approximately 0.06 +/- 0.01 in He to 0.12 +/- 0.04 in Ar and 0.26 +/- 0.09 in Xe. In the case of He, good agreement is found with a coupled-state calculation; for Ar and Xe, measurements are compared with a distorted-wave Born approximation

Ionization cross-sections for positron collisions with N2

The total and direct ionization cross-sections for positron impact on molecular nitrogen have been measured in the energy range from 5 eV to 850 eV. The results are compared with other experimental and theoretical determinations

Simultaneous Ionization and Excitation of Molecules by Positron Impact

Cross sections for ionization excitation of molecules by positron impact have been measured for the first time by scattering a positron beam from CO2 and N-2. The cross sections have been observed to exceed those for electron impact by up to a factor of similar to 3 for CO2 and similar to 5 for N-2. The enhancement arises primarily via positronium formation. The cross sections account for up to similar to 12% and 20% of the total cross sections for positron scattering from N-2 and CO2, respectively

Early impact of rotavirus vaccination in a large paediatric hospital in the UK.

The impact of routine rotavirus vaccination on community-acquired (CA) and healthcare-associated (HA) rotavirus gastroenteritis (RVGE) at a large paediatric hospital, UK, was investigated over a 13-year period. A total of 1644 hospitalized children aged 0-15 years tested positive for rotavirus between July 2002 and June 2015. Interrupted time-series analysis demonstrated that, post vaccine introduction (July 2013 to June 2015), CA- and HA-RVGE hospitalizations were 83% [95% confidence interval (CI): 72-90%) and 83% (95% CI: 66-92%] lower than expected, respectively. Rotavirus vaccination has rapidly reduced the hospital rotavirus disease burden among both CA- and HA-RVGE cases

Differences in antigen-specific CD4+ responses to opportunistic infections in HIV infection

HIV-infected individuals with severe immunodeficiency are at risk of opportunistic infection (OI). Tuberculosis (TB) may occur without substantial immune suppression suggesting an early and sustained adverse impact of HIV on Mycobacterium tuberculosis (MTB)-specific cell mediated immunity (CMI). This prospective observational cohort study aimed to observe differences in OI-specific and MTB-specific CMI that might underlie this. Using polychromatic flow cytometry, we compared CD4+ responses to MTB, cytomegalovirus (CMV), Epstein-Barr virus (EBV) and Candida albicans in individuals with and without HIV infection. MTB-specific CD4+ T-cells were more polyfunctional than virus specific (CMV/EBV) CD4+ T-cells which predominantly secreted IFN-gamma (IFN-γ) only. There was a reduced frequency of IFN-γ and IL-2 (IL-2)-dual-MTB-specific cells in HIV-infected individuals, which was not apparent for the other pathogens. MTB-specific cells were less differentiated especially compared with CMV-specific cells. CD127 expression was relatively less frequent on MTB-specific cells in HIV co-infection. MTB-specific CD4+ T-cells PD-1 expression was infrequent in contrast to EBV-specific CD4+ T-cells. The variation in the inherent quality of these CD4+ T-cell responses and impact of HIV co-infection may contribute to the timing of co-infectious diseases in HIV infection

Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using recombinant DNA libraries

A method of in situ hybridization for visualizing individual human chromosomes from pter to qter, both in metaphase spreads and interphase nuclei, is reported. DNA inserts from a single chromosomal library are labeled with biotin and partially preannealed with a titrated amount of total human genomic DNA prior to hybridization with cellular or chromosomal preparations. The cross-hybridization of repetitive sequences to nontargeted chromosomes can be markedly suppressed under appropriate preannealing conditions. The remaining single-stranded DNA is hybridized to specimens of interest and detected with fluorescent or enzymelabeled avidin conjugates following post-hybridization washes. DNA inserts from recombinant libraries for chromosomes 1, 4, 7, 8, 13, 14, 18, 20, 21, 22, and X were assessed for their ability to decorate specifically their cognate chromosome; most libraries proved to be highly specific. Quantitative densitometric analyses indicated that the ratio of specific to nonspecific hybridization signal under optimal preannealing conditions was at least 8:1. Interphase nuclei showed a cohesive territorial organization of chromosomal domains, and laserscanning confocal fluorescence microscopy was used to aid the 3-D visualization of these domains. This method should be useful for both karyotypic studies and for the analysis of chromosome topography in interphase cells