Electronics, music and computers

technical reportElectronic and computer technology has had and will continue to have a marked effect in the field of music. Through the years scientists, engineers, and musicians have applied available technology to new musical instruments, innovative musical sound production, sound analysis, and musicology. At the University of Utah we have designed and are implementing a communication network involving and electronic organ and a small computer to provide a tool to be used in music performance, the learning of music theory, the investigation of music notation, the composition of music, the perception of music, and the printing of music

Benzylammonium 2,4-bis(dicyanomethylene)-2,3-dihydroisoindolide

The cation and anion of the title salt, C⁷H₁₀N⁺.C₁₄H₄N₅-, are both bisected by a crystallographic mirror plane. Extensive hydrogen bonding, with the R₆⁶(28) graph-set motif, connects the ions into layers

Combining social network analysis and sentiment analysis to explore the potential for online radicalisation

The increased online presence of jihadists has raised the possibility of individuals being radicalised via the Internet. To date, the study of violent radicalisation has focused on dedicated jihadist websites and forums. This may not be the ideal starting point for such research, as participants in these venues may be described as “already madeup minds”. Crawling a global social networking platform, such as YouTube, on the other hand, has the potential to unearth content and interaction aimed at radicalisation of those with little or no apparent prior interest in violent jihadism. This research explores whether such an approach is indeed fruitful. We collected a large dataset from a group within YouTube that we identified as potentially having a radicalising agenda. We analysed this data using social network analysis and sentiment analysis tools, examining the topics discussed and what the sentiment polarity (positive or negative) is towards these topics. In particular, we focus on gender differences in this group of users, suggesting most extreme and less tolerant views among female users

Nasal Drug Delivery Systems: An Overview

Since ancient times, drugs have been administered via the nasal route for therapeutic and recreational purposes. The interest in, and importance, of the systemic effects of drugs administered through the nasal route, have expanded over recent decades. Intra-nasal administration of drugs offers an interesting alternative for achieving systemic therapeutic effects of drugs that are comparable to the parenteral route, which can be inconvenient at times or oral administration, which can result in unacceptably low drug bioavailability. So, it is important to understand the potential and limitations of various nasal drug delivery systems. Therefore, the aim of this review article is to discuss the various pharmaceutical dosage forms that have the potential to be utilised for local or systemic drug administration. It is intuitively expected that this review will help to understand and further to develop suitable intra-nasal formulations to achieve specific therapeutic objectives

Assessing the Attitudes and Perceptions of the Old Order Amish toward Genetic Testing for Familial Defective Apolipoprotein B-100

Through a founder effect, one in eight Lancaster County, PA, Amish harbors the pathogenic APOB variant R3527Q, causing Familial Defective Apolipoprotein B-100 (FDB) that is rare in the general population. Affected individuals are at increased risk for high low density lipoprotein (LDL) cholesterol levels and cardiovascular disease and may benefit from early screening and treatment. A qualitative interview approach was used to investigate the genetic risk perceptions of the Amish and their attitudes towards genetic testing for FDB. The goal was to identify elements necessary for a successful program that would identify high risk individuals in the Lancaster County Amish community and provide them with potentially lifesaving education and interventions. Thirty interviews were conducted. Collected data were analyzed and coded for common themes. Participants perceived a great deal of importance in genetic risk and were aware of the significant impact genetics have on health. Most individuals perceived genetic risk as more significant than family history. Twenty-four of 30 individuals would consider testing; of these, all 24 reported they would take proactive measures to reduce risks if given a positive result. Most would prefer diet modification and natural health remedies, with prescription medication only as a last resort. Several participants stated that most Amish people would be unlikely to test if they were feeling healthy. Cost was the most significant barrier to pursuing testing. Implementing a successful screening program would require community outreach and awareness, risk reduction education and support, and minimal out-of-pocket expenses. The program’s success provides insights into the efficacy of predictive genetic screening for the general population. [Abstract by authors.