Hardware Commissioning of the Refurbished ALPI Linac at INFN-LNL to Serve as SPES Exotic Beam Accelerator

Abstract The ALPI linac at INFN-LNL was substantially refurbished in 2018, especially in view of its use as secondary accelerator for exotic species in the framework of the SPES project. In particular: 10 magnetic triplets were replaced with higher gradient ones; two cryomodules with quarter wave resonator were moved from the PIAVE injector to ALPI, so as to make them available both for exotic and stable beams; the cryogenic plant was renovated; the whole linac, its injector and its beam lines were eventually realigned via LASER tracking (LT). The expected outcome of the refurbishment project is a larger beam transmission (crucial for the efficient transport of the unavoidably low current exotic beams) and improved overall reliability so as to further extend the lifetime of an already 25 years old machine. The hardware commissioning of this new configuration will be reported

Physiological and biochemical responses of <i>Quercus pubescens</i> to air warming and drought on acidic and calcareous soils

The drought- and thermo-tolerant Quercus pubescens, a tree species growing on both acidic and calcareous soils in the sub-Mediterranean region, was exposed to soil drought (-60% to -80% soil water content) and air warming (+1.2 C daytime temperature), singly and in combination. The experiment was conducted on two natural forest soils with similar texture but different pH (acidic and calcareous soils). The physiological (photosynthesis) and biochemical (antioxidant system) responses of Q. pubescens were investigated. On acidic soil, Q. pubescens had a higher reactive oxygen species (ROS) content than on calcareous soil, confirming that this species is better adapted to the latter soil type. A down-regulation of ascorbate-glutathione cycle enzymes suggests that ROS were used as signalling molecules. Air warming stimulated stomatal opening, while soil drought induced stomatal closure in the late afternoon and reduced Rubisco carboxylation efficiency. Photosynthetic performance in the combined treatment was higher than under single drought stress and similar to control and air warming. Q. pubescens biochemical responses depended on soil pH. On acidic soil, Q. pubescens trees exposed to air warming used ROS as signalling molecules. On calcareous soil, these trees were able to balance both soil drought and air warming stress, avoiding ROS toxic effects by increasing antioxidant enzyme activitiy and maintaining a high enzymatic antioxidant defence. When combined, drought and air warming induced either more severe (higher oxidative pressure and impairment of the light-harvesting complex) or different responses (decline of the thermal energy dissipation capacity) relative to the single stressors. Overall, however, Q. pubescens preserved the functionality of the photosynthetic apparatus and controlled the antioxidant system response, thus confirming its drought and thermo-tolerance and therefore its potential to adapt to the ongoing climate change

Mutable Collagenous Tissue Isolated from Echinoderms Leads to the Production of a Dermal Template That Is Biocompatible and Effective for Wound Healing in Rats

The mutable collagenous tissue (MCT) of echinoderms possesses biological peculiarities that facilitate native collagen extraction and employment for biomedical applications such as regenerative purposes for the treatment of skin wounds. Strategies for skin regeneration have been developed and dermal substitutes have been used to cover the lesion to facilitate cell proliferation, although very little is known about the application of novel matrix obtained from marine collagen. From food waste we isolated eco-friendly collagen, naturally enriched with glycosaminoglycans, to produce an innovative marine-derived biomaterial assembled as a novel bi-layered skin substitute (Marine Collagen Dermal Template or MCDT). The present work carried out a preliminary experimental in vivo comparative analysis between the MCDT and Integra, one of the most widely used dermal templates for wound management, in a rat model of full-thickness skin wounds. Clinical, histological, and molecular evaluations showed that the MCDT might be a valuable tool in promoting and supporting skin wound healing: it is biocompatible, as no adverse reactions were observed, along with stimulating angiogenesis and the deposition of mature collagen. Therefore, the two dermal templates used in this study displayed similar biocompatibility and outcome with focus on full-thickness skin wounds, although a peculiar cellular behavior involving the angiogenesis process was observed for the MCDT

Hardware Commissioning of the Renovated PIAVE Injector at INFN-LNL

Abstract During 2018, the PIAVE superconducting linac injector at INFN-LNL, based on superconducting RFQs and two cryomodules with quarter wave resonators, underwent a renovation plan. This operation was strictly related to the one carried out on ALPI [1], which will become a post-accelerator for both stable and exotic beams in a near future. PIAVE Quarter Wave Resonator (QWR) cryomodules, in operation since 2006, were moved to ALPI to be used for the acceleration of both stable beams and future exotic beams delivered from the cyclotron target-ion-source station, after appropriate purification, charge breeding and pre-acceleration stages. In order to cope with the removal of the two QWR cryomodules in PIAVE, a newly designed 80 MHz room temperature buncher was designed, built and tested: the buncher is required so as to match the longitudinal phase space between PIAVE superconducting RFQs (SRFQ1 and SRFQ2) and ALPI. In the same period, substantial refurbishments on the ECR ion source platform were carried out, in particular on its infrastructure and safety equipment. A problem on an electronic component on SRFQ2, though quickly fixed, delayed beam commissioning of the PIAVE injector, which will start at the end of May 2019