Letter, 1976 March 29, from J. Lawrence, Cook to Eva Jessye

1 page, Cook was an old friend of Jessye

Letter, 1974 May 20, from J. Lawrence Cook to Eva Jessye

1 page, Cook was a friend of Jessye

Letter, 1973 April 1, from J. Lawrence Cook to Eva Jessye

1 page, Cook sent Jessye material for her archives

Parallel Knowledge Discovery from Large Complex Databases

NASA is focusing on grand challenge problems in Earth and space sciences. Within these areas of science, new instrumentation will be providing scientists with unprecedented amounts of unprocessed data. Our goal is to design and implement a system that takes raw data as input and efficiently discovers interesting concepts that can target areas for further investigation and can be used to compress the data. Our approach will provide an intelligent parallel data analysis system

Improving quality of life for people with dementia in care homes: Making psychosocial interventions work

This is the author accepted manuscript. The final version is available from Cambridge University Press via the DOI in this recordPsychosocial interventions can improve behaviour and mood in people with dementia, but it is unclear how to maximise their effectiveness or acceptability in residential settings. Aims To understand what underlies the successful implementation of psychosocial interventions in care homes. Method Systematic review and meta-synthesis of qualitative research. Results The synthesis of 39 qualitative papers revealed that beneficial psychosocial interventions met the needs of people with dementia to connect with others, make a meaningful contribution and reminisce. Successful implementation rested on the active engagement of staff and family and the continuing provision of tailored interventions and support. This necessitated staff time, and raised issues around priorities and risk, but ultimately helped redefine staff attitudes towards residents and the caregiving role. Conclusions The findings from the meta-synthesis can help to inform the development and evaluation of psychosocial interventions in care homes and support their widespread implementation in clinical settings.National Institute for Health Research (NIHR

\u3ci\u3e β3-adrenergic agonists mimic eustress response and reduce leptin-mediated proliferation in a GBM cell line \u3c/i\u3e

A great deal of mental stress, depression, and anxiety often overwhelm cancer patients; those diagnosed with glioblastoma multiforme (GBM) are no exception. Different types of stress invariably impact what has been termed “the brain-adipocyte BDNF/leptin axis” (Dr. Cao and colleagues of the Comprehensive Cancer Center at The Ohio State University). For example, eustress (good stress) and distress (bad stress) both lead to increased sympathetic activity and adrenal gland stimulation, yet eustress reduces leptin levels and attenuates tumor growth while distress increases leptin levels and augments tumor growth. Complicating matters in GBM is that leptin and its receptor are expressed at much higher levels than in normal glial cells and provides a potential autocrine signaling pathway. In this study, we confirm that 200 ng/mL of leptin-conditioned media increases cell proliferation of the established GBM cell line T98G. We hypothesized that elevated sympathoadrenal activity would increase cell proliferation and be additive to leptin\u27s effects. To the contrary, adding 300 pg/mL of epinephrine to leptin-conditioned media blocked leptin-mediated proliferation. Because beta3-adrenergic receptor stimulation suppresses leptin gene expression and release in adipocytes, we hypothesized that a beta3-adrenergic agonist would counteract leptin\u27s effects on T98G cell proliferation. Use of the beta3-adrenergic agonist BRL 37344 did not only counteract leptin\u27s effects but also significantly reduced T98G cell proliferation in unconditioned media. This has immediate translational value in that treating GBM with a beta3-adrenergic agonist may reduce tumor proliferation through receptor activation and by blocking the leptin-leptin receptor autocrine loop. Moreover, recent reports indicate that beta3-adrenergic agonists capable of crossing the blood-brain barrier (like SR 58611A) may be beneficial for anxiety and depression, further improving the quality of life for brain tumor patients

\u3ci\u3e Leptin Promotes Glioblastoma \u3c/i\u3e

The hormone leptin has a variety of functions. Originally known for its role in satiety and weight loss, leptin more recently has been shown to augment tumor growth in a variety of cancers. Within gliomas, there is a correlation between tumor grade and tumor expression of leptin and its receptor. This suggests that autocrine signaling within the tumor microenvironment may promote the growth of high-grade gliomas. Leptin does this through stimulation of cellular pathways that are also advantageous for tumor growth and recurrence: antiapoptosis, proliferation, angiogenesis, and migration. Conversely, a loss of leptin expression attenuates tumor growth. In animal models of colon cancer and melanoma, a decline in the expression and secretion of leptin resulted in a reduction of tumor growth. In these models, positive mental stimulation through environmental enrichment decreased leptin secretion and improved tumor outcome. This review explores the link between leptin and glioblastom

Is Higgs inflation ruled out?

We consider the status of Higgs inflation in light of the recently announced detection of B modes in the polarization of the cosmic microwave background radiation by the BICEP2 Collaboration. In order for the primordial B-mode signal to be observable by BICEP2, the energy scale of inflation must be high: Vinf≈2×1016-GeV. Higgs inflation generally predicts a small amplitude of tensor perturbations, and therefore it is natural to ask if Higgs inflation might accommodate this new measurement. We find that the answer is essentially no, unless one considers either extreme fine-tuning or possibly adding new beyond the Standard Model fields, which remove some of the more attractive features of the original idea. We also explore the possible importance of a factor that has not previously been explicitly incorporated, namely the gauge dependence of the effective potential used in calculating inflationary observables (e.g., nS and r), to see if this might provide additional wiggle room. Such gauge effects are comparable to the effects of Higgs mass uncertainties and other observables already considered in the analysis, and therefore they are relevant for constraining models. However, they are therefore too small to remove the apparent incompatibility between the BICEP2 observation and the predictions of Higgs inflation